PDB ID or protein name

Membrane Protein Lipid Composition Atlas

1. Archaebacterial membrane (87 proteins)
2. Bacterial Gram-negative inner membrane (465 proteins)
3. Bacterial Gram-negative outer membrane (224 proteins)
4. Bacterial Gram-positive outer membrane (10 proteins)
5. Bacterial Gram-positive plasma membrane (143 proteins)
6. Chloroplast inner membrane (2 proteins)
7. Chloroplast outer membrane (2 proteins)
8. Cytoplasmic granule membrane (1 protein)
9. Endoplasmic reticulum membrane (206 proteins)
10. Endosome membrane (55 proteins)
11. Eukaryotic plasma membrane (820 proteins)
12. Golgi membrane (32 proteins)
13. Lysosome membrane (23 proteins)
14. Mitochondrial inner membrane (73 proteins)
15. Mitochondrial outer membrane (30 proteins)
16. Nuclear inner membrane (4 proteins)
17. Nuclear outer membrane (6 proteins)
18. Peroxisome membrane (11 proteins)
19. Secreted (963 proteins)
20. Thylakoid membrane (39 proteins)
21. Undefined (117 proteins)
22. Vacuole membrane (28 proteins)
23. Vesicle membrane (21 proteins)
24. Viral membrane (88 proteins)

Lipid Composition in Viral membrane

Cell/Species PC % PE % PI % PS % PA % CL % Sph % Ch % CB % SL % PI+PS % PI+LPE % LPC % PG %
HIV-1
Human immunodeficiency virus type 1
16.0 35.2 - 15.5 - - 33.1 - - - - - - -

Viral membrane

corner lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid corner
lipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipidlipid
3lbw » M2 proton channel of Influenza A, closed state 3lbw » M2 proton channel of Influenza A, closed state
31.1 ± 1.7 Å
spacer 1aa7 » Influenza virus matrix protein M1, structure 1
2.6 ± 0.8 Å
1aa7 » Influenza virus matrix protein M1, structure 1
lipid
lipid
  spacer   lipid
lipid
1svf » Paramyxovirus sv5 fusion protein core 1svf » Paramyxovirus sv5 fusion protein core
8.4 ± 0.9 Å
spacer 1n7v » Adsorption protein p2
8.7 ± 0.4 Å
1n7v » Adsorption protein p2
lipid
lipid
  spacer   lipid
lipid
1ok8 » Envelope glycoprotein, Dengue virus type 2, structure 1 1ok8 » Envelope glycoprotein, Dengue virus type 2, structure 1
5.2 ± 0.9 Å
spacer 1rer » E1 envelope glycoprotein
2.6 ± 2.0 Å
1rer » E1 envelope glycoprotein
lipid
lipid
  spacer   lipid
lipid
1urz » Envelope glycoprotein 1urz » Envelope glycoprotein
5.9 ± 0.9 Å
spacer 4qkm » M2 proton channel of Influenza A, open state, ligand-free
28.4 ± 1.7 Å
4qkm » M2 proton channel of Influenza A, open state, ligand-free
lipid
lipid
  spacer   lipid
lipid
3c9j » M2 proton channel of Influenza A, open state, complex with amantadine 3c9j » M2 proton channel of Influenza A, open state, complex with amantadine
29.4 ± 1.4 Å
spacer 2rlf » M2 proton channel of Influenza A, closed state, NMR
34.3 ± 2.0 Å
2rlf » M2 proton channel of Influenza A, closed state, NMR
lipid
lipid
  spacer   lipid
lipid
2kwx » M2 proton channel of Influenza A, closed state, V27A mutant 2kwx » M2 proton channel of Influenza A, closed state, V27A mutant
33.4 ± 1.9 Å
spacer 2kix » M2 proton channel of Influenza B
31.8 ± 1.2 Å
2kix » M2 proton channel of Influenza B
lipid
lipid
  spacer   lipid
lipid
2kqt » M2 proton channel of Influenza A, complex with amantadine 2kqt » M2 proton channel of Influenza A, complex with amantadine
30.2 ± 1.3 Å
spacer 2x7r » Envelope glycoprotein gp41
5.5 ± 1.1 Å
2x7r » Envelope glycoprotein gp41
lipid
lipid
  spacer   lipid
