PDB ID or protein name

Membrane Protein Lipid Composition Atlas

1. Archaebacterial membrane (79 proteins)
2. Bacterial Gram-negative inner membrane (361 proteins)
3. Bacterial Gram-negative outer membrane (182 proteins)
4. Bacterial Gram-positive outer membrane (8 proteins)
5. Bacterial Gram-positive plasma membrane (122 proteins)
6. Chloroplast inner membrane (1 protein)
7. Chloroplast outer membrane (1 protein)
8. Cytoplasmic granule membrane (1 protein)
9. Endoplasmic reticulum membrane (165 proteins)
10. Endosome membrane (52 proteins)
11. Eukaryotic plasma membrane (661 proteins)
12. Golgi membrane (30 proteins)
13. Lysosome membrane (20 proteins)
14. Mitochondrial inner membrane (61 proteins)
15. Mitochondrial outer membrane (29 proteins)
16. Nuclear inner membrane (3 proteins)
17. Nuclear outer membrane (6 proteins)
18. Peroxisome membrane (11 proteins)
19. Secreted (840 proteins)
20. Thylakoid membrane (36 proteins)
21. Undefined (94 proteins)
22. Vacuole membrane (23 proteins)
23. Vesicle membrane (16 proteins)
24. Viral membrane (52 proteins)

Lipid Composition in Mitochondrial inner membrane

Cell/Species PC % PE % PI % PS % PA % CL % Sph % Ch % CB % SL % PI+PS % PI+LPE % LPC % PG %
Budding Yeast
Saccharomyces cerevisiae
38.4 24.0 16.2 3.8 1.5 16.1 - - - - - - - -

