Superfamily » 2.2.12. Immunoglobulin-like superfamily (E set) (6 families) <a href="http://pfam.sanger.ac.uk/clan/CL0159" class="external" target="_blank">CL0159</a>, <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=CL0159" class="external" target="_blank">PDBsum</a> - Orientations of Proteins in Membranes (OPM) database

Type:2. Monotopic/peripheral (4 classes)
Class:2.2. All beta monotopic/peripheral (57 superfamilies)
Superfamily:2.2.12. Immunoglobulin-like superfamily (E set) (6 families) CL0159, PDBsum
Family:
1. 2.2.12.01.
  ML domain PF02221, PDBsum
  Epididymal secretory protein E1
  
  Bos taurus
  (1nep, 2hka)
  
  Lymphocyte antigen 86
  
  Gallus gallus
  (3mtx, 3mu3)
  
  Lymphocyte antigen 96
  
  Homo sapiens
  (2e56, 2e59, 2z65, 3fxi)
  
  Lymphocyte antigen 96, complex with Toll-like receptor 4
  
  Homo sapiens
  (2z65, 2e56, 2e59, 2z65, 3fxi)
  
  Mite group 2 allergen Der f 2
  
  Dermatophagoides farinae (American house dust mite)
  (1xwv, 1ahk, 1ahm, 1wrf, 2f08)
  
  Mite group 2 allergen Der p 2
  
  Dermatophagoides pteronyssinussearch
  (1ktj, 1a9v)
2. 2.2.12.04.
  Gamma-adaptin C-terminal appendage domain-like PF02883, PDBsum
  ADP-ribosylation factor binding protein Gga3 domain
  
  Homo sapiens
  (1p4u)
  
  ADP-ribosylation factor-binding protein GGA1
  
  Homo sapiens
  (1om9, 1j2j, 1jwf, 1jwg, 1na8, 1naf, 1nwm, 1o3x, 1oxz, 1py1, 1ujj, 1ujk, 1x79, 2dwx, 2dwy, 3g2s, 3g2t, 3g2u, 3g2v, 3g2w)
  
  AP-2 complex
  
  Rattus norvegicus
  (2vj0, 1b9k, 1ky6, 1ky7, 1kyd, 1kyf, 1kyu, 1qtp, 1qts, 1w80, 2dnr, 2jkr, 2jkt, 3hs8)
3. 2.2.12.03.
  Ganglioside GM2 activator
  Ganglioside GM2 activator
  
  Homo sapiens
  (1tjj, 1g13, 1pu5, 1pub, 2af9, 2ag2, 2ag4, 2ag9)
  
  Mus musculus
  (2agc)
  
  Ganglioside GM2 activator, apo-protein
  
  Homo sapiens
  (2ag4, 1g13, 1pu5, 1pub, 1tjj, 2ag2, 2ag9)
  
  Ganglioside GM2 activator, different conformation
  
  Homo sapiens
  (1pub, 1g13, 1pu5, 1tjj, 2af9, 2ag2, 2ag4, 2ag9)
4. 2.2.12.02.
  RHO protein GDP dissociation inhibitor PF02115, PDBsum
  Rho GDP-dissociation inhibitor 1
  
  Homo sapiens
  (1qvy, 1ajw, 1cc0, 1doa, 1fso, 1fst, 1ft0, 1ft3, 1gdf, 1hh4, 1kmt, 1rho, 2bxw)
  
  Rho GDP-dissociation inhibitor 1, complex with cell division control protein 42
  
  Homo sapiens
  (1doa, 1ajw, 1gdf)
  
  Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2
  
  Homo sapiens
  (1hh4, 1fso, 1fst, 1ft0, 1ft3, 1kmt, 1qvy, 1rho, 2bxw)
  
  Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2
  
  Homo sapiens
  (1ds6)
5. 2.2.12.05.
  Periplasmic glucan biosynthesis protein, MdoG PF04349, PDBsum
  Glucans biosynthesis protein G
  
  Escherichia coli
  (1txk)
6. 2.2.12.06.
  Immunoprotective extracellular protein PF09167, PDBsum
  Immunogenic protein MPT63
  
  Mycobacterium tuberculosis
  (1lmi)

2.2.12. Immunoglobulin-like superfamily (E set) (6 families) CL0159, PDBsum (19 proteins)

Family	Protein Name	PDB ID	Species	Localization	Num. Subunits	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
2.2.12.05.	Glucans biosynthesis protein G	1txk	Escherichia coli	Bact. Gram-neg inner	1	2.3 ± 0.7	80 ± 8	-5.1
2.2.12.02.	Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2	1ds6	Homo sapiens	Eukaryo. plasma	2	2.8 ± 1.0	82 ± 6	-5.5
2.2.12.02.	Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2	1hh4	Homo sapiens	Eukaryo. plasma	2	4.0 ± 0.6	88 ± 6	-7.2
2.2.12.02.	Rho GDP-dissociation inhibitor 1	1qvy	Homo sapiens	Eukaryo. plasma	1	2.8 ± 1.7	53 ± 19	-5.1
2.2.12.02.	Rho GDP-dissociation inhibitor 1, complex with cell division control protein 42	1doa	Homo sapiens	Eukaryo. plasma	2	1.1 ± 1.3	87 ± 4	-3.1
2.2.12.04.	ADP-ribosylation factor binding protein Gga3 domain	1p4u	Homo sapiens	Golgi	1	6.5 ± 1.1	71 ± 11	-6.5
2.2.12.04.	ADP-ribosylation factor-binding protein GGA1	1om9	Homo sapiens	Golgi	2	6.1 ± 1.0	76 ± 21	-5.1
2.2.12.03.	Ganglioside GM2 activator	1tjj	Homo sapiens	Lysosome	1	4.2 ± 0.3	57 ± 4	-8.3
2.2.12.03.	Ganglioside GM2 activator	2agc	Mus musculus	Lysosome	1	3.2 ± 1.0	54 ± 12	-5.3
2.2.12.03.	Ganglioside GM2 activator, different conformation	1pub	Homo sapiens	Lysosome	1	4.9 ± 0.7	50 ± 8	-7.3
2.2.12.03.	Ganglioside GM2 activator, apo-protein	2ag4	Homo sapiens	Lysosome	1	3.1 ± 1.3	58 ± 12	-5.4
2.2.12.01.	Epididymal secretory protein E1	1nep	Bos taurus	Secreted	1	8.0 ± 1.4	73 ± 14	-4.6
2.2.12.01.	Mite group 2 allergen Der p 2	1ktj	Dermatophagoides pteronyssinussearch	Secreted	1	1.4 ± 1.3	65 ± 9	-3.2
2.2.12.01.	Mite group 2 allergen Der f 2	1xwv	Dermatophagoides farinae (American house dust mite)	Secreted	1	1.2 ± 1.4	64 ± 10	-3.1
2.2.12.01.	Lymphocyte antigen 86	3mtx	Gallus gallus	Secreted	1	2.3 ± 1.6	69 ± 11	-2.4
2.2.12.01.	Lymphocyte antigen 96	2e56	Homo sapiens	Secreted	1	3.6 ± 0.7	68 ± 4	-6.7
2.2.12.01.	Lymphocyte antigen 96, complex with Toll-like receptor 4	2z65	Homo sapiens	Secreted	2	3.2 ± 2.0	69 ± 2	-5.7
2.2.12.06.	Immunogenic protein MPT63	1lmi	Mycobacterium tuberculosis	Secreted	1	2.2 ± 1.9	86 ± 7	-4.3
2.2.12.04.	AP-2 complex	2vj0	Rattus norvegicus	Vesicle	1	2.6 ± 2.0	80 ± 11	-4.8