lipid
1emz » Envelope glycoprotein E1, heterodimerization peptide (350-370) 1emz » Envelope glycoprotein E1, heterodimerization peptide (350-370)
6.2 ± 0.2 Å
spacer 2cps » Capsid protein G8P, monomer
30.8 ± 3.1 Å
2cps » Capsid protein G8P, monomer
lipid
lipid
  spacer   lipid
lipid
1ibn » Hemagglutinin, fusion peptide 346-365, wild type 1ibn » Hemagglutinin, fusion peptide 346-365, wild type
9.1 ± 1.2 Å
spacer 1xop » Hemagglutinin, fusion peptide 346-365, G1S
6.3 ± 0.5 Å
1xop » Hemagglutinin, fusion peptide 346-365, G1S
lipid
lipid
  spacer   lipid
lipid
2ljb » M2 proton channel, influenza A and B hydrid 2ljb » M2 proton channel, influenza A and B hydrid
31.6 ± 1.6 Å
spacer 2ljc » M2 proton channel, influenza A and B hydrid, complex with rimantadine
30.6 ± 1.8 Å
2ljc » M2 proton channel, influenza A and B hydrid, complex with rimantadine
lipid
lipid
  spacer   lipid
lipid
2rlj » Fusion peptide (524-539) of ebolavirus glycoprotein GP2 2rlj » Fusion peptide (524-539) of ebolavirus glycoprotein GP2
5.8 ± 1.8 Å
spacer 2l4g » Hemagglutinin, fusion peptide 346-365, G13A
11.1 ± 0.4 Å
2l4g » Hemagglutinin, fusion peptide 346-365, G13A
lipid
lipid
  spacer   lipid
lipid
2jrd » Hemagglutinin, peptide 330-349, F9A 2jrd » Hemagglutinin, peptide 330-349, F9A
8.1 ± 4.0 Å
spacer 3g7t » Envelope glycoprotein, Dengue virus type 1
5.9 ± 0.9 Å
3g7t » Envelope glycoprotein, Dengue virus type 1
lipid
lipid
  spacer   lipid
lipid
3nw8 » Envelope glycoprotein B 3nw8 » Envelope glycoprotein B
4.6 ± 0.0 Å
spacer 5i2m » Glycoprotein G, structure 1
6.3 ± 4.2 Å
5i2m » Glycoprotein G, structure 1
lipid
lipid
  spacer   lipid
lipid
3j0c » E1/E2 envelope glycoprotein complex 3j0c » E1/E2 envelope glycoprotein complex
31.2 ± 1.7 Å
spacer 3duz » Major envelope glycoprotein
3.2 ± 0.4 Å
3duz » Major envelope glycoprotein
lipid
lipid
  spacer   lipid
lipid
1lg7 » Matrix protein, Indiana virus 1lg7 » Matrix protein, Indiana virus
2.7 ± 0.4 Å
spacer 2w2r » Matrix protein, New Jersey virus
4.1 ± 0.1 Å
2w2r » Matrix protein, New Jersey virus
lipid
lipid
  spacer   lipid
lipid
4owr » Matrix protein, Indiana virus, complex with mRNA export factor 4owr » Matrix protein, Indiana virus, complex with mRNA export factor
2.1 ± 0.8 Å
spacer 2yew » E1/E2 envelope glycoprotein complex
30.0 ± 0.8 Å
2yew » E1/E2 envelope glycoprotein complex
lipid
lipid
  spacer   lipid
lipid
2lif » Viral core-E1 signal peptide 2lif » Viral core-E1 signal peptide
29.6 ± 5.0 Å
spacer 1a6s » Matrix protein p19
3.1 ± 2.7 Å
1a6s » Matrix protein p19
lipid
lipid
  spacer   lipid
lipid
2lpy » Matrix protein p10, myristoylated, structure 1 2lpy » Matrix protein p10, myristoylated, structure 1
3.2 ± 0.5 Å
spacer 2f76 » Matrix protein p10
3.9 ± 1.2 Å
2f76 » Matrix protein p10
lipid
lipid
  spacer   lipid
lipid
3j2p » Capsid envelop protein complex, Dengue 3j2p » Capsid envelop protein complex, Dengue
22.8 ± 0.4 Å
spacer 2ly0 » M2 proton channel of Influenza A, closed state, S31N, with drug
34.0 ± 1.6 Å
2ly0 » M2 proton channel of Influenza A, closed state, S31N, with drug
lipid
lipid
  spacer   lipid
lipid
2lp7 »  gp41-M-MAT, a membrane associated MPER trimer 2lp7 » gp41-M-MAT, a membrane associated MPER trimer
26.8 ± 0.9 Å
spacer 2kxa » Hemagglutinin, fusion peptide 346-365, H1 subtype
10.3 ± 1.9 Å
2kxa » Hemagglutinin, fusion peptide 346-365, H1 subtype
lipid
lipid
  spacer   lipid
lipid
3j2w » E1/E2 envelope glycoprotein complex 3j2w » E1/E2 envelope glycoprotein complex
30.8 ± 0.9 Å
spacer 2lvg » Nonstructural protein 4b, segment 1716-1755
6.4 ± 0.7 Å
2lvg » Nonstructural protein 4b, segment 1716-1755
lipid
lipid
  spacer   lipid
lipid
2m8o » Membrane proximal external helix of HIV-1 gp41 (656-683) 2m8o » Membrane proximal external helix of HIV-1 gp41 (656-683)
6.0 ± 5.2 Å
spacer 2mm4 » Envelope small membrane protein
29.6 ± 4.1 Å
2mm4 » Envelope small membrane protein
lipid
lipid
  spacer   lipid
lipid
1es6 » Matrix protein VP40 1es6 » Matrix protein VP40
2.1 ± 0.5 Å
spacer 4pus » Influenza virus matrix protein M1, structure 2
2.3 ± 1.6 Å
4pus » Influenza virus matrix protein M1, structure 2
lipid
lipid
  spacer   lipid
lipid
2hg0 » Envelope glycoprotein, West Nile virus, structure 1 2hg0 » Envelope glycoprotein, West Nile virus, structure 1
4.8 ± 2.6 Å
spacer 3n41 » E1 envelope glycoprotein
2.5 ± 2.9 Å
3n41 » E1 envelope glycoprotein
lipid
lipid
  spacer   lipid
lipid
2lcy » Fusion peptide (507-560) of ebolavirus glycoprotein GP2, wild type 2lcy » Fusion peptide (507-560) of ebolavirus glycoprotein GP2, wild type
3.5 ± 2.2 Å
spacer 2mb1 » Fusion peptide (507-560) of ebolavirus glycoprotein GP2, mutant 1
3.8 ± 1.8 Å
2mb1 » Fusion peptide (507-560) of ebolavirus glycoprotein GP2, mutant 1
lipid
lipid
  spacer   lipid
lipid
2m5f » Fusion peptide (507-560) of ebolavirus glycoprotein GP2, mutant 2 2m5f » Fusion peptide (507-560) of ebolavirus glycoprotein GP2, mutant 2
5.7 ± 1.7 Å
spacer 2muv » M2 proton channel of Influenza A, drug-bound
32.4 ± 1.1 Å
2muv » M2 proton channel of Influenza A, drug-bound
lipid
lipid
  spacer   lipid
lipid
2mjz » Capsid protein G8P 2mjz » Capsid protein G8P
30.8 ± 0.3 Å
spacer 2n70 » M2 proton channel of Influenza A, S31N, NMR structure
29.8 ± 1.7 Å
2n70 » M2 proton channel of Influenza A, S31N, NMR structure
lipid
lipid
  spacer   lipid
lipid
4rwb » M2 proton channel of Influenza A, monomer 4rwb » M2 proton channel of Influenza A, monomer
31.6 ± 4.5 Å
spacer 2mxi » Matrix protein p10, myristoylated, structure 2
3.8 ± 0.7 Å
2mxi » Matrix protein p10, myristoylated, structure 2
lipid
lipid
  spacer   lipid
lipid
2nb7 » Small hydrophobic protein, peptide 1-14 2nb7 » Small hydrophobic protein, peptide 1-14
4.1 ± 0.9 Å
spacer 5c02 » M2 proton channel of Influenza A, S31N, crystal structure
28.6 ± 1.9 Å
5c02 » M2 proton channel of Influenza A, S31N, crystal structure
lipid
lipid
  spacer   lipid
lipid
5jyn » Transmembrane domain of HIV-1 gp41 (677-716), trimer 5jyn » Transmembrane domain of HIV-1 gp41 (677-716), trimer
36.0 ± 1.6 Å
spacer 5j81 » Glycoprotein C, structure 1
6.0 ± 0.3 Å
5j81 » Glycoprotein C, structure 1
lipid
lipid
  spacer   lipid
lipid
5j9h » Glycoprotein C, structure 2 5j9h » Glycoprotein C, structure 2
4.8 ± 0.3 Å
spacer 3uaj » Envelope glycoprotein, Dengue virus type 4
5.6 ± 2.6 Å
3uaj » Envelope glycoprotein, Dengue virus type 4
lipid
lipid
  spacer   lipid
lipid
1k4r » Envelope glycoprotein, chimeric 1k4r » Envelope glycoprotein, chimeric
6.6 ± 2.4 Å
spacer 1uzg » Envelope glycoprotein, Dengue virus type 3
5.7 ± 2.7 Å
1uzg » Envelope glycoprotein, Dengue virus type 3
lipid
lipid
  spacer   lipid
lipid
2i69 » Envelope glycoprotein, West Nile virus, structure 2 2i69 » Envelope glycoprotein, West Nile virus, structure 2
