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LIPID COMPOSITION ATLAS
Protein Classification
Types
(3 types)
Classes
(11 classes)
Superfamilies
(392 superfamilies)
Families
(667 families)
Species
(538 species)
Localization
(24 types)
All proteins in OPM
(2172 proteins)
Protein Links
PDB Sum
,
PDB
,
OCA
,
MPKS
,
PDBTM
,
MPDB
,
CGDB
Type:
1. Transmembrane
(3 classes)
Class:
1.1. Alpha-helical polytopic
(72 superfamilies)
Superfamily:
1.1.10. ABC transporters (5 families)
3.A.1 (TCDB)
Family:
1.1.10.01.
FecCD transport family
3.A.1.14 (TCDB)
PF01032
,
PDBsum
ABC transporter BtuCD, complex with BtuF, structure 1
Escherichia coli
(
2qi9
)
ABC transporter BtuCD, complex with BtuF, structure 2
Escherichia coli
(
4dbl
)
ABC transporter BtuCD, nucleotide-bound state
Escherichia coli
(
4fi3
)
ABC transporter BtuCD, symmetric structure
Escherichia coli
(
1l7v
)
ABC transporter permease HI1471
Haemophilus influenzae
(
2nq2
)
Hemin transport system permease, HmuU
Yersinia pestis
(
4g1u
)
1.1.10.02.
Binding-protein-dependent transport system
3.A.1.1 (TCDB)
PF00528
,
PDBsum
Maltose transporter MalFGK, a pre-translocation state
Escherichia coli
(
3puz
, 3pv0)
Maltose transporter MalFGK, inward conformation, TMH 1 deleted
Escherichia coli
(
3fh6
)
Maltose transporter MalFGK, outward conformation
Escherichia coli
(
3puw
, 2r6g, 3puv, 3pux, 3puy, 3rlf)
Methionine importer MetNI, conformation 1
Escherichia coli
(
3tui
, 3tuz)
Methionine importer MetNI, conformation 2
Escherichia coli
(
3tuj
)
Methionine importer MetNI, conformation 3
Escherichia coli
(
3dhw
)
Molybdate transporter ModBC, open state
Methanosarcina acetivorans
(
3d31
)
Archaeoglobus fulgidus
(
2onk
)
1.1.10.03.
Lipid/drug exporters
3.A.1.106 (TCDB)
PF00664
,
PDBsum
ABC transporter, inward-facing conformation
Thermotoga maritima
(
3qf4
)
Lipid flippase MsbA, closed state
Vibrio cholerae
(
3b5x
)
Lipid flippase MsbA, open state
Salmonella enterica
(
3b60
, 3b5w, 3b5x, 3b5y, 3b5z)
Multidrug ABC transporter SAV1866, closed state
Staphylococcus aureus
(
2hyd
, 2onj, 4a82)
1.1.10.04.
Multidrug resistance exporter (MDR)
3.A.1.201 (TCDB)
PF00664
,
PDBsum
Multidrug resistance protein pgp-1
Caenorhabditis elegans
(
4f4c
)
P-glycoprotein, inward-facing conformation
Mus musculus
(
3g5u
, 3g60, 3g61)
1.1.10.05.
Mitochondrial peptide exporter family (ABCB)
3.A.1.212 (TCDB)
PF00664
,
PDBsum
Mitochondrial ABC transporter ABCB10, conformation 1
Homo sapiens
(
4ayt
)
Mitochondrial ABC transporter ABCB10, conformation 2
Homo sapiens
(
4ayw
)
Mitochondrial ABC transporter ABCB10, conformation 3
Homo sapiens
(
4ayx
)
Mitochondrial ABC transporter ABCB10, conformation 4
Homo sapiens
(
3zdq
)
See list of these PDB codes
1.1.10. ABC transporters (5 families)
3.A.1 (TCDB)
(24 proteins)
Family
Protein Name
PDB ID
Species
Localization
Num. Subunits
Num. TM Sec. Structs.
Hydrophobic Thickness or Depth (Å)
Tilt Angle (°)
ΔG
transfer
(kcal/mol)
1.1.10.01.
Hemin transport system permease, HmuU
4g1u
Yersinia pestis
Bact. Gram-neg inner
2
20
29.8 ± 0.5
0 ± 0
-114.3
1.1.10.01.
ABC transporter BtuCD, nucleotide-bound state
4fi3
Escherichia coli
Bact. Gram-neg inner
2
20
29.0 ± 1.0
0 ± 0
-118.3
1.1.10.04.
