Superfamily » 2.4.16. Scorpion toxin-like knottin (11 families) <a href="http://pfam.sanger.ac.uk/clan/CL0054" class="external" target="_blank">CL0054</a>, <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=CL0054" class="external" target="_blank">PDBsum</a> - Orientations of Proteins in Membranes (OPM) database

Type:2. Monotopic/peripheral (4 classes)
Class:2.4. Alpha + Beta monotopic/peripheral (50 superfamilies)
Superfamily:2.4.16. Scorpion toxin-like knottin (11 families) CL0054, PDBsum
Family:
1. 2.4.16.01.
  Long-chain scorpion toxins 8.B.1 (TCDB) PF00537, PDBsum
  Alpha-insect toxin LqhaIT
  
  Leiurus quinquestriatus hebraeus
  (2yeo, 1lgh, 1lqi, 2asc, 2atb)
  
  Alpha-insect toxin Lqq3
  
  Leiurus quinquestriatus quinquestriatus
  (1lqq)
  
  Alpha-like neurotoxin BmK-I
  
  Buthus martensii
  (1djt, 1chz, 1sn1, 1t7a, 1t7b, 1t7e, 1zu3, 1zut, 1zve, 1zvg, 1zyv, 1zyw)
  
  Alpha-like toxin CsEv5
  
  Centruroides sculpturatus (Bark scorpion)
  (1i6f, 1i6g, 1nh5)
  
  Alpha-mammal toxin AaH2
  
  Androctonus australis (Sahara scorpion)
  (1aho, 1ptx, 1seg)
  
  Alpha-mammal toxin BmK-M8
  
  Mesobuthus martensii (Manchurian scorpion)
  (1snb)
  
  Alpha-toxin Cn12
  
  Centruroides noxius (Mexican scorpion)
  (1pe4)
  
  Alpha-toxin CsE5
  
  Centruroides sculpturatus (Bark scorpion)
  (1nra, 1nrb)
  
  Beta-insect depressant toxin LqhIT2
  
  Leiurus quinquestriatus hebraeus
  (2i61)
  
  Beta-insect excitatory toxin BmK IT-AP
  
  Mesobuthus martensii (Manchurian scorpion)
  (1t0z)
  
  Beta-insect excitatory toxin BmKIT1
  
  Mesobuthus martensii (Manchurian scorpion)
  (1wwn)
  
  Beta-mammal toxin Cn2
  
  Centruroides noxius (Mexican scorpion)
  (2yc1, 1cn2)
  
  Beta-toxin Cn5
  
  Centruroides noxius (Mexican scorpion)
  (2kja)
  
  Beta-toxin CsEI
  
  Centruroides sculpturatus (Bark scorpion)
  (1b3c, 2b3c)
  
  Kurtoxin
  
  Parabuthus transvaalicus
  (1t1t)
  
  LQH III alpha-like toxin
  
  Leiurus quinquestriatus hebraeus
  (1fh3, 1bmr)
  
  Neurotoxin
  
  Buthus tamulus
  (1dq7, 2a7t)
  
  Neurotoxin 2
  
  Centruroides sculpturatus (Bark scorpion)
  (1jza, 1jzb)
  
  Neurotoxin BmK-M10
  
  Mesobuthus martensii (Manchurian scorpion)
  (2kbk)
  
  Toxin Bmka2
  
  Mesobuthus martensii (Manchurian scorpion)
  (2kbj, 2kbh)
  
  Toxin BmKaIT1
  
  Mesobuthus martensii (Manchurian scorpion)
  (1omy, 2e0h)
  
  Toxin CsEv1
  
  Centruroides sculpturatus (Bark scorpion)
  (1vna, 1vnb)
  
  Toxin CsEv3
  
  Centruroides sculpturatus (Bark scorpion)
  (2sn3)
  
  Toxin VII
  
  Tityus serrulatus
  (1npi, 1b7d)
  
  Tx10 alpha-like toxin
  
  Buthus martensii
  (1kv0)
2. 2.4.16.02.
  Arthropod defensins 1.C.47 (TCDB) PF01097, PDBsum
  Defensin
  
  Anopheles gambiae (African malaria mosquito)
  (2nz3, 2e3e, 2e3f, 2e3g, 2ny8, 2ny9)
  
  Crassostrea gigas (Pacific oyster)
  (2b68)
  
  Defensin ARD1
  
  Archaeoprepona demophon
  (1ozz, 1p00, 1p0a)
  
  Defensin heliomicin
  
  Heliothis virescens (Tobacco budworm moth)
  (1i2u, 1i2v)
  
  Defensin MGD-1
  
  Mytilus galloprovincialis (Mediterranean mussel)
  (1fjn)
  
  Drosomycin
  
  Drosophila melanogaster
  (1myn)
  
