Introduction Features Methods and Definitions Precision Classification Comparision with experimental data Comparision with other computational methods Topology definitions Acknowledgements

Introduction

There are several thousands of PDB entries with structures of transmembrane, integral monotopic and peripheral peptides and proteins. However, the exact orientations of these peptides and proteins in biological membranes is unknown. A computational approach for optimizing the spatial arrangement of protein structures in lipid bilayers has been developed and applied here to all unique transmembrane and about 400 peripheral proteins from the PDB.

We hope that OPM will be helpful for planning future experimental and computational studies of membrane proteins and for interpreting their structural, functional and evolutionary features.

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