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• LIPID COMPOSITION ATLAS

• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

• Protein Links

• PDB Sum,
• PDB,
• OCA,
• MPKS,
• PDBTM,
• MPDB,
• CGDB

Membrane Protein Lipid Composition Atlas

1.		Archaebacterial membrane (54 proteins)
2.		Bacterial Gram-negative inner membrane (269 proteins)
3.		Bacterial Gram-negative outer membrane (136 proteins)
4.		Bacterial Gram-positive outer membrane (7 proteins)
5.		Bacterial Gram-positive plasma membrane (81 proteins)
6.		Chloroplast inner membrane (1 protein)
7.		Chloroplast outer membrane (0 proteins)
8.		Cytoplasmic granule membrane (1 protein)
9.		Endoplasmic reticulum membrane (125 proteins)
10.		Endosome membrane (35 proteins)
11.		Eukaryotic plasma membrane (479 proteins)
12.		Golgi membrane (22 proteins)
13.		Lysosome membrane (17 proteins)
14.		Mitochondrial inner membrane (51 proteins)
15.		Mitochondrial outer membrane (20 proteins)
16.		Nuclear inner membrane (3 proteins)
17.		Nuclear outer membrane (5 proteins)
18.		Peroxisome membrane (10 proteins)
19.		Secreted (681 proteins)
20.		Thylakoid membrane (31 proteins)
21.		Undefined (75 proteins)
22.		Vacuole membrane (16 proteins)
23.		Vesicle membrane (13 proteins)
24.		Viral membrane (40 proteins)

Lipid Composition in Endoplasmic reticulum membrane

Cell/Species	PC %	PE %	PI %	PS %	PA %	CL %	Sph %	Ch %	CB %	SL %	PI+PS %	PI+LPE %	LPC %	PG %
Rat Liver (male Wistar) Rattus norvegicus	53.0	20.2	-	-	-	-	3.7	-	-	-	14.1	-	-	-
Barley Roots Hordeum vulgare	58.0	20.9	-	1.4	1.0	-	-	-	-	-	-		2.2	6.4
Light Microsomes Saccharomyces cerevisiae	51.3	33.4	7.5	6.6	0.2	0.4	-	-	-	-	-	-	-	-

Endoplasmic reticulum membrane

	2jo1 » Na,K-ATPase regulatory protein FXYD1 (phospholemman) 30.6 ± 2.5 Å		3ar2 » Calcium ATPase, E1-2Ca state, conformation 1 29.6 ± 0.9 Å
	1wpg » Calcium ATPase, E2-Pi state, conformation 1 30.6 ± 1.1 Å		1t5s » Calcium ATPase, E1-ATP state 29.7 ± 1.6 Å
	2zbd » Calcium ATPase, E1P-ADP state 31.8 ± 1.4 Å		1p49 » Steryl-sulfatase 29.6 ± 1.1 Å
	1mt5 » Fatty acid amide hydrolase 11.1 ± 0.2 Å		1cx2 » Prostaglandin H2 synthase-2 (cyclooxygenase) 9.7 ± 0.4 Å
	1zll » Phospholamban 30.5 ± 1.4 Å		2agv » Calcium ATPase, E2 state (Ca-free), conformation 1 29.7 ± 2.2 Å
	1jdm » Sarcolipin 29.6 ± 2.4 Å		1q4g » Prostaglandin H2 synthase-1 8.9 ± 0.4 Å
	1w6k » Lanosterol synthase 7.6 ± 1.0 Å		1nr6 » Cytochrome P450 2C5 10.6 ± 1.0 Å
	1suo » Cytochrome P450 2B4, closed state 1 4.6 ± 1.3 Å		1pq2 » Cytochrome P450 2C8 3.8 ± 1.8 Å
	1og5 » Cytochrome P450 2C9 7.6 ± 1.0 Å		1tqn » Cytochrome P450 3A4, conformation 1 8.7 ± 1.0 Å
	1z10 » Cytochrome P450 2A6 5.0 ± 1.7 Å		3o22 » Prostaglandin-H2 D-isomerase 0.7 ± 1.2 Å
	2wx2 » Sterol 14-alpha-demethylase (CYP51), conformation 2 5.9 ± 5.9 Å		2kb7 » Phospholamban, monomer 32.0 ± 2.2 Å
	1rkl » Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4 (OST4) 24.8 ± 3.2 Å		2lat » Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4 (OST4) 31.8 ± 3.5 Å
	3sja » ATPase Get3, complex with Get1 cytosolic domain 6.4 ± 1.6 Å		2yd0 » Endoplasmic reticulum aminopeptidase 1, different conformation 4.1 ± 2.2 Å
	3mdj » Endoplasmic reticulum aminopeptidase 1 1.9 ± 3.6 Å		1po5 » Cytochrome P450 2B4, open state 2 3.5 ± 1.4 Å
	1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1 4.6 ± 0.4 Å		1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1 7.9 ± 0.2 Å
	3ar8 » Calcium ATPase, E2-Pi state, conformation 2 28.6 ± 1.8 Å		3sn5 » Cholesterol 7-alpha-monooxygenase (P450 7A1), different conformation 6.0 ± 1.9 Å
	2ktd » Prostaglandin-H2 D-isomerase 0.0 ± 1.4 Å		1nrj » Signal recognition particle receptor 3.9 ± 1.4 Å
	2f9q » Cytochrome P450 2D6, conformation 1 7.0 ± 1.8 Å		2bdm » Cytochrome P450 2B4, open state 1 10.6 ± 1.0 Å
	1r9o » Cytochrome P450 2C9, different conformation 4.0 ± 1.1 Å		1dt6 » Cytochrome P450 2C5, different conformation 7.3 ± 1.0 Å
	2uuh » Leukotriene C4 synthase 29.4 ± 1.1 Å		3a36 » ATPase Get3, homodimer 5.6 ± 3.0 Å
	1r7g » Nonstructural protein 5a, segment 1973-2003 of polyprotein 5.3 ± 0.9 Å		2ajo » Nonstructural protein 5a 5.0 ± 1.0 Å
	1plp » Phospholamban, cytoplasmic helix 4.0 ± 1.3 Å		2h8a » Microsomal glutathione S-transferase 1 29.7 ± 0.7 Å
	2q7r » FLAP protein (5-lipoxygenase activator) 30.3 ± 1.3 Å		2hi4 » Cytochrome P450 1A2 6.9 ± 1.0 Å
	3b6h » Prostacyclin synthase (cytochrome P450 8A1) 5.0 ± 1.6 Å		3b9b » Calcium ATPase, E2-Pi state, conformation 3 29.9 ± 1.6 Å
	3e6i » Cytochrome P450 2E1 8.3 ± 2.0 Å		3czh » Cytochrome P450 2R1 8.3 ± 1.5 Å
	2q9f » Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 1 2.8 ± 1.0 Å		3g49 » Corticosteroid 11-beta-dehydrogenase, isozyme 1 7.0 ± 0.5 Å
	3dww » Microsomal prostaglandin E synthase 1 31.9 ± 1.1 Å		3eqm » Cytochrome P450 19A1 (aromatase, estrogen synthetase) 6.1 ± 1.2 Å
	3ld6 » Sterol 14-alpha-demethylase (CYP51) 8.9 ± 0.6 Å		2jp3 » Na,K-ATPase regulatory protein FXYD1 (phospholemman) 31.8 ± 3.2 Å
	3g1q » Sterol 14-alpha-demethylase (CYP51) 8.1 ± 1.5 Å		2wuz » Sterol 14-alpha-demethylase (CYP51), conformation 1 4.0 ± 1.1 Å
	3l4d » Sterol 14-alpha-demethylase (CYP51) 8.4 ± 1.8 Å		2wwb » Protein translocase Sec61, complex with ribosome 26.3 ± 0.5 Å
	3ar9 » Calcium ATPase, E2 state, Ca-free, conformation 7 29.0 ± 0.9 Å		3mdm » Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 2 3.8 ± 1.3 Å
	3nxu » Cytochrome P450 3A4, conformation 2 9.3 ± 1.0 Å		1rp4 » Endoplasmic reticulum oxidoreductin 2.0 ± 1.8 Å
	3m31 » Endoplasmic reticulum oxidoreductin, a mutant 1.9 ± 1.2 Å		1fjk » Phosholamban 30.1 ± 3.2 Å
	1n7l » Phospholamban 29.8 ± 3.6 Å		3fo5 » Acyl-coenzyme A thioesterase 11 2.3 ± 1.4 Å
	3ibd » Cytochrome P450 2B6 4.7 ± 1.0 Å		3dax » Cholesterol 7-alpha-monooxygenase (P450 7A1) 1.8 ± 1.9 Å
	3pm0 » Cytochrome P450 1B1 3.8 ± 0.7 Å		2p85 » Cytochrome P450 2A13 4.9 ± 0.4 Å
	3r1b » Cytochrome P450 2B4, open state 3 5.7 ± 0.0 Å		2kdr » Nonstructural protein 4b, segment 1938-1965 of polyprotein 22.4 ± 2.0 Å
	2jy0 » NS2 protease, segment 810-837 of polyprotein 23.8 ± 2.9 Å		2kwz » NS2 protease, segment 869-908 of polyprotein 29.8 ± 1.6 Å
	2kwt » NS2 protease, segment 836-868 of polyprotein 9.5 ± 3.6 Å		2jxf » Nonstructural protein 4b, segment 1751-1780 of polyprotein 5.6 ± 3.6 Å
	1qlo » ICP47 protein, active domain (1-34) 8.6 ± 0.8 Å		2x43 » Small hydrophilic endoplasmic reticulum-associated protein (Sherp) 4.1 ± 0.3 Å
	3se6 » Endoplasmic reticulum aminopeptidase 2 2.5 ± 1.8 Å		3swz » Steroid 17-alpha-hydroxylase/17,20 lyase (P450 17A1) 4.2 ± 1.6 Å
	2wfm » Polyneuridine-aldehyde esterase 2.5 ± 1.7 Å		3p8n » HCV serine protease NS3 8.7 ± 1.7 Å
	2o8m » Hepatitis C virus NS3 protease 5.0 ± 1.3 Å		2whx » Serine protease/helicase NS3 4.4 ± 2.3 Å
	2wv9 » Flavivirin protease NS2B 1.6 ± 2.4 Å		2hd0 » Hepatitis C virus non-structural protein NS2 6.7 ± 0.6 Å
	3fqm » Non-structural protein 5A 4.9 ± 1.1 Å		3qz1 » Steroid 21-hydroxylase (P450 C21) 5.9 ± 1.6 Å
	1tpz » Interferon-inducible GTPase 1 2.5 ± 2.0 Å		2bcg » Secretory pathway GDP dissociation inhibitor 3.5 ± 1.0 Å
	3ca7 » Protein spitz 3.3 ± 2.8 Å		3qm4 » Cytochrome P450 2D6, conformation 3 9.0 ± 1.4 Å
	3tgh » Glideosome-associated protein 50 4.2 ± 3.4 Å		3tlm » Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 26.8 ± 0.0 Å
	4aw6 » CAAX prenyl protease 1 homolog 30.8 ± 1.3 Å		3tda » Cytochrome P450 2D6, conformation 2 8.0 ± 0.7 Å
	3ua5 » Cytochrome P450 2B6, different conformation 4.7 ± 1.1 Å		2lm7 » Peptide of outer capsid glycoprotein VP7 (266-326) 10.2 ± 1.5 Å
	4il3 » CaaX Protease Ste24p 29.8 ± 1.4 Å		4hhr » Alpha-dioxygenase 1 10.8 ± 0.1 Å
	4i8v » Cytochrome P450 1A1 7.1 ± 1.0 Å		4fmm » Phosphatidylinositol transfer protein PDR16 9.9 ± 2.6 Å
	3w5a » Calcium ATPase, E1 Mg2+ state, complex with sarcolipin 26.8 ± 0.7 Å		4h1w » Calcium ATPase, E1 Ca2+ state, complex with sarcolipin 27.6 ± 1.0 Å
	2by4 » Calcium ATPase, E2 state (Ca-free), conformation 2 29.8 ± 1.3 Å		2ear » Calcium ATPase, E2 state, Ca-free, conformation 3 30.0 ± 1.2 Å
	3fps » Calcium ATPase, E2 state (Ca-free), conformation 4 30.0 ± 0.9 Å		1kju » Calcium ATPase, E2 state (Ca-free), conformation 5 33.8 ± 0.2 Å
	2zbe » Calcium ATPase, E2 state (Ca-free), conformation 6 28.0 ± 0.7 Å		2zbg » Calcium ATPase, E2 state (Ca-free), conformation 8 30.0 ± 1.7 Å
	3b9r » Calcium ATPase, E2-Pi state, conformation 4 26.8 ± 0.0 Å		3fpb » Calcium ATPase, E2-Pi state, conformation 5 27.0 ± 2.3 Å
	1xp5 » Calcium ATPase, E2-Pi state, conformation 6 27.4 ± 1.1 Å		3n5k » Calcium ATPase, E2-Pi state, conformation 7 28.4 ± 1.3 Å
	3ba6 » Calcium ATPase, E1-2Ca state, conformation 2 29.8 ± 0.7 Å		1su4 » Calcium ATPase, E1-2Ca state, conformation 3 30.0 ± 2.7 Å
	2c9m » Calcium ATPase, E1-2Ca state, conformation 4 29.8 ± 1.2 Å		3ksw » Sterol 14-alpha-demethylase (CYP51), conformation 3 8.0 ± 6.7 Å
	2q6n » Cytochrome P450 2B4, closed state 2 5.5 ± 0.4 Å		3g5n » Cytochrome P450 2B4, closed state 3 5.7 ± 1.8 Å
	2ko2 » Reticulon-4 2.5 ± 0.3 Å		3v66 » Squalene synthase, conformation 1 3.1 ± 0.8 Å
	3vjc » Squalene synthase, conformation 2 7.3 ± 0.9 Å
	Endoplasmic reticulum membrane

Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24. Membrane lipids: where they are and how they behave.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA