PDB ID or protein name

Transmembrane classes

1.1. Alpha-helical transmembrane (54 superfamilies)
1.2. Beta-barrel transmembrane (19 superfamilies)

Transmembrane (268 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
1.1.01.01. Sensory rhodopsin II, monomer 1h68 Natronomonas pharaonis Archaebac. 1 7 31.6 ± 2.5 12 ± 5 -76.2
1.1.01.01. Archaerhodopsin-2, trimeric 2ei4 Halobacterium sp. Archaebac. 3 21 30.1 ± 0.9 0 ± 1 -158.4
1.1.01.01. Bacteriorhodopsin, monomer 1py6 Halobacterium salinarum Archaebac. 1 7 31.0 ± 2.5 13 ± 6 -75.9
1.1.01.01. Archaerhodopsin-2 1vgo Halobacterium sp. Archaebac. 1 7 30.8 ± 1.5 9 ± 4 -81.8
1.1.01.01. Bacteriorhodopsin, trimer 1m0l Halobacterium salinarum Archaebac. 3 21 30.0 ± 1.1 0 ± 1 -149.5
1.1.01.01. Sensory rhodopsin II 1h2s Natronomonas pharaonis Archaebac. 4 18 29.5 ± 1.1 0 ± 2 -160.0
1.1.01.01. Sensory Rhodopsin 1xio Anabaena sp. Bact. gram-neg inner 1 7 31.2 ± 2.8 8 ± 6 -71.7
1.1.01.01. Xanthorhodopsin 3ddl Salinibacter ruber Bact. gram-neg inner 1 7 26.0 ± 1.5 14 ± 3 -68.2
1.1.01.01. Halorhodopsin 1e12 Halobacterium salinarum Archaebac. 3 21 30.9 ± 1.8 0 ± 1 -151.6
1.1.01.01. Archaerhodopsin-1 1uaz Halobacterium sp. Archaebac. 1 7 31.7 ± 2.2 6 ± 4 -73.9
1.1.01.02. Mu-opioid receptor model (inactive state) with antagonist 2iql Rattus norvegicus Eukaryo. plasma 1 7 35.0 ± 1.0 9 ± 3 -97.7
1.1.01.02. Rhodopsin 1gzm Bos taurus Eukaryo. plasma 1 7 32.4 ± 1.7 8 ± 3 -91.3
1.1.01.02. Cholecystokinin A receptor fragment 1d6g Homo sapiens Eukaryo. plasma 2 0 8.0 ± 0.8 89 ± 7 -16.1
1.1.01.02. Opsin, complex with C-terminal peptide of Galpha subunit of transducin 3dqb Bos taurus Eukaryo. plasma 1 7 31.5 ± 1.4 6 ± 3 -86.3
1.1.01.02. TM1-TM2 fragment of fungal STE2 receptor 2k9p Saccharomyces cerevisiae Eukaryo. plasma 1 2 31.5 ± 2.0 5 ± 7 -25.7
1.1.01.02. Opsin, retinal-free state 3cap Bos taurus Eukaryo. plasma 1 7 31.4 ± 1.3 6 ± 4 -86.0
1.1.01.02. Beta2-adrenergic receptor 2rh1 Homo sapiens Eukaryo. plasma 1 7 31.4 ± 1.3 8 ± 3 -84.3
1.1.01.02. Rhodopsin, a photobleached state 2i37 Bos taurus Eukaryo. plasma 1 7 31.9 ± 1.4 5 ± 4 -88.6
1.1.01.02. A2A adenosine receptor bound to antagonist ZM241385 3eml Homo sapiens Eukaryo. plasma 1 7 33.2 ± 2.2 8 ± 4 -85.1
1.1.01.02. Rhodopsin, a dimer 2i36 Bos taurus Eukaryo. plasma 2 14 30.5 ± 1.4 0 ± 1 -161.5
1.1.01.02. Melanocortin-4 receptor model (active state) with agonist NDP-MSH 2iqr Homo sapiens Eukaryo. plasma 1 7 34.5 ± 1.5 18 ± 3 -80.2
1.1.01.02. Squid rhodopsin dimer 2z73 Todarodes pacificus Eukaryo. plasma 2 14 33.5 ± 1.1 0 ± 2 -167.5
1.1.01.02. Melanocortin-4 receptor model (inactive state) with antagonist AGRP 2iqv Homo sapiens Eukaryo. plasma 1 7 33.5 ± 1.5 19 ± 3 -75.3
1.1.01.02. Mu-opioid receptor model in active state with agonist 2iqo Rattus norvegicus Eukaryo. plasma 1 7 35.3 ± 1.6 1 ± 4 -95.7
1.1.01.02. Beta1-adrenergic receptor 2vt4 Meleagris gallopavo Eukaryo. plasma 1 7 32.7 ± 1.5 6 ± 4 -95.7
1.1.02.01. Photosynthetic reaction center 1eys Thermochromatium tepidum Bact. gram-neg inner 3 11 30.0 ± 1.5 4 ± 1 -133.8
1.1.02.01. Photosynthetic reaction center 1rzh Rhodobacter sphaeroides Bact. gram-neg inner 3 11 30.0 ± 1.2 5 ± 1 -141.0
1.1.02.01. Photosynthetic reaction center 1dxr Rhodopseudomonas viridis Bact. gram-neg inner 3 11 30.5 ± 1.8 6 ± 1 -138.5
1.1.02.02. Photosystem I 1jb0 Thermosynechococcus elongatus Thylakoid 9 32 32.0 ± 0.8 1 ± 1 -345.1
1.1.02.02. Photosystem I 2o01 Pisum sativum Thylakoid 16 43 27.5 ± 0.5 3 ± 1 -791.8
1.1.02.03. Photosystem II 3bz1 Thermosynechococcus elongatus Thylakoid 34 72 31.2 ± 0.6 0 ± 1 -513.1
1.1.03.01. Light-harvesting complex LH2 1nkz Rhodopseudomonas acidophila Bact. gram-neg inner 18 18 27.8 ± 0.8 0 ± 0 -246.8