  Nasonin
  
  Nasonia vitripennis (Parasitic wasp)
  (2koz, 2kp0)
  
  Phormicin
  
  Protophormia terraenovae (Northern blowfly)
  (1ica)
  
  Sapecin
  
  Sarcophaga peregrina
  (1l4v)
  
  Termicin
  
  Pseudacanthotermes spiniger
  (1mm0)
3. 2.4.16.03.
  Short-chain scorpion toxins PF00451, PDBsum
  Charybdotoxin
  
  Leiurus quinquestriatus hebraeus
  (2crd, 1bah)
  
  Chlorotoxin
  
  Leiurus quinquestriatus quinquestriatus
  (1chl)
  
  Potassium channel toxin alpha-KTx 3.1
  
  Androctonus mauretanicus mauretanicus (Scorpion)
  (3odv, 1ktx, 1ktx, 1xsw, 1xsw, 2ktx, 2ktx, 2uvs, 2uvs)
  
  Potassium channel toxin gamma-KTx 1.1
  
  Centruroides noxius (Mexican scorpion)
  (1ne5, 1px9)
  
  Toxin I5a
  
  Buthus eupeus
  (1sis)
4. 2.4.16.04.
  Plant defensins 1.C.45 (TCDB) PF00304, PDBsum
  Antifungal protein 1
  
  Raphanus sativus
  (1ayj)
  
  Defensin
  
  Pachyrhizus erosus
  (3psm)
  
  Vigna radiata (Mung bean)
  (1ti5)
  
  Defensin 1
  
  Pisum sativum
  (1jkz)
  
  Defensin 2 (PDF1)
  
  Vigna radiata (Mung bean)
  (2gl1)
  
  Defensin-like protein
  
  Nicotiana tabacum
  (1mr4)
  
  Pentadiplandra brazzeana
  (1brz, 2brz, 2kgq, 2kyq)
  
  Defensin-like protein 1
  
  Triticum aestivum
  (1gps)
  
  Hordeum vulgare
  (1gpt)
  
  Defensin-like protein 195
  
  Arabidopsis thaliana
  (1jxc)
  
  Floral defensin-like protein 1
  
  Petunia hybrida
  (1n4n)
5. 2.4.16.12.
  Fungal defensins
  Eurocin
  
  Eurotium amstelodami
  (2lt8)
  
  Micasin
  
  Arthroderma otae
  (2lr5)
  
  Plectasin
  
  Pseudoplectania nigrella (Ebony cup)
  (3e7r, 1zfu, 3e7u)
6. 2.4.16.06.
  Myticin PF10690, PDBsum
  Mytilin-B
  
  Mytilus edulis (Blue mussel)
  (2eem)
7. 2.4.16.07.
  Diapausin PF08036, PDBsum
  Diapause-specific peptide
  
  Gastrophysa atrocyanea (Leaf beetle)
  (2e2f)
8. 2.4.16.08.
  Macin
  Hydramacin-1
  
  Hydra vulgaris
  (2k35)
9. 2.4.16.09.
  Plant self-incompatibility response protein PF06876, PDBsum
  S-locus pollen protein
  
  Brassica campestris (Field mustard)
  (1ugl)
10. 2.4.16.10.
  Prokineticin PF06607, PDBsum
  Toxin MIT1 (Black mamba intestinal toxin 1)
  
  Dendroaspis polylepis polylepis (Black mamba)
  (1imt)
11. 2.4.16.11.
  Bee venom toxins
  Tertiapin
  
  Apis mellifera
  (1ter)

2.4.16. Scorpion toxin-like knottin (11 families) CL0054, PDBsum (60 proteins)

Family	Protein Name	PDB ID	Species	Localization	Num. Subunits	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
2.4.16.04.	Defensin-like protein 1	1gpt	Hordeum vulgare	Secreted	1	3.1 ± 1.6	28 ± 18	-2.0
2.4.16.01.	Alpha-mammal toxin BmK-M8	1snb	Mesobuthus martensii (Manchurian scorpion)	Secreted	1	4.4 ± 2.4	79 ± 22	-2.3
2.4.16.01.	Neurotoxin BmK-M10	2kbk	Mesobuthus martensii (Manchurian scorpion)	Secreted	1	1.7 ± 1.0	73 ± 14	-2.4
2.4.16.04.	Defensin-like protein	1mr4	Nicotiana tabacum	Secreted	1	4.2 ± 1.8	59 ± 11	-3.0
2.4.16.02.	Defensin MGD-1	1fjn	Mytilus galloprovincialis (Mediterranean mussel)	Secreted	1	1.5 ± 1.4	43 ± 12	-3.0
2.4.16.04.	Defensin	1ti5	Vigna radiata (Mung bean)	Secreted	1	1.9 ± 2.4	62 ± 16	-3.0
2.4.16.01.	Alpha-toxin Cn12	1pe4	Centruroides noxius (Mexican scorpion)	Secreted	1	2.1 ± 2.3	17 ± 13	-3.1
2.4.16.03.	Charybdotoxin	2crd	Leiurus quinquestriatus hebraeus	Secreted	1	1.1 ± 1.5	86 ± 15	-3.2
2.4.16.06.	Mytilin-B	2eem	Mytilus edulis (Blue mussel)	Secreted	1	3.6 ± 1.4	76 ± 8	-3.2
2.4.16.02.	Termicin	1mm0	Pseudacanthotermes spiniger	Secreted	1	4.2 ± 0.5	81 ± 3	-3.3
2.4.16.01.	Alpha-insect toxin Lqq3	1lqq	Leiurus quinquestriatus quinquestriatus	Secreted	1	0.8 ± 1.0	80 ± 6	-3.3
2.4.16.01.	Alpha-mammal toxin AaH2	1aho	Androctonus australis (Sahara scorpion)	Secreted	1	1.7 ± 1.0	64 ± 17	-3.4
2.4.16.09.	S-locus pollen protein	1ugl	Brassica campestris (Field mustard)	Secreted	1	1.3 ± 0.6	51 ± 5	-3.4
2.4.16.04.	Defensin-like protein	1brz	Pentadiplandra brazzeana	Secreted	1	1.2 ± 1.2	83 ± 10	-3.6
2.4.16.01.	Toxin Bmka2	2kbj	Mesobuthus martensii (Manchurian scorpion)	Secreted	1	4.1 ± 1.5	64 ± 15	-3.6
2.4.16.01.	Beta-insect depressant toxin LqhIT2	2i61	Leiurus quinquestriatus hebraeus	Secreted	1	4.3 ± 1.6	80 ± 21	-3.7
2.4.16.01.	Toxin BmKaIT1	1omy	Mesobuthus martensii (Manchurian scorpion)	Secreted	1	4.0 ± 1.3	83 ± 10	-3.8
2.4.16.01.	Beta-mammal toxin Cn2	2yc1	Centruroides noxius (Mexican scorpion)	Secreted	1	2.8 ± 1.1	68 ± 9	-3.8
2.4.16.04.	Floral defensin-like protein 1	1n4n	Petunia hybrida	Secreted	1	1.8 ± 0.8	6 ± 9	-3.8
2.4.16.01.	Beta-toxin CsEI	1b3c	Centruroides sculpturatus (Bark scorpion)	Secreted	1	2.9 ± 1.2	70 ± 7	-3.9
2.4.16.04.	Defensin-like protein 195	1jxc	Arabidopsis thaliana	Secreted	1	4.0 ± 1.5	21 ± 20	-3.9
2.4.16.04.	Defensin-like protein 1	1gps	Triticum aestivum	Secreted	1	3.4 ± 1.3	22 ± 9	-3.9
2.4.16.02.	Defensin	2b68	Crassostrea gigas (Pacific oyster)	Secreted	1	5.8 ± 1.7	28 ± 20	-4.0
2.4.16.12.	Plectasin	3e7r	Pseudoplectania nigrella (Ebony cup)	Secreted	1	2.7 ± 2.3	53 ± 17	-4.0
2.4.16.07.	Diapause-specific peptide	2e2f	Gastrophysa atrocyanea (Leaf beetle)	Secreted	1	1.3 ± 1.0	30 ± 10	-4.2
2.4.16.01.	Alpha-toxin CsE5	1nra	Centruroides sculpturatus (Bark scorpion)	Secreted	1	2.3 ± 1.2	89 ± 22	-4.3
2.4.16.08.	Hydramacin-1	2k35	Hydra vulgaris	Secreted	1	2.0 ± 0.2	87 ± 2	-4.3
2.4.16.03.	Chlorotoxin	1chl	Leiurus quinquestriatus quinquestriatus	Secreted	1	6.5 ± 1.2	87 ± 14	-4.3
2.4.16.01.	Beta-insect excitatory toxin BmKIT1	1wwn	Mesobuthus martensii (Manchurian scorpion)	Secreted	1	4.2 ± 1.1	72 ± 6	-4.4
2.4.16.03.	Toxin I5a	1sis	Buthus eupeus	Secreted	1	3.1 ± 1.4	74 ± 16	-4.4
2.4.16.11.	Tertiapin	1ter	Apis mellifera	Secreted	1	5.1 ± 0.3	80 ± 5	-4.6
2.4.16.02.	Nasonin	2koz	Nasonia vitripennis (Parasitic wasp)	Secreted	1	2.9 ± 0.9	68 ± 7	-4.6
2.4.16.01.	Tx10 alpha-like toxin	1kv0	Buthus martensii	Secreted	1	1.9 ± 1.1	83 ± 11	-4.6
2.4.16.02.	Phormicin	1ica	Protophormia terraenovae (Northern blowfly)	Secreted	1	3.7 ± 2.3	90 ± 23	-5.0
2.4.16.03.	Potassium channel toxin alpha-KTx 3.1	3odv	Androctonus mauretanicus mauretanicus (Scorpion)	Secreted	1	2.6 ± 0.9	84 ± 5	-5.1
2.4.16.02.	Sapecin	1l4v	Sarcophaga peregrina	Secreted	1	5.4 ± 1.5	84 ± 18	-5.1
2.4.16.01.	LQH III alpha-like toxin	1fh3	Leiurus quinquestriatus hebraeus	Secreted	1	3.6 ± 1.5	83 ± 16	-5.2
2.4.16.03.	Potassium channel toxin gamma-KTx 1.1	1ne5	Centruroides noxius (Mexican scorpion)	Secreted	1	3.9 ± 1.0	62 ± 2	-5.2
2.4.16.04.	Defensin	3psm	Pachyrhizus erosus	Secreted	1	4.1 ± 1.8	32 ± 8	-5.4
2.4.16.04.	Defensin 1	1jkz	Pisum sativum	Secreted	1	3.5 ± 1.6	8 ± 19	-5.4
2.4.16.01.	Toxin CsEv3	2sn3	Centruroides sculpturatus (Bark scorpion)	Secreted	1	4.0 ± 1.3	74 ± 17	-5.5
2.4.16.12.	Eurocin	2lt8	Eurotium amstelodami	Secreted	1	5.3 ± 1.3	84 ± 12	-5.5
2.4.16.01.	Neurotoxin 2	1jza	Centruroides sculpturatus (Bark scorpion)	Secreted	1	4.0 ± 1.7	68 ± 15	-5.6
2.4.16.04.	Defensin 2 (PDF1)	2gl1	Vigna radiata (Mung bean)	Secreted	1	2.8 ± 0.6	6 ± 4	-5.7
2.4.16.01.	Alpha-like toxin CsEv5	1i6f	Centruroides sculpturatus (Bark scorpion)	Secreted	1	4.4 ± 1.3	59 ± 4	-5.8
2.4.16.01.	Kurtoxin	1t1t	Parabuthus transvaalicus	Secreted	1	3.8 ± 0.8	88 ± 11	-5.9
2.4.16.01.	Alpha-insect toxin LqhaIT	2yeo	Leiurus quinquestriatus hebraeus	Secreted	1	3.5 ± 0.8	43 ± 13	-5.9
2.4.16.02.	Drosomycin	1myn	Drosophila melanogaster	Secreted	1	4.6 ± 1.2	10 ± 17	-6.0
2.4.16.01.	Toxin VII	1npi	Tityus serrulatus	Secreted	1	4.6 ± 1.5	52 ± 16	-6.7
2.4.16.01.	Alpha-like neurotoxin BmK-I	1djt	Buthus martensii	Secreted	2	3.8 ± 0.9	90 ± 15	-6.9
2.4.16.01.	Beta-toxin Cn5	2kja	Centruroides noxius (Mexican scorpion)	Secreted	1	4.1 ± 1.1	73 ± 6	-7.0
2.4.16.02.	Defensin ARD1	1ozz	Archaeoprepona demophon	Secreted	1	4.9 ± 1.7	31 ± 17	-7.1
2.4.16.01.	Beta-insect excitatory toxin BmK IT-AP	1t0z	Mesobuthus martensii (Manchurian scorpion)	Secreted	1	3.9 ± 1.2	79 ± 10	-7.2
2.4.16.02.	Defensin	2nz3	Anopheles gambiae (African malaria mosquito)	Secreted	1	6.7 ± 1.3	84 ± 10	-7.4
2.4.16.04.	Antifungal protein 1	1ayj	Raphanus sativus	Secreted	1	11.0 ± 1.9	39 ± 19	-7.4
2.4.16.02.	Defensin heliomicin	1i2u	Heliothis virescens (Tobacco budworm moth)	Secreted	1	3.4 ± 0.4	59 ± 1	-7.6
2.4.16.01.	Toxin CsEv1	1vna	Centruroides sculpturatus (Bark scorpion)	Secreted	1	4.9 ± 1.0	65 ± 10	-7.8
2.4.16.12.	Micasin	2lr5	Arthroderma otae	Secreted	1	8.3 ± 0.6	58 ± 6	-7.8
2.4.16.01.	Neurotoxin	1dq7	Buthus tamulus	Secreted	1	5.9 ± 1.8	88 ± 18	-8.1
2.4.16.10.	Toxin MIT1 (Black mamba intestinal toxin 1)	1imt	Dendroaspis polylepis polylepis (Black mamba)	Secreted	1	4.8 ± 0.7	70 ± 3	-9.1