PDB ID or protein name

Membrane Protein Lipid Composition Atlas

1. Archaebacterial membrane (74 proteins)
2. Bacterial Gram-negative inner membrane (337 proteins)
3. Bacterial Gram-negative outer membrane (169 proteins)
4. Bacterial Gram-positive outer membrane (7 proteins)
5. Bacterial Gram-positive plasma membrane (110 proteins)
6. Chloroplast inner membrane (1 protein)
7. Chloroplast outer membrane (1 protein)
8. Cytoplasmic granule membrane (1 protein)
9. Endoplasmic reticulum membrane (157 proteins)
10. Endosome membrane (42 proteins)
11. Eukaryotic plasma membrane (598 proteins)
12. Golgi membrane (29 proteins)
13. Lysosome membrane (17 proteins)
14. Mitochondrial inner membrane (57 proteins)
15. Mitochondrial outer membrane (24 proteins)
16. Nuclear inner membrane (3 proteins)
17. Nuclear outer membrane (6 proteins)
18. Peroxisome membrane (11 proteins)
19. Secreted (779 proteins)
20. Thylakoid membrane (34 proteins)
21. Undefined (88 proteins)
22. Vacuole membrane (19 proteins)
23. Vesicle membrane (15 proteins)
24. Viral membrane (44 proteins)

Lipid Composition in Mitochondrial inner membrane

Cell/Species PC % PE % PI % PS % PA % CL % Sph % Ch % CB % SL % PI+PS % PI+LPE % LPC % PG %
Budding Yeast
Saccharomyces cerevisiae
38.4 24.0 16.2 3.8 1.5 16.1 - - - - - - - -

Mitochondrial inner membrane

corner lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid corner
lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid
2dyr » Mitochondrial cytochrome c oxidase 2dyr » Mitochondrial cytochrome c oxidase
28.0 ± 0.6 Å
spacer 1l0l » Cytochrome bc1, mitochondrial, structure 1
30.0 ± 0.6 Å
1l0l » Cytochrome bc1, mitochondrial, structure 1
lipid
lipid
  spacer   lipid
lipid
3cx5 » Cytochrome bc1, mitochondrial, structure 1 3cx5 » Cytochrome bc1, mitochondrial, structure 1
27.2 ± 0.6 Å
spacer 1okc » Mitochondrial ADP-ATP carrier
29.5 ± 1.7 Å
1okc » Mitochondrial ADP-ATP carrier
lipid
lipid
  spacer   lipid
lipid
1d3h » Dihydroorotate dehydrogenase 1d3h » Dihydroorotate dehydrogenase
3.4 ± 0.8 Å
spacer 1zoy » Succinate dehydrogenase (mitochondrial respiratory complex II)
29.8 ± 1.1 Å
1zoy » Succinate dehydrogenase (mitochondrial respiratory complex II)
lipid
lipid
  spacer   lipid
lipid
1pp9 » Cytochrome bc1, mitochondrial, structure 3 1pp9 » Cytochrome bc1, mitochondrial, structure 3
29.8 ± 0.3 Å
spacer 1yq3 » Succinate dehydrogenase (mitochondrial respiratory complex II)
29.6 ± 1.8 Å
1yq3 » Succinate dehydrogenase (mitochondrial respiratory complex II)
lipid
lipid
  spacer   lipid
lipid
1hrc » Mitochondrial cytochrome c 1hrc » Mitochondrial cytochrome c
2.1 ± 1.0 Å
spacer 3w54 » Alternative oxidase
9.7 ± 0.3 Å
3w54 » Alternative oxidase
lipid
lipid
  spacer   lipid
lipid
1lcy » Mitochondrial serine protease HtrA2 1lcy » Mitochondrial serine protease HtrA2
7.4 ± 1.8 Å
spacer 1uum » Dihydroorotate dehydrogenase
6.9 ± 0.4 Å
1uum » Dihydroorotate dehydrogenase
lipid
lipid
  spacer   lipid
lipid
1e6e » Adrenodoxin reductase of mitochondrial p450 systems, complex with adrenodoxin 1e6e » Adrenodoxin reductase of mitochondrial p450 systems, complex with adrenodoxin
2.3 ± 1.0 Å
spacer 1sez » Protoporphyrinogen oxidase
2.2 ± 1.0 Å
1sez » Protoporphyrinogen oxidase
lipid
lipid
  spacer   lipid
lipid
2xok » F1F0 ATP synthase, F0F1 complex 2xok » F1F0 ATP synthase, F0F1 complex
35.3 ± 1.3 Å
spacer 1efv » Electron transfer flavoprotein
4.6 ± 1.3 Å
1efv » Electron transfer flavoprotein
lipid
lipid
  spacer   lipid
lipid
1hrk » Ferrochelatase, conformation 1 1hrk » Ferrochelatase, conformation 1
2.7 ± 0.1 Å
spacer 2hn8 » Protein PB1-F2, mitochondrial targeting peptide (50-87)
5.1 ± 3.8 Å
2hn8 » Protein PB1-F2, mitochondrial targeting peptide (50-87)
lipid
lipid
  spacer   lipid
lipid
2lck » Mitochondrial uncoupling protein 2 2lck » Mitochondrial uncoupling protein 2
30.0 ± 1.2 Å
spacer 2h4t » Carnitine O-palmitoyltransferase 2
4.0 ± 1.2 Å
2h4t » Carnitine O-palmitoyltransferase 2
lipid
lipid
  spacer   lipid
lipid
3i65 » Dihydroorotate dehydrogenase 3i65 » Dihydroorotate dehydrogenase
5.1 ± 1.0 Å
spacer 2gmh » Flavoprotein-ubiquinone oxydoreductase
7.2 ± 0.8 Å
2gmh » Flavoprotein-ubiquinone oxydoreductase
lipid
lipid
  spacer   lipid
lipid
3k9v » Cytochrome P450 24a1 (1,25-dihydroxyvitamin D(3) 24-hydroxylase) 3k9v » Cytochrome P450 24a1 (1,25-dihydroxyvitamin D(3) 24-hydroxylase)
6.6 ± 1.0 Å
spacer 3h1j » Cytochrome bc1, mitochondrial, structure 1
28.2 ± 0.6 Å
3h1j » Cytochrome bc1, mitochondrial, structure 1
lipid
lipid
  spacer   lipid
lipid
1ndb » Carnitine O-acetyltransferase 1ndb » Carnitine O-acetyltransferase
3.0 ± 0.9 Å
spacer 1nm8 » Carnitine O-octanoyltransferase
1.7 ± 3.0 Å
1nm8 » Carnitine O-octanoyltransferase
lipid
lipid
  spacer   lipid
lipid
2h3u » Carnitine O-acetyltransferase, complex with substrate 2h3u » Carnitine O-acetyltransferase, complex with substrate
3.0 ± 1.0 Å
spacer 3n9y » Cholesterol side-chain cleavage enzyme (P450 11A1), complex with adrenodoxin
4.1 ± 0.6 Å
3n9y » Cholesterol side-chain cleavage enzyme (P450 11A1), complex with adrenodoxin
lipid
lipid
  spacer   lipid
lipid
3mzs » Cholesterol side-chain cleavage enzyme (P450 11A1) 3mzs » Cholesterol side-chain cleavage enzyme (P450 11A1)
3.2 ± 0.3 Å
spacer 4ayt » Mitochondrial ABC transporter ABCB10, conformation 1
30.4 ± 0.8 Å
4ayt » Mitochondrial ABC transporter ABCB10, conformation 1
lipid
lipid
  spacer   lipid
lipid
2ybb » EM model of mitochondrial supercomplex 2ybb » EM model of mitochondrial supercomplex
30.0 ± 0.3 Å
spacer 3rgq » Protein-tyrosine phosphatase, mitochondrial 1
1.7 ± 0.7 Å
3rgq » Protein-tyrosine phosphatase, mitochondrial 1
lipid
lipid
  spacer   lipid
lipid
4ayw » Mitochondrial ABC transporter ABCB10, conformation 2 4ayw » Mitochondrial ABC transporter ABCB10, conformation 2
29.0 ± 0.8 Å
spacer 1lbq » Ferrochelatase, mitochondrial
5.3 ± 0.5 Å
1lbq » Ferrochelatase, mitochondrial
lipid
lipid
  spacer   lipid
lipid
2bmb » Folic acid synthesis protein FOL1 2bmb » Folic acid synthesis protein FOL1
2.0 ± 0.6 Å
spacer 2vn8 » Reticulon-4-interacting protein 1
4.0 ± 0.0 Å
2vn8 » Reticulon-4-interacting protein 1
lipid
lipid
  spacer   lipid
lipid
2wsi » FAD synthase 2wsi » FAD synthase
3.3 ± 1.7 Å
spacer 3nks » Protoporphyrinogen oxidase
4.8 ± 1.0 Å
3nks » Protoporphyrinogen oxidase
lipid
lipid
  spacer   lipid
lipid
2lop » Transmembrane proteins 14A 2lop » Transmembrane proteins 14A
28.8 ± 2.0 Å
spacer 2los » Transmembrane protein 14C
26.8 ± 0.4 Å
2los » Transmembrane protein 14C
lipid
lipid
  spacer   lipid
lipid
4ayx » Mitochondrial ABC transporter ABCB10, conformation 3 4ayx » Mitochondrial ABC transporter ABCB10, conformation 3
30.0 ± 0.6 Å
spacer 3vr8 » Succinate dehydrogenase (mitochondrial respiratory complex II)
30.4 ± 1.2 Å
3vr8 » Succinate dehydrogenase (mitochondrial respiratory complex II)
lipid
lipid
  spacer   lipid
lipid
4f4s » F1F0 ATP synthase, F0 complex 4f4s » F1F0 ATP synthase, F0 complex
38.4 ± 1.3 Å
spacer 4g6h » Rotenone-insensitive NADH-ubiquinone oxidoreductase, NDI1
4.8 ± 0.0 Å
4g6h » Rotenone-insensitive NADH-ubiquinone oxidoreductase, NDI1
lipid
lipid
  spacer   lipid
lipid
4b2q » F1F0 ATP synthase, F0F1 complex, more complete model 4b2q » F1F0 ATP synthase, F0F1 complex, more complete model
38.4 ± 0.9 Å
spacer 4dvq » Cytochrome P450 11B2, mitochondrial
4.8 ± 0.6 Å
4dvq » Cytochrome P450 11B2, mitochondrial
lipid
lipid
  spacer   lipid
lipid
2fyu » Cytochrome bc1, mitochondrial, structure 2 2fyu » Cytochrome bc1, mitochondrial, structure 2
29.8 ± 0.5 Å
spacer 2a06 » Cytochrome bc1, structure 4
29.8 ± 0.3 Å
2a06 » Cytochrome bc1, structure 4
lipid
lipid
  spacer   lipid
lipid
3zry » F1F0 ATP synthase, F0F1 complex, different conformation 3zry » F1F0 ATP synthase, F0F1 complex, different conformation
33.6 ± 1.9 Å
spacer 3zdq » Mitochondrial ABC transporter ABCB10, conformation 4
30.8 ± 0.5 Å
3zdq » Mitochondrial ABC transporter ABCB10, conformation 4
lipid
lipid
  spacer   lipid
lipid
2c3e » Mitochondrial ADP-ATP carrier, with carboxyatractyloside 2c3e » Mitochondrial ADP-ATP carrier, with carboxyatractyloside
30.0 ± 1.0 Å
spacer 4c9g » Mitochondrial ADP-ATP carrier, conformation 1
31.4 ± 1.5 Å
4c9g » Mitochondrial ADP-ATP carrier, conformation 1
lipid
lipid
  spacer   lipid
lipid
4c9q » Mitochondrial ADP-ATP carrier, conformation 2 4c9q » Mitochondrial ADP-ATP carrier, conformation 2
30.2 ± 1.1 Å
spacer 4c9h » Mitochondrial ADP-ATP carrier, dimer, conformation 1
30.4 ± 0.7 Å
4c9h » Mitochondrial ADP-ATP carrier, dimer, conformation 1
lipid
lipid
  spacer   lipid
lipid
4myc » Iron-sulfur clusters transporter ATM1 4myc » Iron-sulfur clusters transporter ATM1
30.8 ± 1.4 Å
spacer 4klr » Ferrochelatase, conformation 2 (with porphyrin bound)
1.3 ± 0.0 Å
4klr » Ferrochelatase, conformation 2 (with porphyrin bound)
lipid
lipid
  spacer   lipid
lipid
4cq8 » Dihydroorotate dehydrogenase, structure 2 4cq8 » Dihydroorotate dehydrogenase, structure 2
4.9 ± 0.4 Å
spacer   lipid
lipid
corner Mitochondrial inner membrane corner
Membrane Lipid Composition
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24. Membrane lipids: where they are and how they behave.