- Type:1. Transmembrane (2 classes)
- Class:1.1. Alpha-helical transmembrane (54 superfamilies)
- Superfamily:1.1.45. Viral channel proteins (1 family) 1.A.19 (TCDB)
- Family:
- 1.1.45.01.Influenza virus matrix protein 2 1.A.19 (TCDB)
M2 transmembrane domain tetramer, closed state
M2 transmembrane domain tetramer, open state, complex with amantadine
M2 transmembrane domain tetramer, open state, ligand-free
1.1.45. Viral channel proteins (1 family) 1.A.19 (TCDB) (3 proteins)
| Family | Protein Name | PDB ID | Species | Localization | Num. Subunits | Num. TM Sec. Structs. | Hydrophobic Thickness or Depth (Å) | Tilt Angle (°) | ΔGtransfer (kcal/mol) |
|---|---|---|---|---|---|---|---|---|---|
| 1.1.45.01. | M2 transmembrane domain tetramer, open state, ligand-free | 3bkd | Influenza virus | Viral | 4 | 4 | 24.8 ± 1.4 | 1 ± 3 | -69.3 |
| 1.1.45.01. | M2 transmembrane domain tetramer, open state, complex with amantadine | 3c9j | Influenza virus | Viral | 4 | 4 | 25.0 ± 1.0 | 7 ± 4 | -76.5 |
| 1.1.45.01. | M2 transmembrane domain tetramer, closed state | 2rlf | Influenza virus | Viral | 4 | 4 | 31.4 ± 1.8 | 4 ± 7 | -79.3 |