1.1.03.01. Light-harvesting complex LH3 1ijd Rhodopseudomonas acidophila Bact. gram-neg inner 18 18 26.2 ± 0.8 0 ± 0 -205.4
1.1.03.01. Light-harvesting complex 1lgh Rhodospirillum molischianum Bact. gram-neg inner 16 16 28.7 ± 0.9 0 ± 1 -187.3
1.1.03.02. Light-Harvesting Complex II 1rwt Spinacia oleracea Thylakoid 3 9 28.0 ± 1.3 0 ± 1 -198.2
1.1.03.02. Light-Harvesting Complex II 2bhw Pisum sativum Thylakoid 3 9 28.0 ± 1.0 0 ± 1 -160.4
1.1.04.01. Cytochrome bc1, mitochondrial 1bcc Gallus gallus Mitochon. inner 10 24 26.1 ± 1.0 0 ± 1 -203.0
1.1.04.01. Cytochrome b6f 1q90 Chlamydomonas reinhardtii Thylakoid 16 26 32.5 ± 0.9 0 ± 1 -261.7
1.1.04.01. Cytochrome bc1, mitochondrial 1l0l Bos taurus Mitochon. inner 12 26 26.8 ± 0.6 0 ± 0 -241.6
1.1.04.01. Cytochrome bc1, mitochondrial 1kb9 Saccharomyces cerevisiae Mitochon. inner 10 24 26.0 ± 0.8 0 ± 0 -219.4
1.1.04.01. Cytochrome bc1, bacterial 2fyn Rhodobacter sphaeroides Bact. gram-neg inner 6 20 27.7 ± 1.2 1 ± 1 -195.3
1.1.04.01. Cytochrome b6f 2e74 Mastigocladus laminosus Thylakoid 16 26 31.5 ± 0.8 0 ± 1 -291.2
1.1.04.01. Cytochrome bc1, mitochondrial 1pp9 Bos taurus Mitochon. inner 10 26 26.1 ± 0.5 0 ± 5 -208.6
1.1.04.01. Cytochrome b6f 2zt9 Nostoc sp. Thylakoid 16 26 31.0 ± 1.0 0 ± 1 269.6
1.1.04.02. Formate dehydrogenase 1kqf Escherichia coli Bact. gram-neg inner 6 15 32.7 ± 1.1 0 ± 2 -174.0
1.1.04.03. Respiratory Nitrate Reductase 1q16 Escherichia coli Bact. gram-neg inner 2 10 29.5 ± 1.0 0 ± 2 -150.6
1.1.04.04. Fumarate reductase 2bs3 Wolinella succinogenes Bact. gram-neg inner 2 10 30.0 ± 1.0 0 ± 1 -131.9
1.1.04.04. Fumarate reductase 2bs2 Wolinella succinogenes Bact. gram-neg inner 2 10 29.7 ± 0.8 0 ± 1 -128.8
1.1.04.05. Fumarate reductase 1kf6 Escherichia coli Bact. gram-neg inner 2 6 30.0 ± 1.8 10 ± 5 -84.5
1.1.04.05. Succinate dehydrogenase 1nek Escherichia coli Bact. gram-neg inner 6 18 32.0 ± 1.0 0 ± 1 -203.1
1.1.04.05. Succinate dehydrogenase (mitochondrial respiratory complex II) 1zoy Sus scrofa Mitochon. inner 2 6 28.0 ± 2.2 12 ± 3 -75.1
1.1.04.05. Succinate dehydrogenase (mitochondrial respiratory complex II) 1yq3 Gallus gallus Mitochon. inner 2 6 33.5 ± 1.2 6 ± 2 -72.0
1.1.05.01. Mitochondrial cytochrome c oxidase 1v55 Bos taurus Mitochon. inner 20 56 25.4 ± 1.8 0 ± 2 -245.1
1.1.05.01. Bacterial cytochrome c oxidase 1m56 Rhodobacter sphaeroides Bact. gram-neg inner 4 22 30.5 ± 0.7 2 ± 0 -201.7
1.1.05.01. Bacterial cytochrome c oxidase 1qle Paracoccus denitrificans Bact. gram-neg inner 4 22 31.2 ± 1.5 3 ± 1 -208.8
1.1.05.01. Bacterial cytochrome c oxidase 1ehk Thermus thermophilus Bact. gram-neg inner 3 15 30.4 ± 1.3 5 ± 2 -135.6
1.1.05.01. Ubiquinol Oxidase 1fft Escherichia coli Bact. gram-neg inner 3 19 29.0 ± 1.2 3 ± 1 -122.9
1.1.05.01. Bacterial cytochrome c oxidase 1ar1 Paracoccus denitrificans Bact. gram-neg inner 2 14 33.5 ± 2.0 9 ± 2 -129.0
1.1.06.01. F1F0 ATP synthase subunit c 1a91 Escherichia coli Bact. gram-neg inner 1 2 36.5 ± 3.2 22 ± 8 -41.4
1.1.06.01. ATP synthase of chloroplast 2w5j Spinacia oleracea Thylakoid 14 28 35.5 ± 1.4 0 ± 1 -148.1
1.1.06.01. F1F0 ATP synthase 1c17 Escherichia coli Bact. gram-neg inner 13 28 35.9 ± 0.8 2 ± 0 -211.2
1.1.06.01. F1F0 ATP synthase 2wie Arthrospira platensis Thylakoid 15 30 31.4 ± 0.5 0 ± 1 -157.3
1.1.06.01. F-type Sodium ATPase 1yce Ilyobacter tartaricus Bact. gram-neg inner 11 22 37.0 ± 0.8 0 ± 1 -138.3
1.1.06.01. V-type Sodium ATPase 2bl2 Enterococcus hirae Bact. gram-neg inner 10 40 36.7 ± 0.8 0 ± 0 -242.5
1.1.06.01. F1F0 ATP synthase subunit c 1wu0 Bacillus ps3 Bact. gram-pos plas. 1 2 32.6 ± 2.3 39 ± 6 -35.6
1.1.07.01. Particulate Methane Monooxygenase 3chx Methylosinus trichosporium Bact. gram-neg inner 10 30 28.7 ± 1.0 0 ± 1 -214.0
1.1.07.01. Particulate Methane Monooxygenase 1yew Methylococcus capsulatus Bact. gram-neg inner 9 42 25.0 ± 0.9 0 ± 1 -199.2