Mitochondrial inner membrane

corner lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid corner
lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid
2dyr » Mitochondrial cytochrome c oxidase 2dyr » Mitochondrial cytochrome c oxidase
28.0 ± 0.6 Å
spacer 1l0l » Cytochrome bc1, mitochondrial, structure 1
30.0 ± 0.6 Å
1l0l » Cytochrome bc1, mitochondrial, structure 1
lipid
lipid
  spacer   lipid
lipid
3cx5 » Cytochrome bc1, mitochondrial, with cytochrome c iso-1 3cx5 » Cytochrome bc1, mitochondrial, with cytochrome c iso-1
27.2 ± 0.6 Å
spacer 1okc » Mitochondrial ADP-ATP carrier
29.5 ± 1.7 Å
1okc » Mitochondrial ADP-ATP carrier
lipid
lipid
  spacer   lipid
lipid
1d3h » Dihydroorotate dehydrogenase 1d3h » Dihydroorotate dehydrogenase
3.4 ± 0.8 Å
spacer 1zoy » Succinate dehydrogenase (mitochondrial respiratory complex II)
29.8 ± 1.1 Å
1zoy » Succinate dehydrogenase (mitochondrial respiratory complex II)
lipid
lipid
  spacer   lipid
lipid
1pp9 » Cytochrome bc1, mitochondrial, structure 3 1pp9 » Cytochrome bc1, mitochondrial, structure 3
29.8 ± 0.4 Å
spacer 1yq3 » Succinate dehydrogenase (mitochondrial respiratory complex II)
29.6 ± 1.8 Å
1yq3 » Succinate dehydrogenase (mitochondrial respiratory complex II)
lipid
lipid
  spacer   lipid
lipid
1hrc » Mitochondrial cytochrome c 1hrc » Mitochondrial cytochrome c
2.1 ± 1.0 Å
spacer 3w54 » Alternative oxidase
9.7 ± 0.3 Å
3w54 » Alternative oxidase
lipid
lipid
  spacer   lipid
lipid
1lcy » Mitochondrial serine protease HtrA2 1lcy » Mitochondrial serine protease HtrA2
7.4 ± 1.8 Å
spacer 4xiz » Ups1 transporter-Mdm35 complex
2.0 ± 1.7 Å
4xiz » Ups1 transporter-Mdm35 complex
lipid
lipid
  spacer   lipid
lipid
1uum » Dihydroorotate dehydrogenase 1uum » Dihydroorotate dehydrogenase
6.9 ± 0.4 Å
spacer 1e6e » Adrenodoxin reductase of mitochondrial p450 systems, complex with adrenodoxin
2.3 ± 1.0 Å
1e6e » Adrenodoxin reductase of mitochondrial p450 systems, complex with adrenodoxin
lipid
lipid
  spacer   lipid
lipid
1sez » Protoporphyrinogen oxidase 1sez » Protoporphyrinogen oxidase
2.2 ± 1.0 Å
spacer 2xok » F1F0 ATP synthase, F0F1 complex
35.3 ± 1.3 Å
2xok » F1F0 ATP synthase, F0F1 complex
lipid
lipid
  spacer   lipid
lipid
1efv » Electron transfer flavoprotein 1efv » Electron transfer flavoprotein
4.6 ± 1.3 Å
spacer 1hrk » Ferrochelatase, conformation 1
2.7 ± 0.1 Å
1hrk » Ferrochelatase, conformation 1
lipid
lipid
  spacer   lipid
lipid
2hn8 » Protein PB1-F2, mitochondrial targeting peptide (50-87) 2hn8 » Protein PB1-F2, mitochondrial targeting peptide (50-87)
5.1 ± 3.8 Å
spacer 2lck » Mitochondrial uncoupling protein 2
30.0 ± 1.2 Å
2lck » Mitochondrial uncoupling protein 2
lipid
lipid
  spacer   lipid
lipid
2h4t » Carnitine O-palmitoyltransferase 2 2h4t » Carnitine O-palmitoyltransferase 2
4.0 ± 1.2 Å
spacer 3i65 » Dihydroorotate dehydrogenase
5.1 ± 1.0 Å
3i65 » Dihydroorotate dehydrogenase
lipid
lipid
  spacer   lipid
lipid
2gmh » Flavoprotein-ubiquinone oxydoreductase 2gmh » Flavoprotein-ubiquinone oxydoreductase
7.2 ± 0.8 Å
spacer 3k9v » Cytochrome P450 24a1 (1,25-dihydroxyvitamin D(3) 24-hydroxylase)
6.6 ± 1.0 Å
3k9v » Cytochrome P450 24a1 (1,25-dihydroxyvitamin D(3) 24-hydroxylase)
lipid
lipid
  spacer   lipid
lipid
3h1j » Cytochrome bc1, mitochondrial 3h1j » Cytochrome bc1, mitochondrial
28.2 ± 0.6 Å
spacer 1ndb » Carnitine O-acetyltransferase
3.0 ± 0.9 Å
1ndb » Carnitine O-acetyltransferase
lipid
lipid
  spacer   lipid
lipid
1nm8 » Carnitine O-octanoyltransferase 1nm8 » Carnitine O-octanoyltransferase
1.7 ± 3.0 Å
spacer 2h3u » Carnitine O-acetyltransferase, complex with substrate
3.0 ± 1.0 Å
2h3u » Carnitine O-acetyltransferase, complex with substrate
lipid
lipid
  spacer   lipid
lipid
3n9y » Cholesterol side-chain cleavage enzyme (P450 11A1), complex with adrenodoxin 3n9y » Cholesterol side-chain cleavage enzyme (P450 11A1), complex with adrenodoxin
4.1 ± 0.6 Å
spacer 3mzs » Cholesterol side-chain cleavage enzyme (P450 11A1)
3.2 ± 0.3 Å
3mzs » Cholesterol side-chain cleavage enzyme (P450 11A1)
lipid
lipid
  spacer   lipid
lipid
4ayt » Mitochondrial ABC transporter ABCB10, conformation 1 4ayt » Mitochondrial ABC transporter ABCB10, conformation 1
30.4 ± 0.8 Å
spacer 2ybb » EM model of mitochondrial supercomplex