Multidrug resistance protein pgp-1
4f4c
Caenorhabditis elegans
Eukaryo. plasma
1
14
32.0 ± 1.8
6 ± 0
-105.1
1.1.10.01.
ABC transporter BtuCD, complex with BtuF, structure 2
4dbl
Escherichia coli
Bact. Gram-neg inner
2
20
29.4 ± 1.0
4 ± 0
-123.4
1.1.10.05.
Mitochondrial ABC transporter ABCB10, conformation 3
4ayx
Homo sapiens
Mitochon. inner
2
12
30.0 ± 0.6
0 ± 0
-76.8
1.1.10.05.
Mitochondrial ABC transporter ABCB10, conformation 2
4ayw
Homo sapiens
Mitochon. inner
2
12
29.0 ± 0.8
0 ± 0
-65.8
1.1.10.05.
Mitochondrial ABC transporter ABCB10, conformation 1
4ayt
Homo sapiens
Mitochon. inner
2
12
30.4 ± 0.8
0 ± 0
-79.7
1.1.10.05.
Mitochondrial ABC transporter ABCB10, conformation 4
3zdq
Homo sapiens
Mitochon. inner
2
12
30.8 ± 0.5
1 ± 0
-71.8
1.1.10.02.
Methionine importer MetNI, conformation 2
3tuj
Escherichia coli
Bact. Gram-neg inner
2
10
30.4 ± 1.3
7 ± 1
-84.5
1.1.10.02.
Methionine importer MetNI, conformation 1
3tui
Escherichia coli
Bact. Gram-neg inner
2
10
30.2 ± 1.3
1 ± 1
-81.0
1.1.10.03.
ABC transporter, inward-facing conformation
3qf4
Thermotoga maritima
Bact. Gram-neg inner
2
12
32.0 ± 0.8
2 ± 0
-104.9
1.1.10.02.
Maltose transporter MalFGK, a pre-translocation state
3puz
Escherichia coli
Bact. Gram-neg inner
2
14
29.0 ± 0.8
7 ± 0
-107.2
1.1.10.02.
Maltose transporter MalFGK, outward conformation
3puw
Escherichia coli
Bact. Gram-neg inner
2
14
29.8 ± 1.3
3 ± 1
-94.0
1.1.10.04.
P-glycoprotein, inward-facing conformation
3g5u
Mus musculus
Eukaryo. plasma
1
12
31.8 ± 1.2
4 ± 0
-100.6
1.1.10.02.
Maltose transporter MalFGK, inward conformation, TMH 1 deleted
3fh6
Escherichia coli
Bact. Gram-neg inner
2
13
29.9 ± 0.6
3 ± 1
-97.8
1.1.10.02.
Methionine importer MetNI, conformation 3
3dhw
Escherichia coli
Bact. Gram-neg inner
2
10
29.2 ± 1.0
1 ± 0
-82.5
1.1.10.02.
Molybdate transporter ModBC, open state
3d31
Methanosarcina acetivorans
Archaebac.
2
12
29.8 ± 1.5
1 ± 0
-91.6
1.1.10.03.
Lipid flippase MsbA, open state
3b60
Salmonella enterica
Bact. Gram-neg inner
2
12
31.8 ± 0.9
0 ± 0
-98.5
1.1.10.03.
Lipid flippase MsbA, closed state
3b5x
Vibrio cholerae
Bact. Gram-neg inner
2
12
30.2 ± 1.0
0 ± 0
-58.7
1.1.10.01.
ABC transporter BtuCD, complex with BtuF, structure 1
2qi9
Escherichia coli
Bact. Gram-neg inner
2
22
29.4 ± 0.9
4 ± 4
-123.5
1.1.10.02.
Molybdate transporter ModBC, open state
2onk
Archaeoglobus fulgidus
Archaebac.
2
12
32.0 ± 1.7
0 ± 1
-100.7
1.1.10.01.
ABC transporter permease HI1471
2nq2
Haemophilus influenzae
Bact. Gram-neg inner
2
20
31.9 ± 0.9
1 ± 1
-124.2
1.1.10.03.
Multidrug ABC transporter SAV1866, closed state
2hyd
Staphylococcus aureus
Bact. Gram-pos plas.
2
12
31.8 ± 1.7
3 ± 3
-110.5
1.1.10.01.
ABC transporter BtuCD, symmetric structure
1l7v
Escherichia coli
Bact. Gram-neg inner
2
22
30.7 ± 1.1
0 ± 1
-121.0
Copyright © 2005-2013
Andrei Lomize
,
Mikhail Lomize
and
Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA