Superfamily » 1.2.33. Transmembrane proteins with NAD(P)-binding Rossmann-fold domains (2 families) <a href="http://pfam.sanger.ac.uk/clan/CL0063" class="external" target="_blank">CL0063</a>, <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=CL0063" class="external" target="_blank">PDBsum</a> - Orientations of Proteins in Membranes (OPM) database

Type:1. Transmembrane (3 classes)
Class:1.2. Alpha-helical bitopic (42 superfamilies)
Superfamily:1.2.33. Transmembrane proteins with NAD(P)-binding Rossmann-fold domains (2 families) CL0063, PDBsum
Family:
1. 2.3.04.01.
  Tyrosine-dependent oxidoreductases PF00106, PDBsum
  Corticosteroid 11-beta-dehydrogenase, isozyme 1
  
  Mus musculus
  (1y5m, 1y5r, 3gmd)
  
  Homo sapiens
  (1xu7, 1xu9, 2bel, 2ilt, 2irw, 2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3fco, 3frj, 3h6k, 3hfg, 3oq1, 3qqp, 3tfq, 4bb5, 4bb6, 4hfr)
  
  Cavia porcellus
  (3g49, 1xse, 3dwf)
  
  Pteridine reductase 1
  
  Leishmania tarentolae (Sauroleishmania tarentolae)
  (1p33)
  
  Sorbitol dehydrogenase
  
  Rhodobacter sphaeroides
  (1k2w, 1uzo)
  
  Tropinone reductase 2
  
  Datura stramonium (Jimsonweed)
  (1ipe, 1ipf, 2ae1, 2ae2)
2. 1.2.33.02.
  Flavin containing amine oxidoreductase PF01593, PDBsum
  Alpha-glycerophosphate oxidase (GlpO)
  
  Streptomyces sp.
  (2rgh, 2rgo)
  
  Monoamine oxidase A
  
  Rattus norvegicus
  (1o5w)
  
  Homo sapiens
  (2z5x, 2bxr, 2bxs, 2z5y)
  
  Monoamine oxidase B, dimer
  
  Homo sapiens
  (2xfn, 1s3e)
  
  Monoamine oxidase B, monomer
  
  Homo sapiens
  (1s3e, 1gos, 1oj9, 1oja, 1ojc, 1ojd, 1s2q, 1s2y, 1s3b, 2bk3, 2bk4, 2bk5, 2byb, 2c64, 2c65, 2c66, 2c67, 2c70, 2c72, 2c73, 2c75, 2c76, 2v5z, 2v60, 2v61, 2vrl, 2vrm, 2vz2, 2xcg, 2xfn, 2xfo, 2xfp, 2xfq, 2xfu, 3po7, 3zyx, 4a79, 4a7a)
  
  Protoporphyrinogen oxidase
  
  Nicotiana tabacum
  (1sez)
  
  Homo sapiens
  (3nks, 4ivm, 4ivo)
  
  Myxococcus xanthus
  (2ivd, 2ive)

1.2.33. Transmembrane proteins with NAD(P)-binding Rossmann-fold domains (2 families) CL0063, PDBsum (14 proteins)

Family	Protein Name	PDB ID	Species	Localization	Num. Subunits	Num. TM Sec. Structs.	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
2.3.04.01.	Corticosteroid 11-beta-dehydrogenase, isozyme 1	3g49	Cavia porcellus	Endoplasm. reticulum	2	0	7.0 ± 0.5	90 ± 1	-15.9
2.3.04.01.	Tropinone reductase 2	1ipe	Datura stramonium (Jimsonweed)	Eukaryo. plasma	7	0	3.3 ± 0.7	77 ± 4	-8.8
1.2.33.02.	Monoamine oxidase B, monomer	1s3e	Homo sapiens	Mitochon. outer	2	0	7.3 ± 0.6	37 ± 1	-14.2
1.2.33.02.	Monoamine oxidase B, dimer	2xfn	Homo sapiens	Mitochon. outer	2	2	30.0 ± 3.2	14 ± 0	-14.5
1.2.33.02.	Protoporphyrinogen oxidase	3nks	Homo sapiens	Mitochon. inner	1	0	4.8 ± 1.0	59 ± 3	-9.6
1.2.33.02.	Monoamine oxidase A	2z5x	Homo sapiens	Mitochon. outer	1	1	31.0 ± 2.1	17 ± 1	-21.4
2.3.04.01.	Corticosteroid 11-beta-dehydrogenase, isozyme 1	1xu7	Homo sapiens	Endoplasm. reticulum	2	0	7.9 ± 0.2	89 ± 1	-20.2
2.3.04.01.	Pteridine reductase 1	1p33	Leishmania tarentolae (Sauroleishmania tarentolae)	Eukaryo. plasma	4	0	3.4 ± 1.0	73 ± 13	-7.7
2.3.04.01.	Corticosteroid 11-beta-dehydrogenase, isozyme 1	1y5m	Mus musculus	Endoplasm. reticulum	2	0	4.6 ± 0.4	89 ± 2	-19.3
1.2.33.02.	Protoporphyrinogen oxidase	2ivd	Myxococcus xanthus	Bact. Gram-neg inner	1	0	3.7 ± 0.2	29 ± 2	-8.0
1.2.33.02.	Protoporphyrinogen oxidase	1sez	Nicotiana tabacum	Mitochon. inner	1	0	2.2 ± 1.0	50 ± 3	-7.0
1.2.33.02.	Monoamine oxidase A	1o5w	Rattus norvegicus	Mitochon. outer	2	2	31.4 ± 3.4	20 ± 3	-23.1
2.3.04.01.	Sorbitol dehydrogenase	1k2w	Rhodobacter sphaeroides	Bact. Gram-neg inner	2	0	2.2 ± 0.3	89 ± 1	-4.4
1.2.33.02.	Alpha-glycerophosphate oxidase (GlpO)	2rgh	Streptomyces sp.	Bact. Gram-pos plas.	1	0	3.9 ± 1.4	71 ± 12	-6.2