1.1.08.01. Sodium-potassium pump, E2-Pi state 2zxe Squalus acanthias Eukaryo. plasma 3 13 30.1 ± 1.8 8 ± 2 -115.7
1.1.08.01. Calcium ATPase, E2 state (Ca-free) 2agv Oryctolagus cuniculus Endoplasm. reticulum 1 10 30.1 ± 1.8 18 ± 3 -81.8
1.1.08.01. Calcium ATPase, E1-2Ca state 1su4 Oryctolagus cuniculus Endoplasm. reticulum 1 10 29.0 ± 2.8 23 ± 4 -81.0
1.1.08.01. Calcium ATPase, E2-Pi state 1wpg Oryctolagus cuniculus Endoplasm. reticulum 1 10 30.0 ± 1.5 19 ± 2 -89.9
1.1.08.01. Sodium-potassium pump, E2-Pi state 3b8e Sus scrofa Eukaryo. plasma 3 12 30.0 ± 1.0 12 ± 2 -121.1
1.1.08.01. Calcium ATPase, E1-ATP state 1t5s Oryctolagus cuniculus Endoplasm. reticulum 1 10 27.0 ± 1.2 24 ± 1 -80.4
1.1.08.01. Plasma membrane proton pump, E1-ATP state 3b8c Arabidopsis thaliana Eukaryo. plasma 1 10 27.5 ± 1.8 11 ± 3 -69.4
1.1.08.01. Calcium ATPase, E1P-ADP state 1wpe Oryctolagus cuniculus Endoplasm. reticulum 1 10 30.5 ± 1.0 19 ± 1 -79.1
1.1.08.01. Calcium ATPase, E2-Pi state, alternative conformation 3b9b Oryctolagus cuniculus Endoplasm. reticulum 1 10 28.0 ± 1.5 15 ± 2 -80.4
1.1.09.01. ABC transporter permease HI1471 2nq2 Haemophilus influenzae Bact. gram-neg inner 2 20 31.5 ± 1.4 1 ± 3 -148.2
1.1.09.01. ABC-transporter BtuCD in complex with BtuF 2qi9 Escherichia coli Bact. gram-neg inner 2 22 27.3 ± 1.1 4 ± 2 -140.7
1.1.09.01. ABC transporter BtuCD 1l7v Escherichia coli Bact. gram-neg inner 2 22 29.1 ± 1.0 0 ± 2 -142.8
1.1.09.02. Lipid flippase MsbA 3b60 Salmonella typhimurium Bact. gram-neg inner 2 12 32.5 ± 0.9 0 ± 1 -111.8
1.1.09.02. Multidrug ABC transporter SAV1866, closed state 2hyd Staphylococcus aureus Bact. gram-pos plas. 2 12 34.5 ± 2.0 0 ± 2 -135.0
1.1.09.03. Molybdate transporter ModBC, open state 3d31 Methanosarcina acetivorans Archaebac. 2 12 29.3 ± 1.0 1 ± 2 -112.6
1.1.09.03. Molybdate transporter ModBC, open state 2onk Archaeoglobus fulgidus Archaebac. 2 12 35.0 ± 1.3 0 ± 2 -119.0
1.1.09.04. Maltose transporter MalFGK 2r6g Escherichia coli Bact. gram-neg inner 2 14 29.5 ± 2.0 2 ± 3 -121.9
1.1.09.05. Methionine importer MetNI 3dhw Escherichia coli Bact. gram-neg inner 2 10 23.5 ± 2.0 6 ± 5 -78.4
1.1.09.06. P-glycoprotein 3g5u Mus musculus Eukaryo. plasma 1 12 30.6 ± 1.2 3 ± 2 -120.9
1.1.12.01. Preprotein Translocase SecY 1rh5 Methanococcus jannaschii Archaebac. 3 12 28.5 ± 1.0 10 ± 1 -115.4
1.1.12.01. Preprotein Translocase SecY 3din Thermotoga maritima Bact. gram-neg inner 3 13 25.5 ± 1.5 12 ± 2 -82.1
1.1.12.01. Preprotein translocase SecY 2zjs Thermus thermophilus Bact. gram-neg inner 2 11 26.5 ± 1.0 10 ± 1 -108.4
1.1.13.01. Mitochondrial ADP/ATP carrier 1ym6 Bos taurus Mitochon. inner 2 7 28.4 ± 1.3 5 ± 3 -62.8
1.1.13.01. Mitochondrial ADP/ATP carrier 1okc Bos taurus Mitochon. inner 1 6 28.0 ± 1.8 5 ± 3 -52.4
1.1.13.03. Multidrug transporter EmrD 2gfp Escherichia coli Bact. gram-neg inner 1 12 31.8 ± 1.0 11 ± 2 -88.5
1.1.14.01. Glycerol-3-Phosphate Transporter 1pw4 Escherichia coli Bact. gram-neg inner 1 12 31.0 ± 1.4 3 ± 3 -107.8
1.1.14.02. Lactose permease, structure at neutral pH 2cfq Escherichia coli Bact. gram-neg inner 1 12 31.9 ± 1.2 5 ± 3 -113.4
1.1.14.02. Lactose Permease, structure at acidic pH 2cfp Escherichia coli Bact. gram-neg inner 1 12 31.4 ± 1.4 5 ± 3 -111.7
1.1.15.01. Multidrug exporter MexB 2v50 Pseudomonas aeruginosa Bact. gram-neg inner 3 36 27.5 ± 0.8 0 ± 1 -189.7
1.1.15.01. Multidrug efflux transporter AcrB 2gif Escherichia coli Bact. gram-neg inner 3 36 27.5 ± 0.8 2 ± 2 -212.8
1.1.15.01. Multidrug efflux transporter AcrB with an additional TM helix 2rdd Escherichia coli Bact. gram-neg inner 6 39 26.5 ± 0.8 0 ± 1 -239.0
1.1.16.01. Proton Glutamate Symport Protein 2nwl Pyrococcus horikoshii Archaebac. 3 39 26.8 ± 0.9 0 ± 1 -251.0
