PDB ID or protein name

Membrane Protein Lipid Composition Atlas

1. Archaebacterial membrane (87 proteins)
2. Bacterial Gram-negative inner membrane (451 proteins)
3. Bacterial Gram-negative outer membrane (224 proteins)
4. Bacterial Gram-positive outer membrane (10 proteins)
5. Bacterial Gram-positive plasma membrane (142 proteins)
6. Chloroplast inner membrane (2 proteins)
7. Chloroplast outer membrane (2 proteins)
8. Cytoplasmic granule membrane (1 protein)
9. Endoplasmic reticulum membrane (203 proteins)
10. Endosome membrane (54 proteins)
11. Eukaryotic plasma membrane (800 proteins)
12. Golgi membrane (32 proteins)
13. Lysosome membrane (23 proteins)
14. Mitochondrial inner membrane (73 proteins)
15. Mitochondrial outer membrane (30 proteins)
16. Nuclear inner membrane (4 proteins)
17. Nuclear outer membrane (6 proteins)
18. Peroxisome membrane (11 proteins)
19. Secreted (958 proteins)
20. Thylakoid membrane (39 proteins)
21. Undefined (116 proteins)
22. Vacuole membrane (27 proteins)
23. Vesicle membrane (21 proteins)
24. Viral membrane (88 proteins)

Lipid Composition in Mitochondrial outer membrane

Cell/Species PC % PE % PI % PS % PA % CL % Sph % Ch % CB % SL % PI+PS % PI+LPE % LPC % PG %
Budding Yeast
Saccharomyces cerevisiae
45.6 32.6 10.2 1.2 4.4 5.9 - - - - - - - -

Mitochondrial outer membrane

corner lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid corner
lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid
1g5m » Apoptosis regulator Bcl-2 1g5m » Apoptosis regulator Bcl-2
4.2 ± 1.4 Å
spacer 1s3e » Monoamine oxidase B, monomer
7.3 ± 0.6 Å
1s3e » Monoamine oxidase B, monomer
lipid
lipid
  spacer   lipid
lipid
1o5w » Monoamine oxidase A 1o5w » Monoamine oxidase A
31.4 ± 3.4 Å
spacer 1nzn » Mitochondria fission 1 protein, crystal structure
6.1 ± 1.4 Å
1nzn » Mitochondria fission 1 protein, crystal structure
lipid
lipid
  spacer   lipid
lipid
2xfn » Monoamine oxidase B, dimer 2xfn » Monoamine oxidase B, dimer
30.0 ± 3.2 Å
spacer 2ka2 » BNip3 transmembrane domain homodimer, structure 1
30.8 ± 1.8 Å
2ka2 » BNip3 transmembrane domain homodimer, structure 1
lipid
lipid
  spacer   lipid
lipid
1zza » Stannin 1zza » Stannin
30.0 ± 2.0 Å
spacer 2l5b » Activator of apoptosis harakiri, transmembrane helix
29.8 ± 0.9 Å
2l5b » Activator of apoptosis harakiri, transmembrane helix
lipid
lipid
  spacer   lipid
lipid
2z5x » Monoamine oxidase A 2z5x » Monoamine oxidase A
31.0 ± 2.1 Å
spacer 2k4t » VDAC-1 channel, structure 2 (NMR)
22.0 ± 1.5 Å
2k4t » VDAC-1 channel, structure 2 (NMR)
lipid
lipid
  spacer   lipid
lipid
2jk4 » VDAC-1 channel, structure 1 2jk4 » VDAC-1 channel, structure 1
23.4 ± 2.3 Å
spacer 3emn » VDAC-1 channel
23.4 ± 1.1 Å
3emn » VDAC-1 channel
lipid
lipid
  spacer   lipid
lipid
2j5d » BNip3 transmembrane domain homodimer, structure 3 2j5d » BNip3 transmembrane domain homodimer, structure 3
30.8 ± 2.5 Å
spacer 2ka1 » BNip3 transmembrane domain homodimer, structure 2
34.4 ± 1.8 Å
2ka1 » BNip3 transmembrane domain homodimer, structure 2
lipid
lipid
  spacer   lipid
lipid
3p0l » Steroidogenic acute regulatory protein, mitochondrial 3p0l » Steroidogenic acute regulatory protein, mitochondrial
3.0 ± 1.3 Å
spacer 2l58 » Activator of apoptosis harakiri, cytosolic helix
2.4 ± 4.0 Å
2l58 » Activator of apoptosis harakiri, cytosolic helix
lipid
lipid
  spacer   lipid
lipid
2le3 » Carnitine O-palmitoyltransferase 1, liver isoform, N-terminal domain 2le3 » Carnitine O-palmitoyltransferase 1, liver isoform, N-terminal domain
3.9 ± 3.7 Å
spacer 1om2 » Mitochondrial import receptor subunit TOM20, 51-145, with presequence peptide
2.9 ± 2.7 Å
1om2 » Mitochondrial import receptor subunit TOM20, 51-145,  with presequence peptide
lipid
lipid
  spacer   lipid
lipid
3awr » Mitochondrial import receptor subunit TOM20, 59-126, with presequence peptide 3awr » Mitochondrial import receptor subunit TOM20, 59-126, with presequence peptide
5.0 ± 2.6 Å
spacer 4a1u » Bcl-2-like protein 1, complex with alpha-beta-foldamer
5.8 ± 0.3 Å
4a1u » Bcl-2-like protein 1, complex with alpha-beta-foldamer
lipid
lipid
  spacer   lipid
lipid
2m76 » Regulatory domain of brain carnitine palmitoyltransferase 2m76 » Regulatory domain of brain carnitine palmitoyltransferase
6.7 ± 1.0 Å
spacer 2m5i » BH3-interacting domain death agonist
6.4 ± 1.5 Å
2m5i » BH3-interacting domain death agonist
lipid
lipid
  spacer   lipid
lipid
4bum » VDAC-2 channel 4bum » VDAC-2 channel
23.4 ± 0.9 Å
spacer 2mgy » Mitochondrial translocator protein, TSPO, model 1
28.6 ± 1.6 Å
2mgy » Mitochondrial translocator protein, TSPO, model 1
lipid
lipid
  spacer   lipid
lipid
2n02 » Mitochondrial translocator protein, TSPO, model 2 2n02 » Mitochondrial translocator protein, TSPO, model 2
28.4 ± 1.6 Å
spacer 1o0l » Bcl-2-like protein 2
1.7 ± 2.3 Å
1o0l » Bcl-2-like protein 2
lipid
lipid
  spacer   lipid
lipid
1y8m » Mitochondria fission 1 protein 1y8m » Mitochondria fission 1 protein
5.2 ± 0.6 Å
spacer 1pc2 » Mitochondria fission 1 protein, NMR
8.5 ± 2.5 Å
1pc2 » Mitochondria fission 1 protein, NMR
lipid
lipid
  spacer   lipid
lipid
1f16 » Apoptosis regulator BAX 1f16 » Apoptosis regulator BAX
4.3 ± 0.8 Å
spacer 5jdp » VDAC-1 channel, structure 3 (NMR)
22.4 ± 1.0 Å
5jdp » VDAC-1 channel, structure 3 (NMR)
corner Mitochondrial outer membrane corner
Membrane Lipid Composition
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24. Membrane lipids: where they are and how they behave.