Superfamily » 3.2.08. Amyloid beta-sheet peptides (2 families) - Orientations of Proteins in Membranes (OPM) database

Type:3. Peptides (4 classes)
Class:3.2. Beta-hairpin peptides (9 superfamilies)
Superfamily:3.2.08. Amyloid beta-sheet peptides (2 families)
Family:
1. 3.2.08.01.
  Beta-sheet peptides of amyloid beta A4 protein PF03494, PDBsum
  Amyloid beta A4 protein, peptide 672-711
  
  Homo sapiens
  (2lnq)
  
  Peptide 30-35
  
  Homo sapiens
  (2y3j, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3k, 2y3l, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj, 3ow9)
  
  Peptide 35-42, alternate polymorph I
  
  Homo sapiens
  (2y3k, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3j, 2y3l, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj, 3ow9)
  
  Peptide 35-42, alternate polymorph II
  
  Homo sapiens
  (2y3l, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3j, 2y3k, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj, 3ow9)
  
  Peptide KLVFFA from amyloid beta, alternate polymorph II
  
  Homo sapiens
  (3ow9, 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1bjb, 1bjc, 1brc, 1ca0, 1hz3, 1iyt, 1mwp, 1owt, 1qcm, 1qwp, 1qxc, 1qyt, 1taw, 1tkn, 1uo7, 1uo8, 1uoa, 1uoi, 1x11, 1z0q, 1ze7, 1ze9, 1zjd, 2beg, 2bom, 2bp4, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47, 2ipu, 2lfm, 2otk, 2r0w, 2wk3, 2y29, 2y2a, 2y3j, 2y3k, 2y3l, 3ayu, 3dxc, 3dxd, 3dxe, 3gci, 3ifl, 3ifn, 3ifo, 3ifp, 3jti, 3ktm, 3l33, 3l81, 3moq, 3mxc, 3mxy, 3nyj, 3nyl, 3ovj)
2. 3.2.08.02.
  Beta-sheet peptides of major prion protein PF00377, PDBsum
  Major prion protein, peptide 138-143
  
  Mesocricetus auratus (Golden hamster)
  (3nve, 1b10, 2kkg, 2lh8)
  
  Homo sapiens
  (3nvf, 1e1g, 1e1j, 1e1p, 1e1s, 1e1u, 1e1w, 1fkc, 1fo7, 1h0l, 1hjm, 1hjn, 1i4m, 1oeh, 1oei, 1qlx, 1qlz, 1qm0, 1qm1, 1qm2, 1qm3, 2iv4, 2iv5, 2iv6, 2k1d, 2kun, 2lej, 2ol9, 2w9e, 3haf, 3hak, 3heq, 3her, 3hes, 3hj5, 3hjx, 3md4, 3md5, 3nhc, 3nhd)

3.2.08. Amyloid beta-sheet peptides (2 families) (7 proteins)

Family	Protein Name	PDB ID	Species	Localization	Num. Subunits	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
3.2.08.01.	Amyloid beta A4 protein, peptide 672-711	2lnq	Homo sapiens	Eukaryo. plasma	8	6.3 ± 2.0	88 ± 0	-15.5
3.2.08.01.	Peptide 30-35	2y3j	Homo sapiens	Secreted	4	4.0 ± 1.4	86 ± 6	-6.2
3.2.08.01.	Peptide 35-42, alternate polymorph I	2y3k	Homo sapiens	Secreted	2	3.4 ± 1.4	89 ± 4	-7.2
3.2.08.01.	Peptide 35-42, alternate polymorph II	2y3l	Homo sapiens	Secreted	4	2.7 ± 1.4	78 ± 8	-6.0
3.2.08.01.	Peptide KLVFFA from amyloid beta, alternate polymorph II	3ow9	Homo sapiens	Secreted	12	4.1 ± 1.4	88 ± 7	-12.8
3.2.08.02.	Major prion protein, peptide 138-143	3nve	Mesocricetus auratus (Golden hamster)	Eukaryo. plasma	12	3.6 ± 0.4	89 ± 3	-9.8
3.2.08.02.	Major prion protein, peptide 138-143	3nvf	Homo sapiens	Eukaryo. plasma	10	6.9 ± 0.2	83 ± 2	-9.8