1.1.17.01. Sodium/proton antiporter 1 (NhaA) 1zcd Escherichia coli Bact. gram-neg inner 1 14 27.5 ± 1.0 4 ± 2 -100.1
1.1.18.01. Leucine transporter LeuT 2a65 Aquifex aeolicus Bact. gram-neg inner 2 28 27.0 ± 0.9 0 ± 1 -170.9
1.1.18.02. Nucleobase-cation symporter-1 2jln Mycobacterium liquefaciens Bact. gram-neg inner 1 12 27.9 ± 1.3 20 ± 1 -114.1
1.1.18.03. Sodium/sugar symporter vSGLT 3dh4 Vibrio parahaemolyticus Bact. gram-neg inner 2 30 27.0 ± 1.2 0 ± 1 -204.4
1.1.18.04. Sodium-betaine symporter BetP 2w8a Corinebacterium glutamicum Bact. gram-neg inner 3 39 27.9 ± 0.8 0 ± 1 -246.7
1.1.18.05. Arginine/agmatine antiporter (AdiC) 3h5m Escherichia coli Bact. gram-neg inner 2 26 34.0 ± 1.4 0 ± 1 -157.3
1.1.18.05. ApcT transporter 3gia Methanococcus jannaschii Archaebac. 1 12 30.6 ± 2.0 15 ± 2 -108.8
1.1.18.05. Arginine/agmatine antiporter (AdiC) 3hqk Salmonella enterica Bact. gram-neg inner 2 26 26.9 ± 1.0 1 ± 2 -155.6
1.1.19.01. Ammonia Channel 1u7g Escherichia coli Bact. gram-neg inner 3 33 28.0 ± 1.0 0 ± 1 -164.4
1.1.19.01. Ammonium transporter Amt-1 2b2f Archaeoglobus fulgidus Archaebac. 3 33 27.5 ± 0.6 0 ± 1 -177.8
1.1.19.01. Rh-like protein 3b9w Nitrosomonas europaea Bact. gram-neg inner 3 24 29.0 ± 1.0 0 ± 1 -184.6
1.1.19.01. Rh-like protein 3b9y Nitrosomonas europaea Bact. gram-neg inner 3 33 29.0 ± 1.0 0 ± 1 -184.5
1.1.19.01. Rhesus Glycoprotein RhCG 3hd6 Homo sapiens Eukaryo. plasma 3 36 30.5 ± 1.1 0 ± 1 -189.3
1.1.21.01. Sarcolipin 1jdm Homo sapiens Endoplasm. reticulum 1 1 28.9 ± 1.8 1 ± 7 -32.1
1.1.21.01. Phospholamban 1zll Homo sapiens Endoplasm. reticulum 5 5 31.5 ± 1.2 0 ± 1 -91.1
1.1.21.02. Na,K-ATPase regulatory protein FXYD1 (phospholemman) 2jo1 Homo sapiens Endoplasm. reticulum 1 1 30.7 ± 2.8 8 ± 3 -34.8
1.1.21.02. Na,K-ATPase regulatory protein FXYD1 (phospholemman) 2jp3 Rattus norvegicus Endoplasm. reticulum 1 1 32.5 ± 1.0 11 ± 6 -31.2
1.1.22.01. Potassium channel KcsA, full-length, closed 3eff Streptomyces lividans Bact. gram-pos plas. 12 12 31.8 ± 1.4 0 ± 1 -126.3
1.1.22.01. Potassium channel, open state 3e86 Bacillus cereus Bact. gram-pos plas. 4 12 26.0 ± 1.2 0 ± 1 -101.3
1.1.22.01. Potassium channel Kv1.2. 2a79 Rattus norvegicus Eukaryo. plasma 4 28 26.3 ± 0.8 0 ± 1 -200.6
1.1.22.01. Potassium channel KvAP, sensor domain 1ors Aeropyrum pernix Archaebac. 1 5 29.1 ± 2.8 24 ± 3 -65.8
1.1.22.01. Potassium channel Kv1.2., structure in a membrane-like environment 2r9r Rattus norvegicus Eukaryo. plasma 4 28 28.5 ± 0.7 0 ± 1 -286.8
1.1.22.01. Potassium channel KvAP 1orq Aeropyrum pernix Archaebac. 4 12 26.0 ± 1.5 0 ± 2 -94.0
1.1.22.01. Potassium channel KcsA 1r3j Streptomyces lividans Bact. gram-pos plas. 4 12 33.1 ± 1.0 0 ± 2 -119.1
1.1.22.01. Potassium channel KvAP 2a0l Aeropyrum pernix Archaebac. 4 12 27.5 ± 1.1 0 ± 1 -141.4
1.1.22.01. Potassium channel KcsA 1s5h Streptomyces coelicolor Bact. gram-pos plas. 4 12 33.5 ± 1.1 0 ± 2 -125.0
1.1.22.01. Potassium channel, closed state 2ahy Bacillus cereus Bact. gram-pos plas. 4 12 29.2 ± 1.1 0 ± 1 -116.4
1.1.22.01. Bacterial cyclic nucleotide regulated ion channel 3beh Rhizobium loti Bact. gram-neg inner 4 28 30.2 ± 1.0 0 ± 1 -240.7
1.1.22.02. Potassium channel Kirbac3.1 1xl6 Magnetospirillum magnetotacticum Bact. gram-neg inner 4 12 28.3 ± 1.5 0 ± 2 -89.0
1.1.22.02. Potassium channel Kirbac1.1 1p7b Burkholderia pseudomallei Bact. gram-neg inner 4 12 32.0 ± 0.6 0 ± 1 -145.2
1.1.22.02. Kir3.1-prokaryotic Kir channel chimera 2qks Burkholderia xenovorans Bact. gram-neg inner 4 12 34.0 ± 1.8 0 ± 1 -101.2
1.1.23.01. Mechanosensitive channel MscL 2oar Mycobacterium tuberculosis Bact. gram-pos plas. 5 10 35.0 ± 1.2 0 ± 1 -157.5
1.1.24.01. Mechanosensitive channel protein MscS, open state 2vv5 Escherichia coli Bact. gram-neg inner 7 21 25.0 ± 0.5 0 ± 0 -162.9
1.1.24.01. Mechanosensitive channel protein MscS, expanded state 2oau Escherichia coli Bact. gram-neg inner 7 14 23.7 ± 0.8 2 ± 2 -181.6
1.1.25.01. CorA magnesium transporter 2bbj Thermotoga maritima Bact. gram-neg inner 5 10 29.1 ± 1.2 0 ± 2 -103.9
1.1.26.01. Acetylcholine receptor 2bg9 Torpedo marmorata Eukaryo. plasma 5 20 31.0 ± 1.6 3 ± 2 -158.0
1.1.26.02. Ligand gated ion channel, inactive conformation 2vl0 Erwinia chrysanthemi Bact. gram-neg inner 5 20 35.0 ± 0.8 0 ± 1 -156.4
1.1.26.02. Ligand gated ion channel, active conformation 3eam Gloeobacter violaceus Bact. gram-neg inner 5 20 32.5 ± 1.6 0 ± 1 -196.6
1.1.27.01. Aquaporin-4 2d57 Rattus norvegicus Eukaryo. plasma 4 32 29.8 ± 1.1 0 ± 1 -154.5
1.1.27.01. Glycerol uptake facilitator 1ldf Escherichia coli Bact. gram-neg inner 4 32 26.6 ± 0.8 0 ± 0 -167.6
1.1.27.01. Aquaporin-0, open state 2b6p Bos taurus Eukaryo. plasma 4 32 28.3 ± 0.9 0 ± 1 -146.5
1.1.27.01. Aquaporin-5 3d9s Homo sapiens Eukaryo. plasma 4 32 29.5 ± 1.2 0 ± 1 -160.3
1.1.27.01. Aquaporin AQY1 2w2e Pichia pastoris Eukaryo. plasma 4 32 30.0 ± 0.9 0 ± 1 -148.2
1.1.27.01. Aquaporin-0 2b6o Ovis aries Eukaryo. plasma 4 32 30.5 ± 1.2 0 ± 1 -169.9
1.1.27.01. Aquaporin-1 1h6i Homo sapiens Eukaryo. plasma 4 32 25.0 ± 1.5 0 ± 1 -148.9
1.1.27.01. Aquaporin-1 1j4n Bos taurus Eukaryo. plasma 4 32 29.2 ± 1.2 0 ± 1 -150.9
1.1.27.01. Aquaporin Sopip2 1z98 Spinacia oleracea Eukaryo. plasma 4 32 27.5 ± 1.2 0 ± 1 -140.7
1.1.27.01. Aquaporin-0 1ymg Bos taurus Eukaryo. plasma 4 32 29.2 ± 0.9 0 ± 1 -155.3
1.1.27.01. Aquaporin Sopip2, open state 2b5f Spinacia oleracea Eukaryo. plasma 4 32 27.4 ± 1.0 1 ± 1 -144.0
1.1.27.01. Aquaporin Aqpm 2f2b Methanobacterium thermoautotrophicum Archaebac. 4 32 24.0 ± 1.2 0 ± 1 -132.8
1.1.27.01. Aquaporin-0 1sor Ovis aries Eukaryo. plasma 4 32 29.0 ± 1.0 0 ± 1 -153.8
1.1.27.01. Aquaporin-4 3gd8 Homo sapiens Eukaryo. plasma 4 32 27.9 ± 1.1 0 ± 1 -154.3
1.1.27.01. Aquaglyceroporin 3c02 Plasmodium falciparum Eukaryo. plasma 4 32 31.0 ± 1.6 0 ± 1 -155.3
1.1.27.01. Aquaporin Z 1rc2 Escherichia coli Bact. gram-neg inner 4 32 27.5 ± 1.5 0 ± 2 -149.6
1.1.28.01. Clc chloride channel 1ots Escherichia coli Bact. gram-neg inner 2 28 23.4 ± 1.6 0 ± 4 -135.2
1.1.28.01. Clc chloride channel 1kpl Salmonella typhimurium Bact. gram-neg inner 2 28 22.7 ± 1.8 0 ± 4 -143.0
1.1.29.01. Steryl-sulfatase 1p49 Homo sapiens Endoplasm. reticulum 1 2 32.0 ± 2.8 20 ± 3 -44.1
1.1.30.01. Protease glpG 2nr9 Haemophilus influenzae Bact. gram-neg inner 1 6 22.6 ± 2.0 15 ± 3 -61.8
1.1.30.01. Protease glpG 2ic8 Escherichia coli Bact. gram-neg inner 1 6 28.4 ± 2.0 17 ± 5 -69.3
1.1.31.01. Zeta-zeta dimer of T cell receptor 2hac Homo sapiens Eukaryo. plasma 2 2 32.5 ± 2.0 4 ± 8 -40.3
1.1.32.01. Outer membrane lipoprotein Wza 2j58 Escherichia coli Bact. gram-neg outer 8 8 31.0 ± 1.0 0 ± 1 -127.9
1.1.33.01. Disulfide bond formation protein B 2zuq Escherichia coli Bact. gram-neg inner 1 4 25.9 ± 2.0 39 ± 5 -48.4
1.1.33.01. Disulfide bond formation protein B 2k74 Escherichia coli Bact. gram-neg inner 1 4 26.0 ± 1.8 26 ± 5 -56.7
1.1.33.01. DsbB - DsbA complex 2hi7 Escherichia coli Bact. gram-neg inner 1 4 23.8 ± 1.5 30 ± 3 -44.1
1.1.33.01. DsbB - DsbA complex 2zup Escherichia coli Bact. gram-neg inner 1 4 21.5 ± 3.2 23 ± 5 -24.4
1.1.34.01. Cytochrome c nitrite reductase complex 2j7a Desulfovibrio vulgaris Bact. gram-neg inner 2 2 32.6 ± 1.0 1 ± 3 -66.5
1.1.35.01. Stannin 1zza Homo sapiens Mitochon. outer 1 1 35.4 ± 2.2 23 ± 12 -27.6
1.1.36.01. Domain of glycophorin A 1afo Homo sapiens Eukaryo. plasma 2 2 31.3 ± 2.2 2 ± 10 -51.5
1.1.37.01. Major coat protein 1ifi Bacteriophage fd Secreted 15 15 30.0 ± 1.5 0 ± 1 -40.1