6.7 ± 2.8 Å
spacer 3c6e » Envelope glycoprotein, Dengue virus type 2, structure 2
2.9 ± 2.7 Å
3c6e » Envelope glycoprotein, Dengue virus type 2, structure 2
lipid
lipid
  spacer   lipid
lipid
3i50 » Envelope glycoprotein, West Nile virus, structure 3 3i50 » Envelope glycoprotein, West Nile virus, structure 3
6.3 ± 2.8 Å
spacer 3iyw » Envelope glycoprotein, West Nile virus, structure 4
6.6 ± 2.9 Å
3iyw » Envelope glycoprotein, West Nile virus, structure 4
lipid
lipid
  spacer   lipid
lipid
3p54 » Envelope glycoprotein 3p54 » Envelope glycoprotein
6.1 ± 2.2 Å
spacer 4fg0 » Envelope glycoprotein
6.5 ± 0.6 Å
4fg0 » Envelope glycoprotein
lipid
lipid
  spacer   lipid
lipid
4ut6 » Envelope glycoprotein, Dengue virus type 2, structure 3 4ut6 » Envelope glycoprotein, Dengue virus type 2, structure 3
6.2 ± 3.0 Å
spacer 4ut9 » Envelope glycoprotein, Dengue virus type 2, structure 4
5.5 ± 2.8 Å
4ut9 » Envelope glycoprotein, Dengue virus type 2, structure 4
lipid
lipid
  spacer   lipid
lipid
4utc » Envelope glycoprotein, Dengue virus type 2, structure 5 4utc » Envelope glycoprotein, Dengue virus type 2, structure 5
6.3 ± 2.4 Å
spacer 5i2s » Glycoprotein G, structure 2
5.3 ± 0.4 Å
5i2s » Glycoprotein G, structure 2
lipid
lipid
  spacer   lipid
lipid
2b4h » Outer capsid protein VP4, dimer 2b4h » Outer capsid protein VP4, dimer
2.2 ± 0.2 Å
spacer 2b4i » Outer capsid protein VP4, trimer
2.9 ± 0.3 Å
2b4i » Outer capsid protein VP4, trimer
lipid
lipid
  spacer   lipid
lipid
4u2x » Membrane-associated protein VP24, with karyopherin 4u2x » Membrane-associated protein VP24, with karyopherin
4.5 ± 2.1 Å
spacer 5ire » Capsid envelop protein complex, Zika, structure 1
25.8 ± 0.6 Å
5ire » Capsid envelop protein complex, Zika, structure 1
lipid
lipid
  spacer   lipid
lipid
5iz7 » Capsid envelop protein complex, Zika, structure 2 5iz7 » Capsid envelop protein complex, Zika, structure 2
25.8 ± 0.0 Å
spacer 5lcv » Envelope glycoprotein, Zika virus, structure 1
6.0 ± 2.6 Å
5lcv » Envelope glycoprotein, Zika virus, structure 1
lipid
lipid
  spacer   lipid
lipid
5jhl » Envelope glycoprotein, Zika virus, structure 2 5jhl » Envelope glycoprotein, Zika virus, structure 2
5.9 ± 2.8 Å
spacer 5jhm » Envelope glycoprotein, Zika virus, structure 3
6.6 ± 2.4 Å
5jhm » Envelope glycoprotein, Zika virus, structure 3
lipid
lipid
  spacer   lipid
lipid
5lbv » Envelope glycoprotein, Zika virus, structure 4 5lbv » Envelope glycoprotein, Zika virus, structure 4
5.7 ± 2.9 Å
spacer 5lbs » Envelope glycoprotein, Zika virus, structure 5
2.3 ± 2.5 Å
5lbs » Envelope glycoprotein, Zika virus, structure 5
lipid
lipid
  spacer   lipid
lipid
5gzn » Envelope glycoprotein, Zika virus, structure 6 5gzn » Envelope glycoprotein, Zika virus, structure 6
5.1 ± 2.6 Å
spacer 2ncs » Membrane proximal peptide of gp41 (95-121)
20.8 ± 2.0 Å
2ncs » Membrane proximal peptide of gp41 (95-121)
lipid
lipid
  spacer   lipid
lipid
2nb8 » Small hydrophobic protein, peptide 39-49 2nb8 » Small hydrophobic protein, peptide 39-49
8.5 ± 1.2 Å
spacer 5jbl » T4 capsid assembly protease, gp21
3.6 ± 0.2 Å
5jbl » T4 capsid assembly protease, gp21
corner Viral membrane corner
Membrane Lipid Composition
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24. Membrane lipids: where they are and how they behave.