Family » 1.1.01.02. G-protein coupled receptors - Orientations of Proteins in Membranes (OPM) database

Type:1. Transmembrane (2 classes)
Class:1.1. Alpha-helical transmembrane (54 superfamilies)
Superfamily:1.1.01. Rhodopsin-like proteins (2 families)
Family:
1.1.01.02. G-protein coupled receptors

A2A adenosine receptor bound to antagonist ZM241385

Homo sapiens (3eml)

Beta1-adrenergic receptor

Meleagris gallopavo (2vt4)

Beta2-adrenergic receptor

Homo sapiens (2rh1, 2r4r, 2r4s, 3d4s)

Cholecystokinin A receptor fragment

Homo sapiens (1d6g)

Melanocortin-4 receptor model (active state) with agonist NDP-MSH

Homo sapiens (2iqr)

Melanocortin-4 receptor model (inactive state) with antagonist AGRP

Homo sapiens (2iqv)

Mu-opioid receptor model (inactive state) with antagonist

Rattus norvegicus (2iql)

Mu-opioid receptor model in active state with agonist

Rattus norvegicus (2iqo)

Opsin, complex with C-terminal peptide of Galpha subunit of transducin

Bos taurus (3dqb, 3cap)

Opsin, retinal-free state

Bos taurus (3cap, 1f88, 1gzm, 1hzx, 1l9h, 1u19, 2g87, 2hpy, 2i35, 2i36, 2i37, 2iqk, 2j4y, 2ped, 3dqb)

Rhodopsin

Bos taurus (1gzm, 1f88, 1hzx, 1jfp, 1l9h, 1ln6, 1u19, 2g87, 2hpy, 2i35, 2i36, 2i37, 2iqk, 2ped, 3c9l, 3c9m, 3cap)

Rhodopsin, a dimer

Bos taurus (2i36, 1f88, 1gzm, 1hzx, 1l9h, 1u19, 2g87, 2hpy, 2i35, 2i37, 2iqk, 2ped, 3cap)

Rhodopsin, a photobleached state

Bos taurus (2i37, 1f88, 1gzm, 1hzx, 1l9h, 1u19, 2g87, 2hpy, 2i35, 2i36, 2iqk, 2ped, 3cap)

Squid rhodopsin dimer

Todarodes pacificus (2z73, 2ziy)

TM1-TM2 fragment of fungal STE2 receptor

Saccharomyces cerevisiae (2k9p)

1.1.01.02. G-protein coupled receptors (15 proteins)

Protein Name	PDB ID	Species	Localization	Num. Subunits	Num. TM Sec. Structs.	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
A2A adenosine receptor bound to antagonist ZM241385	3eml	Homo sapiens	Eukaryo. plasma	1	7	33.2 ± 2.2	8 ± 4	-85.1
Beta1-adrenergic receptor	2vt4	Meleagris gallopavo	Eukaryo. plasma	1	7	32.7 ± 1.5	6 ± 4	-95.7
Beta2-adrenergic receptor	2rh1	Homo sapiens	Eukaryo. plasma	1	7	31.4 ± 1.3	8 ± 3	-84.3
Cholecystokinin A receptor fragment	1d6g	Homo sapiens	Eukaryo. plasma	2	0	8.0 ± 0.8	89 ± 7	-16.1
Melanocortin-4 receptor model (active state) with agonist NDP-MSH	2iqr	Homo sapiens	Eukaryo. plasma	1	7	34.5 ± 1.5	18 ± 3	-80.2
Melanocortin-4 receptor model (inactive state) with antagonist AGRP	2iqv	Homo sapiens	Eukaryo. plasma	1	7	33.5 ± 1.5	19 ± 3	-75.3
Mu-opioid receptor model (inactive state) with antagonist	2iql	Rattus norvegicus	Eukaryo. plasma	1	7	35.0 ± 1.0	9 ± 3	-97.7
Mu-opioid receptor model in active state with agonist	2iqo	Rattus norvegicus	Eukaryo. plasma	1	7	35.3 ± 1.6	1 ± 4	-95.7
Opsin, complex with C-terminal peptide of Galpha subunit of transducin	3dqb	Bos taurus	Eukaryo. plasma	1	7	31.5 ± 1.4	6 ± 3	-86.3
Opsin, retinal-free state	3cap	Bos taurus	Eukaryo. plasma	1	7	31.4 ± 1.3	6 ± 4	-86.0
Rhodopsin	1gzm	Bos taurus	Eukaryo. plasma	1	7	32.4 ± 1.7	8 ± 3	-91.3
Rhodopsin, a dimer	2i36	Bos taurus	Eukaryo. plasma	2	14	30.5 ± 1.4	0 ± 1	-161.5
Rhodopsin, a photobleached state	2i37	Bos taurus	Eukaryo. plasma	1	7	31.9 ± 1.4	5 ± 4	-88.6
Squid rhodopsin dimer	2z73	Todarodes pacificus	Eukaryo. plasma	2	14	33.5 ± 1.1	0 ± 2	-167.5
TM1-TM2 fragment of fungal STE2 receptor	2k9p	Saccharomyces cerevisiae	Eukaryo. plasma	1	2	31.5 ± 2.0	5 ± 7	-25.7