1.1.37.01. Major coat protein 1ifk Bacteriophage f1 Secreted 15 15 29.0 ± 1.2 0 ± 1 -64.1
1.1.37.02. Major coat protein 1hgz Bacteriophage ph75 Secreted 15 15 28.3 ± 0.9 11 ± 0 -55.7
1.1.37.02. Major coat protein 1ifp Bacteriophage pf3 Secreted 12 12 32.8 ± 0.2 10 ± 0 -107.0
1.1.38.01. Type IV pilin 2pil Neisseria gonorrhoeae Secreted 1 1 28.5 ± 3.5 26 ± 13 -33.1
1.1.39.01. Pulmonary surfactant-associated protein C 1spf Sus scrofa Secreted 1 1 32.8 ± 5.8 21 ± 7 -39.8
1.1.40.01. Lekotriene C4 synthase 2uuh Homo sapiens Endoplasm. reticulum 3 12 26.3 ± 1.2 0 ± 1 -58.2
1.1.40.01. Microsomal glutathione S-transferase 1 2h8a Rattus norvegicus Endoplasm. reticulum 3 12 29.5 ± 1.7 0 ± 1 -72.2
1.1.40.01. FLAP protein (5-lipoxygenase activator) 2q7r Homo sapiens Endoplasm. reticulum 3 12 22.5 ± 4.7 0 ± 2 -81.4
1.1.40.01. Microsomal prostaglandin E synthase 1 3dww Homo sapiens Endoplasm. reticulum 3 12 33.4 ± 1.8 1 ± 3 -113.3
1.1.41.01. Magnesium ion transporter-E (MgtE) 2yvx Thermus thermophilus Bact. gram-neg inner 2 10 32.0 ± 1.5 0 ± 2 -95.5
1.1.42.01. Acid-sensing ion channel 2qts Gallus gallus Eukaryo. plasma 3 6 37.5 ± 2.2 13 ± 2 -76.9
1.1.43.01. Ferrous-iron efflux pump fieF 2qfi Escherichia coli Bact. gram-neg inner 2 12 41.2 ± 2.5 0 ± 3 -36.3
1.1.43.01. Ferrous-iron efflux pump fieF 3h90 Escherichia coli Bact. gram-neg inner 2 12 30.0 ± 1.3 0 ± 3 -117.5
1.1.44.01. Site-2 protease (S2P) metalloprotease 3b4r Methanococcus jannaschii Archaebac. 1 6 26.4 ± 2.0 26 ± 4 -84.6
1.1.45.01. M2 transmembrane domain tetramer, open state, ligand-free 3bkd Influenza virus Viral 4 4 24.8 ± 1.4 1 ± 3 -69.3
1.1.45.01. M2 transmembrane domain tetramer, open state, complex with amantadine 3c9j Influenza virus Viral 4 4 25.0 ± 1.0 7 ± 4 -76.5
1.1.45.01. M2 transmembrane domain tetramer, closed state 2rlf Influenza virus Viral 4 4 31.4 ± 1.8 4 ± 7 -79.3
1.1.46.01. Receptor tyrosine kinase EphA1 2k1k Homo sapiens Eukaryo. plasma 2 2 28.4 ± 1.2 0 ± 3 -51.4
1.1.46.01. Receptor tyrosine kinase EphA2 2k9y Homo sapiens Eukaryo. plasma 2 2 36.5 ± 1.5 0 ± 5 -52.8
1.1.46.01. Transmembrane domain of growth factor receptor (EGF) ErbB2 2jwa Homo sapiens Eukaryo. plasma 2 2 33.5 ± 2.2 0 ± 5 -60.5
1.1.47.01. Polysulfide reductase 2vpz Thermus thermophilus Bact. gram-neg inner 2 16 27.3 ± 1.1 0 ± 1 -130.1
1.1.48.01. Anion-specific porin B 2vql Corinebacterium glutamicum Bact. gram-neg outer 1 0 6.2 ± 1.0 85 ± 3 -11.4
1.1.49.01. BNip3 transmembrane domain dimer 2j5d Homo sapiens Mitochon. outer 2 2 28.5 ± 2.0 11 ± 6 -42.4
1.1.49.01. BNip3 transmembrane domain dimer 2ka1 Homo sapiens Mitochon. outer 2 2 34.0 ± 3.0 11 ± 11 -49.7
1.1.50.01. Integrin alphaIIb-beta3 transmembrane complex 2k9j Homo sapiens Eukaryo. plasma 2 2 38.3 ± 2.2 6 ± 11 -71.7
1.1.51.01. Human CD4 2klu Homo sapiens Eukaryo. plasma 1 1 33.9 ± 3.8 12 ± 14 -34.9
1.1.52.01. Connexin 26 gap junction channel (beta-2 protein) 2zw3 Spodoptera frugiperda Eukaryo. plasma 6 24 32.5 ± 1.3 0 ± 1 -170.5
1.1.53.01. Diacylglycerol kinase (DAGK) 2kdc Escherichia coli Bact. gram-neg inner 3 9 33.5 ± 0.0 0 ± 1 -77.1
1.1.54.01. SNARE complex (syntaxin 1A, SNAP-25 and synaptobrevin 2) 3hd7 Rattus norvegicus Eukaryo. plasma 2 2 27.2 ± 2.0 2 ± 7 -41.9
1.1.55.01. Pore-forming haemolysin E (HlyE) 2wcd Escherichia coli Secreted 12 36 31.0 ± 0.5 0 ± 1 -203.1
1.1.56.01. ATP-gated P2X4 ion channel in the closed state 3h9v Danio rerio Eukaryo. plasma 3 6 25.5 ± 1.3 0 ± 2 -67.7
1.2.01.01. Outer membrane protein X (OMPX) 1qj8 Escherichia coli Bact. gram-neg outer 1 8 23.9 ± 1.9 9 ± 9 -36.7
1.2.01.01. Outer membrane protein NspA 1p4t Neisseria meningitidis Bact. gram-neg outer 1 8 24.3 ± 1.9 10 ± 5 -49.3
1.2.01.01. Transmembrane beta-barrel platform protein 2jmm Designed proteins Bact. gram-neg outer 8 8 22.6 ± 1.7 3 ± 5 -34.0
1.2.01.01. Outer membrane protein A from Klebsiella 2k0l Klebsiella pneumoniae Bact. gram-neg outer 1 8 22.2 ± 2.8 14 ± 8 -32.4
1.2.01.01. Outer membrane protein W 2f1v Escherichia coli Bact. gram-neg outer 1 8 25.0 ± 1.5 9 ± 6 -46.0
1.2.01.01. Outer membrane protein A (OMPA) 1qjp Escherichia coli Bact. gram-neg outer 1 8 24.9 ± 2.2 8 ± 6 -36.7
1.2.01.02. Lipid A deacylase PagL 2erv Pseudomonas aeruginosa Bact. gram-neg outer 1 8 23.0 ± 2.0 23 ± 4 -42.3
1.2.01.02. Lipid A acylase PagP 1thq Escherichia coli Bact. gram-neg outer 1 8 22.0 ± 2.0 26 ± 3 -38.7
1.2.01.03. Major outer membrane protein from Thermus thermophilus 3dzm Thermus thermophilus Bact. gram-neg outer 1 8 28.2 ± 1.7 4 ± 5 -59.2
1.2.02.01. Outer membrane protease OmpT 1i78 Escherichia coli Bact. gram-neg outer 1 10 25.8 ± 1.2 3 ± 4 -54.8
1.2.02.02. Outer membrane adhesin/invasin OpcA 1k24 Neisseria meningitidis Bact. gram-neg outer 1 10 25.2 ± 1.6 6 ± 4 -51.9
1.2.03.01. Serine protease EspP 2qom Escherichia coli Bact. gram-neg outer 1 12 26.1 ± 2.5 8 ± 5 -63.6
1.2.03.01. Autotransporter NalP 1uyn Neisseria meningitidis Bact. gram-neg outer 1 12 25.5 ± 2.2 5 ± 3 -62.2
1.2.03.01. Autotransporter NalP, different conformation 1uyo Neisseria meningitidis Bact. gram-neg outer 1 12 23.2 ± 2.0 7 ± 4 -55.6
1.2.04.01. Autotransporter Hia 2gr7 Haemophilus influenzae Bact. gram-neg outer 3 15 21.5 ± 1.5 0 ± 2 -53.8
1.2.04.01. Autotransporter Hia, a different conformation 3emo Haemophilus influenzae Bact. gram-neg outer 3 12 20.9 ± 1.5 1 ± 4 -50.2
1.2.05.01. Outer membrane phospholipase A, monomer 1qd6C Escherichia coli Bact. gram-neg outer 1 12 23.2 ± 1.5 3 ± 3 -52.8
1.2.05.01. Outer membrane phospholipase A 1qd6 Escherichia coli Bact. gram-neg outer 1 12 22.2 ± 1.1 0 ± 1 -91.6
1.2.06.01. Bacterial Nucleoside Transporter Ts 1tly Escherichia coli Bact. gram-neg outer 1 12 23.3 ± 2.2 5 ± 5 -49.1
1.2.07.01. Toluene transporter TbuX 3bry Ralstonia pickettii Bact. gram-neg outer 1 14 24.7 ± 1.8 4 ± 4 -65.0
1.2.07.01. Toluene transporter TodX 3bs0 Pseudomonas putida Bact. gram-neg outer 14 14 22.2 ± 1.4 5 ± 3 -65.6
1.2.07.01. Fatty Acid Transporter FadL 1t16 Escherichia coli Bact. gram-neg outer 1 14 24.5 ± 1.5 4 ± 3 -60.0
1.2.07.01. FadL homologue 3dwo Pseudomonas aeruginosa Bact. gram-neg outer 1 14 24.5 ± 1.7 2 ± 3 -63.2
1.2.08.01. Outer membrane protein G (OMPG) 2f1c Escherichia coli Bact. gram-neg outer 1 14 23.0 ± 1.3 1 ± 2 -60.3
1.2.08.01. Outer membrane protein G (OMPG), open state 2iwv Escherichia coli Bact. gram-neg outer 1 14 23.7 ± 1.4 2 ± 4 -64.2
1.2.08.01. Outer membrane protein G (OMPG), closed state 2iww Escherichia coli Bact. gram-neg outer 1 14 23.4 ± 1.5 1 ± 2 -67.0
1.2.09.01. Porin OmpF 1hxx Escherichia coli Bact. gram-neg outer 3 48 24.2 ± 0.8 0 ± 1 -147.6
1.2.09.01. Osmoporin OMPC 2j1n Escherichia coli Bact. gram-neg outer 3 48 24.4 ± 0.8 0 ± 1 -144.4
1.2.09.01. Porin 1osm Klebsiella pneumoniae Bact. gram-neg outer 3 48 23.5 ± 0.6 0 ± 1 -152.4
1.2.09.01. Anion-selective porin 1e54 Comamonas acidovorans Bact. gram-neg outer 3 48 24.5 ± 1.1 1 ± 1 -161.9
1.2.09.01. Phosphoporin (PhoE) 1pho Escherichia coli Bact. gram-neg outer 3 48 23.3 ± 0.8 0 ± 1 -148.9
1.2.09.01. Osmoporin OMPC, isoform 1 2ixx Escherichia coli Bact. gram-neg outer 3 48 24.9 ± 1.0 0 ± 1 -154.7
1.2.09.01. Osmoporin OMPC, isoform 2 2ixw Escherichia coli Bact. gram-neg outer 3 48 24.5 ± 1.0 0 ± 1 -141.4
1.2.09.02. Porin 2por Rhodobacter capsulatus Bact. gram-neg outer 3 48 22.5 ± 0.9 0 ± 1 -131.3
1.2.09.02. Porin 3prn Rhodopseudomonas blastica Bact. gram-neg outer 3 48 22.2 ± 0.9 0 ± 0 -147.6
1.2.09.03. Porin OprP 2o4v Pseudomonas aeruginosa Bact. gram-neg outer 3 48 23.0 ± 1.4 0 ± 1 -144.4
