Superfamily » 1.1.15. Pentameric ligand-gated ion channels (2 families) <a href="http://www.tcdb.org/search/result.php?tc=1.A.9" class="external" target="_blank">1.A.9 (TCDB)</a> <a href="http://pfam.sanger.ac.uk/family/PF02932" class="external" target="_blank">PF02932</a>, <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF02932" class="external" target="_blank">PDBsum</a> - Orientations of Proteins in Membranes (OPM) database

Type:1. Transmembrane (3 classes)
Class:1.1. Alpha-helical polytopic (72 superfamilies)
Superfamily:1.1.15. Pentameric ligand-gated ion channels (2 families) 1.A.9 (TCDB) PF02932, PDBsum
Family:
1. 1.1.15.01.
  Ligand-gated ion channel of neurotransmitter receptors 1.A.9 (TCDB) PF02932, PDBsum
  Glutamate-gated chloride channel GluCl alpha
  
  Caenorhabditis elegans
  (3rhw, 3ri5, 3ria, 3rif)
  
  Glycine receptor, alpha1 subunit
  
  Homo sapiens
  (1vry, 1mot)
  
  Nicotinic acetylcholine receptor, alpha4 subunit, in LDAO micelles
  
  Homo sapiens
  (2lly)
  
  Nicotinic acetylcholine receptor, beta2 subunit, in hexafluoroisopropanol/water
  
  Homo sapiens
  (2ksr)
  
  Nicotinic acetylcholine receptor, beta2 subunit, in LDAO micelles
  
  Homo sapiens
  (2lm2)
  
  Nicotinic acetylcholine receptor, closed state
  
  Torpedo marmorata
  (2bg9, 1oed)
  
  Nicotinic acetylcholine receptor, partially open state
  
  Torpedo marmorata
  (4aq9, 4aq5)
2. 1.1.15.02.
  Prokaryotic pentameric ligand-gated ion channels 1.A.9 (TCDB) PF02932, PDBsum
  Proton-gated ion channel, different conformation
  
  Erwinia chrysanthemi
  (4a97, 3zkr, 4a96, 4a98)
  
  Proton-gated ion channel, different inactive conformation
  
  Erwinia chrysanthemi
  (3uq7, 3uq4, 3uq5)
  
  Proton-gated ion channel, inactive conformation
  
  Erwinia chrysanthemi
  (2vl0, 2yks, 2yn6, 2yoe, 3rqu, 3rqw)
  
  Proton-gated ion channel, inactive, complex with acetylcholine
  
  Erwinia chrysanthemi
  (3rqw)
  
  Proton-gated ion channel, locally closed
  
  Gloeobacter violaceus
  (3tlw, 3tls, 3tlt, 3tlu, 3tlv, 3uu3, 3uu4, 3uu5, 3uu6, 3uu8, 3uub)
  
  Proton-gated ion channel, open state
  
  Gloeobacter violaceus
  (3eam, 2xq3, 2xq4, 2xq5, 2xq6, 2xq7, 2xq8, 2xq9, 2xqa, 3ehz, 3ei0, 3igq, 3lsv, 3p4w, 3p50, 4f8h, 4hfb, 4hfc, 4hfd, 4hfe, 4hfh, 4hfi, 4il4, 4il9, 4ila, 4ilb, 4ilc, 4ire)

1.1.15. Pentameric ligand-gated ion channels (2 families) 1.A.9 (TCDB) PF02932, PDBsum (13 proteins)

Family	Protein Name	PDB ID	Species	Localization	Num. Subunits	Num. TM Sec. Structs.	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
1.1.15.02.	Proton-gated ion channel, locally closed	3tlw	Gloeobacter violaceus	Bact. Gram-neg inner	5	20	34.0 ± 1.6	0 ± 0	-190.3
1.1.15.02.	Proton-gated ion channel, open state	3eam	Gloeobacter violaceus	Bact. Gram-neg inner	5	20	32.7 ± 0.9	0 ± 1	-183.4
1.1.15.02.	Proton-gated ion channel, different conformation	4a97	Erwinia chrysanthemi	Bact. Gram-neg inner	5	40	31.8 ± 0.5	0 ± 0	-125.8
1.1.15.01.	Nicotinic acetylcholine receptor, closed state	2bg9	Torpedo marmorata	Eukaryo. plasma	5	20	30.1 ± 1.1	3 ± 0	-119.6
1.1.15.02.	Proton-gated ion channel, inactive, complex with acetylcholine	3rqw	Erwinia chrysanthemi	Bact. Gram-neg inner	5	20	29.8 ± 0.4	0 ± 0	-118.8
1.1.15.01.	Nicotinic acetylcholine receptor, partially open state	4aq9	Torpedo marmorata	Eukaryo. plasma	5	20	30.8 ± 0.8	2 ± 0	-109.5
1.1.15.01.	Glutamate-gated chloride channel GluCl alpha	3rhw	Caenorhabditis elegans	Eukaryo. plasma	5	20	30.2 ± 0.7	0 ± 0	-107.9
1.1.15.02.	Proton-gated ion channel, inactive conformation	2vl0	Erwinia chrysanthemi	Bact. Gram-neg inner	5	20	31.8 ± 1.3	0 ± 0	-107.6
1.1.15.02.	Proton-gated ion channel, different inactive conformation	3uq7	Erwinia chrysanthemi	Bact. Gram-neg inner	5	20	32.0 ± 1.6	0 ± 1	-92.6
1.1.15.01.	Nicotinic acetylcholine receptor, alpha4 subunit, in LDAO micelles	2lly	Homo sapiens	Eukaryo. plasma	1	4	29.2 ± 1.2	8 ± 1	-49.2
1.1.15.01.	Nicotinic acetylcholine receptor, beta2 subunit, in LDAO micelles	2lm2	Homo sapiens	Eukaryo. plasma	1	4	29.2 ± 1.6	14 ± 2	-48.8
1.1.15.01.	Nicotinic acetylcholine receptor, beta2 subunit, in hexafluoroisopropanol/water	2ksr	Homo sapiens	Eukaryo. plasma	1	4	29.1 ± 2.2	16 ± 1	-47.0
1.1.15.01.	Glycine receptor, alpha1 subunit	1vry	Homo sapiens	Eukaryo. plasma	1	2	23.2 ± 3.7	5 ± 9	-25.3