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• LIPID COMPOSITION ATLAS

• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

• Protein Links

• PDB Sum,
• PDB,
• OCA,
• MPKS,
• PDBTM,
• MPDB,
• CGDB

Membrane Protein Lipid Composition Atlas

1.		Archaebacterial membrane (54 proteins)
2.		Bacterial Gram-negative inner membrane (269 proteins)
3.		Bacterial Gram-negative outer membrane (136 proteins)
4.		Bacterial Gram-positive outer membrane (7 proteins)
5.		Bacterial Gram-positive plasma membrane (81 proteins)
6.		Chloroplast inner membrane (1 protein)
7.		Chloroplast outer membrane (0 proteins)
8.		Cytoplasmic granule membrane (1 protein)
9.		Endoplasmic reticulum membrane (125 proteins)
10.		Endosome membrane (35 proteins)
11.		Eukaryotic plasma membrane (479 proteins)
12.		Golgi membrane (22 proteins)
13.		Lysosome membrane (17 proteins)
14.		Mitochondrial inner membrane (51 proteins)
15.		Mitochondrial outer membrane (20 proteins)
16.		Nuclear inner membrane (3 proteins)
17.		Nuclear outer membrane (5 proteins)
18.		Peroxisome membrane (10 proteins)
19.		Secreted (681 proteins)
20.		Thylakoid membrane (31 proteins)
21.		Undefined (75 proteins)
22.		Vacuole membrane (16 proteins)
23.		Vesicle membrane (13 proteins)
24.		Viral membrane (40 proteins)