1.2.10.01. Maltoporin 1af6 Escherichia coli Bact. gram-neg outer 3 54 25.0 ± 0.7 0 ± 0 -151.2
1.2.10.01. Maltoporin 2mpr Salmonella typhimurium Bact. gram-neg outer 3 54 24.0 ± 0.7 0 ± 0 -139.4
1.2.10.01. Sucrose-specific porin 1a0s Salmonella typhimurium Bact. gram-neg outer 3 54 22.5 ± 0.6 0 ± 1 -124.0
1.2.11.01. Outer membrane porin OprD 2odj Pseudomonas aeruginosa Bact. gram-neg outer 1 18 21.3 ± 1.5 6 ± 2 -68.6
1.2.11.01. BenF-like porin 3jty Pseudomonas fluorescens Bact. gram-neg outer 1 18 23.3 ± 2.5 4 ± 3 -66.5
1.2.11.01. Protein OpdK 2qtk Pseudomonas aeruginosa Bact. gram-neg outer 1 18 21.8 ± 2.0 5 ± 4 -70.1
1.2.12.01. Filamentous hemagglutinin transporter FhaC 2qdz Bordetella pertussis Bact. gram-neg outer 1 16 22.3 ± 1.1 6 ± 2 -74.5
1.2.13.01. Outer membrane cobalamin transporter BtuB, meso form 2guf Escherichia coli Bact. gram-neg outer 22 22 21.5 ± 1.2 2 ± 2 -80.9
1.2.13.01. Outer membrane cobalamin transporter BtuB 1nqe Escherichia coli Bact. gram-neg outer 1 22 21.1 ± 1.3 1 ± 1 -79.5
1.2.13.01. Outer membrane cobalamin transporter BtuB, complex with TonB 2gsk Escherichia coli Bact. gram-neg outer 1 22 21.7 ± 1.2 2 ± 2 -84.1
1.2.13.01. Outer membrane receptor FauA 3efm Bordetella pertussis Bact. gram-neg outer 1 22 23.0 ± 1.3 4 ± 2 -85.2
1.2.13.02. Ferric hydroxamate uptake receptor FhuA 1qfg Escherichia coli Bact. gram-neg outer 1 22 23.5 ± 1.0 0 ± 1 -86.9
1.2.13.02. Ferric enterobactin receptor FepA 1fep Escherichia coli Bact. gram-neg outer 1 22 24.5 ± 1.2 1 ± 2 -93.1
1.2.13.02. Outer membrane transporter FecA 1kmo Escherichia coli Bact. gram-neg outer 1 22 22.9 ± 1.2 4 ± 1 -81.3
1.2.13.02. Fe(III)-pyochelin receptor FptA 1xkw Pseudomonas aeruginosa Bact. gram-neg outer 1 22 23.0 ± 1.3 4 ± 2 -92.7
1.2.13.02. Hemophore receptor HasR 3csl Serratia marcescens Bact. gram-neg outer 1 22 23.0 ± 1.3 1 ± 3 -80.6
1.2.13.02. Ferric hydroxamate uptake receptor FhuA, complex with TonB 2grx Escherichia coli Bact. gram-neg outer 1 22 24.5 ± 0.7 2 ± 2 -88.9
1.2.13.02. Colicin I receptor complex with binding domain of Colicin Ia 2hdi Escherichia coli Bact. gram-neg outer 1 22 22.5 ± 1.3 1 ± 2 -81.2
1.2.13.02. Pyoverdine Outer Membrane Receptor FpvA 2iah Pseudomonas aeruginosa Bact. gram-neg outer 1 22 22.5 ± 1.2 3 ± 2 -85.8
1.2.13.02. Colicin I receptor 2hdf Escherichia coli Bact. gram-neg outer 1 22 22.0 ± 1.4 2 ± 2 -81.1
1.2.13.02. Outer membrane heme transporter ShuA 3fhh Shigella dysenteriae Bact. gram-neg outer 1 22 23.0 ± 1.3 2 ± 2 -75.4
1.2.13.02. Outer membrane transporter FecA, different conformation 1kmp Escherichia coli Bact. gram-neg outer 1 22 24.6 ± 1.2 3 ± 2 -85.4
1.2.14.01. Outer membrane protein TolC 1ek9 Escherichia coli Bact. gram-neg outer 3 12 25.0 ± 1.5 0 ± 4 -61.7
1.2.14.01. Multidrug Resistance (VceC) protein 1yc9 Vibrio cholerae Bact. gram-neg outer 3 12 23.5 ± 1.2 0 ± 1 -60.8
1.2.14.01. Drug-Discharge Outer Membrane Protein, OprM 1wp1 Pseudomonas aeruginosa Bact. gram-neg outer 3 12 25.0 ± 2.8 0 ± 2 -63.3
1.2.15.01. Alpha-hemolysin 7ahl Staphylococcus aureus Secreted 7 14 24.5 ± 1.3 0 ± 1 -65.1
1.2.15.02. Porin MspA 1uun Mycobacterium smegmatis Bact. gram-pos cell wall 8 16 43.8 ± 0.9 0 ± 2 -137.1
1.2.16.01. P pilus usher PapC translocation domain 2vqi Escherichia coli Bact. gram-neg outer 1 24 18.4 ± 1.3 5 ± 2 -63.8
1.2.17.01. VDAC-1 channel 3emn Mus musculus Mitochon. outer 1 19 22.5 ± 1.3 2 ± 2 -62.6
1.2.17.01. VDAC-1 channel 2k4t Homo sapiens Mitochon. outer 1 19 20.6 ± 1.1 1 ± 2 -40.6
1.2.17.01. VDAC-1 channel 2jk4 Homo sapiens Mitochon. outer 1 19 20.4 ± 2.1 5 ± 5 -51.9
1.2.18.01. Lipid A deacylase LpxR 3fid Salmonella typhimurium Bact. gram-neg outer 1 12 27.4 ± 3.0 13 ± 6 -61.5
1.2.19.01. Acidic sugar-specific porin NanC 2wjr Escherichia coli Bact. gram-neg outer 1 12 19.0 ± 1.5 9 ± 5 -45.6