There are several thousand PDB entries with structures of transmembrane, integral monotopic and peripheral peptides and proteins. However, the exact orientations of these peptides and proteins in biological membranes is unknown. A computational approach for optimizing the spatial arrangement of protein structures in lipid bilayers has been developed and applied here to all unique structures of transmembrane proteins and a significant number of peripheral proteins from the PDB.
We hope that OPM will be helpful for planning future experimental and computational studies of membrane proteins and for interpreting their structural, functional and evolutionary features.
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