Lipid Composition in Bacterial gram-negative outer membrane

Bacterial gram-negative outer membrane

	1qjp » Outer membrane protein A (OMPA), disordered loops 25.4 ± 1.5 Å		1qj8 » Outer membrane protein X (OMPX) 23.6 ± 2.8 Å
	1p4t » Outer membrane protein NspA 24.9 ± 2.4 Å		2x55 » Plasminogen activator PLA (coagulase/fibrinolysin) 25.6 ± 1.9 Å
	1k24 » Outer membrane adhesin/invasin OpcA 25.4 ± 1.3 Å		1uyn » Autotransporter NalP 25.3 ± 1.3 Å
	1qd6 » Outer membrane phospholipase A 23.9 ± 1.0 Å		1tly » Bacterial Nucleoside Transporter Ts 23.4 ± 1.5 Å
	1t16 » Fatty Acid Transporter FadL 25.4 ± 1.3 Å		3pox » Porin OmpF 24.0 ± 0.8 Å
	1osm » Porin 24.0 ± 1.1 Å		2fgq » Anion-selective porin 25.0 ± 0.9 Å
	2por » Porin 23.4 ± 0.6 Å		3prn » Porin 23.2 ± 0.5 Å
	1af6 » Maltoporin 25.1 ± 0.7 Å		2mpr » Maltoporin 24.5 ± 1.0 Å
	1a0s » Sucrose-specific porin 23.8 ± 1.1 Å		1qfg » Ferric hydroxamate uptake receptor FhuA 24.7 ± 1.0 Å
	1fep » Ferric enterobactin receptor FepA 24.3 ± 1.1 Å		1kmo » Outer membrane transporter FecA 24.5 ± 1.2 Å
	1nqe » Outer membrane cobalamin transporter BtuB 23.4 ± 1.0 Å		2iah » Pyoverdine Outer Membrane Receptor FpvA 24.0 ± 0.5 Å
	1ek9 » Outer membrane protein TolC 24.6 ± 1.4 Å		1yc9 » Multidrug Resistance (VceC) protein 24.6 ± 1.0 Å
	1wp1 » Drug-Discharge Outer Membrane Protein, OprM 24.7 ± 1.2 Å		2vqi » P pilus usher PapC translocation domain 23.1 ± 1.0 Å
	1qwd » Outer membrane lipoprotein Blc 3.2 ± 2.0 Å		1i78 » Outer membrane protease OmpT 26.5 ± 1.6 Å
	1xkw » Fe(III)-pyochelin receptor FptA 24.8 ± 1.0 Å		1pho » Phosphoporin (PhoE) 24.1 ± 1.2 Å
	2f1v » Outer membrane protein W 25.4 ± 1.4 Å		1g5z » Outer surface protein C 3.6 ± 0.6 Å
	2w8h » Outer membrane lipoprotein Wza, water-soluble part 1.6 ± 0.2 Å		3gp6 » Lipid A acylase PagP 24.7 ± 1.5 Å
	3rbh » Alginate export protein, AlgE 23.4 ± 1.2 Å		4j3o » Outer membrane usher protein FimD, complex with FimC-FimF-FimG-FimH 23.8 ± 1.4 Å
	1kmp » Outer membrane transporter FecA, different conformation 24.9 ± 0.9 Å		1uyo » Autotransporter NalP, different conformation 23.6 ± 1.4 Å
	2erv » Lipid A deacylase PagL 24.7 ± 1.8 Å		2lhf » Outer membrane protein H (OprH) 20.6 ± 0.6 Å
	2gr7 » Autotransporter Hia, 992-1098 22.7 ± 2.0 Å		2grx » Ferric hydroxamate uptake receptor FhuA, complex with TonB 24.6 ± 1.1 Å
	2gsk » Outer membrane cobalamin transporter BtuB, complex with TonB 23.4 ± 0.7 Å		2iwv » Outer membrane protein G (OMPG), open state 1 25.3 ± 1.4 Å
	2iww » Outer membrane protein G (OMPG), closed state 24.7 ± 1.4 Å		2j1n » Osmoporin OMPC 25.1 ± 1.2 Å
	2j58 » Outer membrane lipoprotein Wza 31.1 ± 0.8 Å		2o4v » Porin OprP 23.9 ± 1.1 Å
	2hdi » Colicin I receptor complex with binding domain of Colicin Ia 23.4 ± 0.9 Å		2hdf » Colicin I receptor 23.4 ± 0.9 Å
	2ixx » Osmoporin OMPC, isoform 1 26.2 ± 1.3 Å		2ixw » Osmoporin OMPC, isoform 2 24.5 ± 1.0 Å
	2qdz » Filamentous hemagglutinin transporter FhaC 24.4 ± 1.1 Å		2odj » Outer membrane porin OprD 23.0 ± 0.8 Å
	2qom » Serine protease EspP, post-cleavage structure 25.1 ± 1.6 Å		2guf » Outer membrane cobalamin transporter BtuB, meso form 23.4 ± 0.9 Å
	3bry » Toluene transporter TbuX 25.4 ± 1.5 Å		3bs0 » Toluene transporter TodX 23.4 ± 1.4 Å
	2qtk » Protein OpdK 23.3 ± 1.0 Å		2y8p » Endo-type membrane-bound lytic murein transglycosylase A 0.0 ± 3.6 Å
	3emo » Autotransporter Hia, 937-1098, a different conformation 22.8 ± 1.9 Å		3dwo » FadL homologue 24.8 ± 1.6 Å
	3dzm » Major outer membrane protein from Thermus thermophilus 28.5 ± 2.6 Å		2k0l » Outer membrane protein A from Klebsiella 24.3 ± 2.3 Å
	3csl » Hemophore receptor HasR 25.4 ± 1.3 Å		3fid » Lipid A deacylase LpxR 25.6 ± 2.0 Å
	3efm » Outer membrane receptor FauA 24.7 ± 0.6 Å		3fhh » Outer membrane heme transporter ShuA 24.6 ± 0.9 Å
	2wjr » Acidic sugar-specific porin NanC 23.3 ± 1.5 Å		3jty » BenF-like porin 24.2 ± 1.2 Å
	2ysu » Outer membrane cobalamin transporter BtuB, complex with colicin E2 R-domain 24.2 ± 1.0 Å		1ujw » Outer membrane cobalamin transporter BtuB, complex with colicin E3 R-domain 23.6 ± 1.1 Å
	3kvn » Esterase EstA 24.4 ± 1.5 Å		3a2s » Porin B (PorB) 24.4 ± 1.0 Å
	3aeh » Hemoglobin-binding protease Hbp autotransporter 25.2 ± 1.1 Å		3jqo » Outer membrane complex of type IV secretion system (VirB7/VirB9/VirB10 complex) 22.6 ± 0.6 Å
	2bhv » TrbI protein 3.1 ± 1.3 Å		1qd5 » Outer membrane phospholipase A, monomer 24.6 ± 1.2 Å
	3m8d » Outer membrane cobalamin transporter BtuB, with cyanocobalamin 23.3 ± 0.8 Å		2x9k » Outer membrane protein G (OMPG), open state 2 24.7 ± 1.2 Å
	2x27 » Outer membrane protein OprG 23.9 ± 1.7 Å		3pik » Cation efflux system protein CusC 24.3 ± 1.2 Å
	3qq2 » Autotransporter BrkA 24.6 ± 1.5 Å		2xci » 3-Deoxy-D-manno-octulosonic-acid transferase, WaaA 8.3 ± 1.5 Å
	3pmq » Decaheme cytochrome c MtrF 3.9 ± 0.9 Å		3ohn » Outer membrane usher protein FimD 21.2 ± 1.1 Å
	3rfz » Outer membrane usher protein FimD, complex with FimC-FimH 23.8 ± 0.8 Å		3nsg » Porin OmpF 23.6 ± 0.8 Å
	3prw » Lipoprotein BamB 5.1 ± 1.2 Å		3tgo » BamCD lipoprotein complex 3.7 ± 2.1 Å
	3slj » Serine protease EspP, pre-cleavage structure 25.4 ± 1.2 Å		3ml3 » Outer membrane protein IcsA autotransporter 3.4 ± 0.5 Å
	2iou » Pertactin, complex with phage tail protein 3.9 ± 1.2 Å		1dab » Pertactin autotransporter 2.6 ± 1.1 Å
	3qra » Attachment invasion locus protein 25.2 ± 1.4 Å		3qrc » Attachment invasion locus protein, complex with the heparin analogue 24.6 ± 1.2 Å
	1ys5 » Factor H binding protein 3.5 ± 2.6 Å		3qlb » Enantio-pyochelin receptor FetA 23.4 ± 0.8 Å
	2y0h » Outer membrane porin OpdL 23.0 ± 1.0 Å		2y0k » Pyroglutamate porin OpdO 23.8 ± 1.2 Å
	2y0l » Cis-aconitate porin OpdH 21.4 ± 1.5 Å		3p1l » Lipoprotein yfgL 3.6 ± 2.8 Å
	1kv9 » Quinohemoprotein alcohol dehydrogenase ADH IIB 1.7 ± 1.1 Å		1sr4 » Cytolethal distending toxin complex 1.8 ± 1.5 Å
	3sy9 » Histidine porin OpdC 23.4 ± 0.8 Å		3syb » Glycine-glutamate dipeptide porin OpdP 23.6 ± 0.9 Å
	3szd » Porin OpdF 22.0 ± 1.6 Å		3t24 » Porin OpdQ 23.0 ± 1.3 Å
	3v89 » Transferrin-binding protein A, complex with human serotransferrin 22.8 ± 0.8 Å		3v8x » Transferrin-binding protein A, complex with full-length transferrin 23.2 ± 0.6 Å
	4e1s » Intimin 24.4 ± 1.6 Å		4e1t » Invasin 25.6 ± 1.4 Å
	4epa » Pesticin receptor FyuA 23.6 ± 0.8 Å		4aui » Porin B (PorB) 24.2 ± 0.8 Å
	4gey » Porin B 24.2 ± 1.6 Å		4gf4 » Porin B, low pH structure 22.4 ± 1.1 Å
	2lme » Adhesin yadA 23.4 ± 2.2 Å		3upg » Osmoporin OMPC 23.4 ± 0.7 Å
	4aip » Fe-regulated protein B 23.4 ± 0.3 Å		4aiq » Fe-regulated protein B, different variant 23.6 ± 0.9 Å
	4afk » Alginate export protein, AlgE, different conformation of loops 24.8 ± 0.9 Å		3k8i » Lipoprotein TP0453, open conformation 8.9 ± 2.4 Å
	1bxw » Outer membrane protein A (OMPA) 25.4 ± 1.9 Å		1thq » Lipid A acylase PagP, different conformation of loops 23.4 ± 2.5 Å
	2vdf » Outer membrane adhesin/invasin OpcA, disordered loops 24.8 ± 1.2 Å		2x4m » Plasminogen activator PLA (coagulase/fibrinolysin), disordered loop 24.2 ± 1.6 Å
	3pgr » Fatty Acid Transporter FadL, D348R, open channel 25.4 ± 1.4 Å		3pgu » Fatty Acid Transporter FadL, F3E, open channel 25.2 ± 1.5 Å
	2r88 » Fatty Acid Transporter FadL, delS3, open channel 24.0 ± 1.4 Å		2wmz » Outer membrane protein TolC, mutant, open conformation 1 24.4 ± 0.8 Å
	2vdd » Outer membrane protein TolC, mutant, open conformation 3 24.4 ± 1.2 Å		2xmn » Outer membrane protein TolC, mutant, open conformation 4 23.6 ± 1.4 Å
	3njt » Filamentous hemagglutinin transporter FhaC, R450A, disordered loops 23.6 ± 0.9 Å		3sy7 » Outer membrane porin OprD, different conformation of loops 23.8 ± 1.1 Å
	3k8g » Lipoprotein TP0453, closed conformation 6.9 ± 2.8 Å		3k8j » Lipoprotein TP0453, intermediate conformation 5.4 ± 1.4 Å
	Bacterial gram-negative outer membrane

Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24. Membrane lipids: where they are and how they behave.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA