Superfamily » 2.2.06. Lipocalins (2 families) <a href="http://www.tcdb.org/search/result.php?tc=8.A.33" class="external" target="_blank">8.A.33 (TCDB)</a> <a href="http://pfam.sanger.ac.uk/clan/CL0116" class="external" target="_blank">CL0116</a>, <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=CL0116" class="external" target="_blank">PDBsum</a> - Orientations of Proteins in Membranes (OPM) database

Type:2. Monotopic/peripheral (4 classes)
Class:2.2. All beta monotopic/peripheral (57 superfamilies)
Superfamily:2.2.06. Lipocalins (2 families) 8.A.33 (TCDB) CL0116, PDBsum
Family:
1. 2.2.06.01.
  Retinol binding protein-like (n=8,S=12) PF08212, PDBsum
  Allergen Bos d 2
  
  Bos taurus
  (1bj7)
  
  Apolipoprotein D
  
  Homo sapiens
  (2hzq, 2apd, 2hzr)
  
  Beta-lactoglobulin
  
  Bos taurus
  (3nq9, 1b0o, 1b8e, 1beb, 1bso, 1bsq, 1bsy, 1dv9, 1gx8, 1gx9, 1gxa, 1mfh, 1qg5, 1uz2, 2akq, 2blg, 2gj5, 2q2m, 2q2p, 2q39, 2r56, 3blg, 3hq3, 3kza, 3npo)
  
  Complement component C8 gamma chain
  
  Homo sapiens
  (1lf7, 1iw2, 2ova, 2ovd, 2ove, 2qos, 2rd7)
  
  Epididymal-specific lipocalin-5
  
  Rattus norvegicus
  (1epb, 1epa)
  
  Extracellular fatty acid-binding protein
  
  Coturnix coturnix japonica (Japanese quail)
  (2kt4, 1jzu)
  
  Neutrophil gelatinase-associated lipocalin
  
  Homo sapiens
  (3fw5, 1dfv, 1l6m, 1ngl, 1qqs, 1x71, 1x89, 1x8u, 3by0, 3cbc, 3cmp, 3dsz, 3dtq, 3fw4, 3hwd, 3hwe, 3hwf, 3hwg, 3i0a, 3k3l)
  
  Outer membrane lipoprotein Blc
  
  Escherichia coli
  (1qwd, 2aco, 3mbt, 3zvv)
  
  Prostaglandin-H2 D-isomerase
  
  Mus musculus
  (2ktd, 2czt, 2czu, 2e4j)
  
  Retinol binding protein
  
  Bos taurus
  (1kt6, 1erb, 1fel, 1fem, 1fen, 1hbp, 1hbq, 1jyd, 1jyj, 1kt3, 1kt4, 1kt5, 1kt7)
  
  Sus scrofa
  (1aqb)
  
  Homo sapiens
  (1rbp, 1brp, 1brq, 1jyd, 1jyj, 1qab, 1rlb, 2wq9, 2wqa, 2wr6, 3bsz, 3fmz)
  
  Retinol binding protein, plasma isoform
  
  Gallus gallus
  (1iiu)
2. 2.2.06.02.
  Fatty acid binding protein-like (n=10) 8.A.33 (TCDB) PF00061, PDBsum
  Adipocyte lipid-binding protein
  
  Mus musculus
  (1a18, 1a2d, 1ab0, 1acd, 1adl, 1alb, 1g74, 1g7n, 1lib, 1lic, 1lid, 1lie, 1lif, 2ans, 2q9s, 2qm9, 3hk1, 3js1, 3jsq)
  
  Homo sapiens
  (1tow, 1tou, 2hnx, 2nnq, 3fr2, 3fr4, 3fr5, 3p6c, 3p6d, 3p6e, 3p6f, 3p6g, 3p6h, 3psf, 3q6l, 3rzy)
  
  Brain fatty acid binding protein
  
  Homo sapiens
  (1fdq, 1fe3, 1jjx)
  
  Cellular retinoic acid-binding protein 1
  
  Bos taurus
  (1cbr, 1cbi)
  
  Cellular retinoic acid-binding protein 2
  
  Homo sapiens
  (1cbs, 1blr, 1bm5, 1cbq, 1xca, 2cbs, 2fr3, 2frs, 2fs6, 2fs7, 2g78, 2g79, 2g7b, 3cbs, 3cr6, 3cwk, 3d95, 3d96, 3d97, 3f8a, 3f9d, 3fa6, 3fa7, 3fa8, 3fa9, 3fek, 3fel, 3fen, 3fep, 3i17)
  
  Cellular retinol-binding protein II
  
  Rattus norvegicus
  (1crb, 1jbh, 1kgl, 1mx7, 1mx8)
  
  Danio rerio
  (1kqw, 1kqx)
  
  Cellular retinol-binding protein III
  
  Homo sapiens
  (1ggl)
  
  Der f 13 allergen
  
  Dermatophagoides farinae (American house dust mite)
  (2a0a)
  