30.0 ± 0.3 Å
2ybb » EM model of mitochondrial supercomplex
lipid
lipid
  spacer   lipid
lipid
3rgq » Protein-tyrosine phosphatase, mitochondrial 1 3rgq » Protein-tyrosine phosphatase, mitochondrial 1
1.7 ± 0.7 Å
spacer 4ayw » Mitochondrial ABC transporter ABCB10, conformation 2
29.0 ± 0.8 Å
4ayw » Mitochondrial ABC transporter ABCB10, conformation 2
lipid
lipid
  spacer   lipid
lipid
1lbq » Ferrochelatase, mitochondrial 1lbq » Ferrochelatase, mitochondrial
5.3 ± 0.5 Å
spacer 2bmb » Folic acid synthesis protein FOL1
2.0 ± 0.6 Å
2bmb » Folic acid synthesis protein FOL1
lipid
lipid
  spacer   lipid
lipid
2vn8 » Reticulon-4-interacting protein 1 2vn8 » Reticulon-4-interacting protein 1
4.0 ± 0.0 Å
spacer 2wsi » FAD synthase
3.3 ± 1.7 Å
2wsi » FAD synthase
lipid
lipid
  spacer   lipid
lipid
3nks » Protoporphyrinogen oxidase 3nks » Protoporphyrinogen oxidase
4.8 ± 1.0 Å
spacer 2lop » Transmembrane proteins 14A
28.8 ± 2.0 Å
2lop » Transmembrane proteins 14A
lipid
lipid
  spacer   lipid
lipid
2los » Transmembrane protein 14C 2los » Transmembrane protein 14C
26.8 ± 0.4 Å
spacer 4ayx » Mitochondrial ABC transporter ABCB10, conformation 3
30.0 ± 0.6 Å
4ayx » Mitochondrial ABC transporter ABCB10, conformation 3
lipid
lipid
  spacer   lipid
lipid
3vr8 » Succinate dehydrogenase (mitochondrial respiratory complex II) 3vr8 » Succinate dehydrogenase (mitochondrial respiratory complex II)
30.4 ± 1.2 Å
spacer 4f4s » F1F0 ATP synthase, F0 complex
38.4 ± 1.3 Å
4f4s » F1F0 ATP synthase, F0 complex
lipid
lipid
  spacer   lipid
lipid
4g6h » Rotenone-insensitive NADH-ubiquinone oxidoreductase, NDI1 4g6h » Rotenone-insensitive NADH-ubiquinone oxidoreductase, NDI1
4.8 ± 0.0 Å
spacer 4b2q » F1F0 ATP synthase, F0F1 complex, more complete model
38.4 ± 0.9 Å
4b2q » F1F0 ATP synthase, F0F1 complex, more complete model
lipid
lipid
  spacer   lipid
lipid
4dvq » Cytochrome P450 11B2, mitochondrial 4dvq » Cytochrome P450 11B2, mitochondrial
4.8 ± 0.6 Å
spacer 2fyu » Cytochrome bc1, mitochondrial, structure 2
29.8 ± 0.5 Å
2fyu » Cytochrome bc1, mitochondrial, structure 2
lipid
lipid
  spacer   lipid
lipid
1bcc » Cytochrome bc1, mitochondrial, bovine/chicken, structure 1 1bcc » Cytochrome bc1, mitochondrial, bovine/chicken, structure 1
29.8 ± 0.6 Å
spacer 3bcc » Cytochrome bc1, mitochondrial, bovine/chicken, structure 2
28.6 ± 1.0 Å
3bcc » Cytochrome bc1, mitochondrial, bovine/chicken, structure 2
lipid
lipid
  spacer   lipid
lipid
3zry » F1F0 ATP synthase, F0F1 complex, different conformation 3zry » F1F0 ATP synthase, F0F1 complex, different conformation
33.6 ± 1.9 Å
spacer 3zdq » Mitochondrial ABC transporter ABCB10, conformation 4
30.8 ± 0.5 Å
3zdq » Mitochondrial ABC transporter ABCB10, conformation 4
lipid
lipid
  spacer   lipid
lipid
2c3e » Mitochondrial ADP-ATP carrier, with carboxyatractyloside 2c3e » Mitochondrial ADP-ATP carrier, with carboxyatractyloside
30.0 ± 1.0 Å
spacer 4c9g » Mitochondrial ADP-ATP carrier, conformation 1
31.4 ± 1.5 Å
4c9g » Mitochondrial ADP-ATP carrier, conformation 1
lipid
lipid
  spacer   lipid
lipid
4c9q » Mitochondrial ADP-ATP carrier, conformation 2 4c9q » Mitochondrial ADP-ATP carrier, conformation 2
30.2 ± 1.1 Å
spacer 4c9h » Mitochondrial ADP-ATP carrier, dimer, conformation 1
30.4 ± 0.7 Å
4c9h » Mitochondrial ADP-ATP carrier, dimer, conformation 1
lipid
lipid
  spacer   lipid
lipid
4myc » Iron-sulfur clusters transporter ATM1 4myc » Iron-sulfur clusters transporter ATM1
30.8 ± 1.4 Å
spacer 4klr » Ferrochelatase, conformation 2 (with porphyrin bound)
1.3 ± 0.0 Å
4klr » Ferrochelatase, conformation 2 (with porphyrin bound)
lipid
lipid
  spacer   lipid
lipid
4cq8 » Dihydroorotate dehydrogenase, structure 2 4cq8 » Dihydroorotate dehydrogenase, structure 2
4.9 ± 0.4 Å
spacer 3cxh » Cytochrome bc1, mitochondrial, with cytochrome c iso-2
27.6 ± 1.1 Å
3cxh » Cytochrome bc1, mitochondrial, with cytochrome c iso-2
lipid
lipid
  spacer   lipid
lipid
1ezv » Cytochrome bc1, mitochondrial 1ezv » Cytochrome bc1, mitochondrial
27.5 ± 0.6 Å
spacer   lipid
lipid
corner Mitochondrial inner membrane corner
Membrane Lipid Composition
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24. Membrane lipids: where they are and how they behave.