Family » 3.2.08.01. Beta-sheet peptides of amyloid beta A4 protein <a href="http://pfam.sanger.ac.uk/family/PF03494" class="external" target="_blank">PF03494</a>, <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF03494" class="external" target="_blank">PDBsum</a> - Orientations of Proteins in Membranes (OPM) database

Type:3. Peptides (4 classes)
Class:3.2. Beta-hairpin peptides (9 superfamilies)
Superfamily:3.2.08. Amyloid beta-sheet peptides (2 families)
Family:
3.2.08.01. Beta-sheet peptides of amyloid beta A4 protein PF03494, PDBsum

Amyloid beta A4 protein, peptide 672-711

Homo sapiens (2lnq)

Peptide 30-35

Homo sapiens (2y3j, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3k, 2y3l, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj, 3ow9)

Peptide 35-42, alternate polymorph I

Homo sapiens (2y3k, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3j, 2y3l, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj, 3ow9)

Peptide 35-42, alternate polymorph II

Homo sapiens (2y3l, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3j, 2y3k, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj, 3ow9)

Peptide KLVFFA from amyloid beta, alternate polymorph II

Homo sapiens (3ow9, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3j, 2y3k, 2y3l, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj)

3.2.08.01. Beta-sheet peptides of amyloid beta A4 protein PF03494, PDBsum (5 proteins)

Protein Name	PDB ID	Species	Localization	Num. Subunits	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
Peptide 35-42, alternate polymorph I	2y3k	Homo sapiens	Secreted	2	3.4 ± 1.4	89 ± 4	-7.2
Peptide 30-35	2y3j	Homo sapiens	Secreted	4	4.0 ± 1.4	86 ± 6	-6.2
Peptide 35-42, alternate polymorph II	2y3l	Homo sapiens	Secreted	4	2.7 ± 1.4	78 ± 8	-6.0
Amyloid beta A4 protein, peptide 672-711	2lnq	Homo sapiens	Eukaryo. plasma	8	6.3 ± 2.0	88 ± 0	-15.5
Peptide KLVFFA from amyloid beta, alternate polymorph II	3ow9	Homo sapiens	Secreted	12	4.1 ± 1.4	88 ± 7	-12.8