  Epidermal fatty acid binding protein
  
  Homo sapiens
  (1b56, 1jjj)
  
  Fatty acid binding protein 6, ileal (Gastrotropin)
  
  Danio rerio
  (3elz, 3elx, 3em0)
  
  Fatty acid-binding protein
  
  Locusta migratoria (Migratory locust)
  (2flj)
  
  Schistocerca gregaria
  (1ftp)
  
  Gallus gallus
  (2k62, 1mvq, 1tvq, 1tw4, 1zry, 2jn3, 2lfo)
  
  Fatty acid-binding protein 2
  
  Ambystoma mexicanum (Axolotl)
  (2ftb, 2ft9)
  
  Fatty acid-binding protein 9
  
  Homo sapiens
  (4a60)
  
  Fatty acid-binding protein homolog 1
  
  Echinococcus granulosus
  (1o8v)
  
  Fatty acid-binding protein Sm14
  
  Schistosoma mansoni
  (1vyf, 1vyg, 2poa)
  
  Intestinal fatty acid binding protein
  
  Rattus norvegicus
  (1icm, 1a57, 1ael, 1dc9, 1icn, 1ifb, 1ifc, 1sa8, 1t8v, 1ure, 2ifb, 3akn)
  
  Homo sapiens
  (1kzw, 1kzx, 3akm, 3ifb)
  
  Muscle fatty acid binding protein
  
  Homo sapiens
  (1hmt, 1g5w, 1hmr, 1hms, 2hmb)
  
  Bos taurus
  (1bwy)
  
  Myelin P2 protein
  
  Bos taurus
  (1pmp)
  
  Homo sapiens
  (2wut, 3nr3, 4a1h, 4a1y, 4a8z)
  
  Equus caballus
  (1yiv)
  
  Prostaglandin-H2 D-isomerase
  
  Homo sapiens
  (3o22, 2wwp, 3o19, 3o2y, 4imn, 4imo)
  
  Retinoid-binding protein 7
  
  Homo sapiens
  (1lpj)
  
  Retinol-binding protein 2
  
  Rattus norvegicus
  (1opb, 1b4m, 1eii, 1opa)
  
  Homo sapiens
  (2rcq, 2rct)

2.2.06. Lipocalins (2 families) 8.A.33 (TCDB) CL0116, PDBsum (42 proteins)

Family	Protein Name	PDB ID	Species	Localization	Num. Subunits	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
2.2.06.01.	Epididymal-specific lipocalin-5	1epb	Rattus norvegicus	Secreted	1	6.4 ± 1.1	74 ± 4	-3.8
2.2.06.01.	Complement component C8 gamma chain	1lf7	Homo sapiens	Secreted	1	1.9 ± 2.2	43 ± 12	-2.6
2.2.06.01.	Retinol binding protein	1kt6	Bos taurus	Secreted	1	4.3 ± 1.7	74 ± 12	-4.7
2.2.06.01.	Retinol binding protein	1aqb	Sus scrofa	Secreted	1	4.1 ± 1.1	75 ± 14	-4.4
2.2.06.01.	Retinol binding protein	1rbp	Homo sapiens	Secreted	1	3.5 ± 0.8	70 ± 6	-5.8
2.2.06.01.	Neutrophil gelatinase-associated lipocalin	3fw5	Homo sapiens	Secreted	1	2.0 ± 1.2	45 ± 9	-3.1
2.2.06.01.	Retinol binding protein, plasma isoform	1iiu	Gallus gallus	Secreted	1	1.9 ± 1.8	35 ± 17	-4.4
2.2.06.01.	Beta-lactoglobulin	3nq9	Bos taurus	Secreted	1	0.5 ± 0.9	89 ± 4	-2.7
2.2.06.01.	Apolipoprotein D	2hzq	Homo sapiens	Secreted	1	4.5 ± 0.9	69 ± 5	-7.8
2.2.06.02.	Der f 13 allergen	2a0a	Dermatophagoides farinae (American house dust mite)	Secreted	1	3.1 ± 1.3	50 ± 6	-3.5
2.2.06.01.	Allergen Bos d 2	1bj7	Bos taurus	Secreted	1	3.1 ± 1.3	50 ± 6	-3.5
2.2.06.01.	Extracellular fatty acid-binding protein	2kt4	Coturnix coturnix japonica (Japanese quail)	Secreted	1	3.9 ± 2.9	61 ± 8	-3.4
2.2.06.02.	Cellular retinoic acid-binding protein 2	1cbs	Homo sapiens	Nuclear outer	1	7.1 ± 1.9	41 ± 13	-5.9
2.2.06.02.	Retinol-binding protein 2	1opb	Rattus norvegicus	Eukaryo. plasma	1	1.9 ± 1.4	25 ± 7	-3.6
2.2.06.02.	Fatty acid-binding protein	2flj	Locusta migratoria (Migratory locust)	Eukaryo. plasma	1	1.2 ± 1.5	62 ± 10	-3.6
2.2.06.02.	Retinol-binding protein 2	2rcq	Homo sapiens	Eukaryo. plasma	1	2.9 ± 1.7	55 ± 6	-5.5
2.2.06.02.	Muscle fatty acid binding protein	1hmt	Homo sapiens	Eukaryo. plasma	1	4.3 ± 1.6	49 ± 12	-5.0
2.2.06.02.	Muscle fatty acid binding protein	1bwy	Bos taurus	Eukaryo. plasma	1	4.8 ± 1.3	71 ± 12	-6.6
2.2.06.02.	Intestinal fatty acid binding protein	1icm	Rattus norvegicus	Eukaryo. plasma	1	3.5 ± 1.5	51 ± 18	-4.3
2.2.06.02.	Intestinal fatty acid binding protein	1kzw	Homo sapiens	Eukaryo. plasma	1	2.9 ± 1.3	61 ± 12	-4.1
2.2.06.02.	Brain fatty acid binding protein	1fdq	Homo sapiens	Eukaryo. plasma	1	3.1 ± 1.4	51 ± 15	-4.9
2.2.06.02.	Epidermal fatty acid binding protein	1b56	Homo sapiens	Eukaryo. plasma	1	2.5 ± 2.0	56 ± 18	-3.5
2.2.06.02.	Adipocyte lipid-binding protein	1a18	Mus musculus	Eukaryo. plasma	1	3.7 ± 0.8	47 ± 7	-7.4
2.2.06.02.	Adipocyte lipid-binding protein	1tow	Homo sapiens	Eukaryo. plasma	1	2.5 ± 1.7	51 ± 18	-4.5
2.2.06.02.	Fatty acid-binding protein homolog 1	1o8v	Echinococcus granulosus	Eukaryo. plasma	1	2.9 ± 1.0	48 ± 15	-5.8
2.2.06.02.	Fatty acid-binding protein	1ftp	Schistocerca gregaria	Eukaryo. plasma	1	4.5 ± 1.0	53 ± 11	-5.2
2.2.06.02.	Cellular retinoic acid-binding protein 1	1cbr	Bos taurus	Eukaryo. plasma	1	6.5 ± 1.1	45 ± 11	-5.4
2.2.06.02.	Cellular retinol-binding protein II	1crb	Rattus norvegicus	Eukaryo. plasma	1	2.4 ± 1.7	52 ± 19	-5.3
2.2.06.02.	Cellular retinol-binding protein II	1kqw	Danio rerio	Eukaryo. plasma	1	3.1 ± 1.3	45 ± 13	-4.9
2.2.06.02.	Cellular retinol-binding protein III	1ggl	Homo sapiens	Eukaryo. plasma	1	3.3 ± 1.9	53 ± 16	-4.9
2.2.06.02.	Retinoid-binding protein 7	1lpj	Homo sapiens	Eukaryo. plasma	1	2.6 ± 1.1	44 ± 13	-6.0
2.2.06.02.	Myelin P2 protein	1pmp	Bos taurus	Eukaryo. plasma	1	2.7 ± 1.3	61 ± 13	-6.1
2.2.06.02.	Fatty acid-binding protein Sm14	1vyf	Schistosoma mansoni	Eukaryo. plasma	1	5.1 ± 1.2	42 ± 18	-5.2
2.2.06.02.	Myelin P2 protein	2wut	Homo sapiens	Eukaryo. plasma	1	4.1 ± 0.5	47 ± 7	-3.4
2.2.06.02.	Myelin P2 protein	1yiv	Equus caballus	Eukaryo. plasma	1	1.3 ± 1.7	53 ± 11	-4.8
2.2.06.02.	Fatty acid-binding protein	2k62	Gallus gallus	Eukaryo. plasma	1	0.0 ± 2.9	82 ± 13	-2.0
2.2.06.02.	Fatty acid-binding protein 2	2ftb	Ambystoma mexicanum (Axolotl)	Eukaryo. plasma	1	0.6 ± 2.0	77 ± 20	-1.7
2.2.06.02.	Fatty acid-binding protein 9	4a60	Homo sapiens	Eukaryo. plasma	1	3.2 ± 1.1	38 ± 6	-4.6
2.2.06.02.	Fatty acid binding protein 6, ileal (Gastrotropin)	3elz	Danio rerio	Eukaryo. plasma	1	1.1 ± 0.9	85 ± 6	-2.4
2.2.06.02.	Prostaglandin-H2 D-isomerase	3o22	Homo sapiens	Endoplasm. reticulum	1	0.7 ± 1.2	78 ± 13	-2.4
2.2.06.01.	Prostaglandin-H2 D-isomerase	2ktd	Mus musculus	Endoplasm. reticulum	1	0.0 ± 1.4	73 ± 14	-2.2
2.2.06.01.	Outer membrane lipoprotein Blc	1qwd	Escherichia coli	Bact. Gram-neg outer	1	3.2 ± 2.0	80 ± 15	-4.6