PDB ID or protein name
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1.2.32. Cytochrome P450 (1 family) PF00067, PDBsum (58 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
1.2.32.01. Cytochrome P450 2C5 1nr6 Oryctolagus cuniculus Endoplasm. reticulum 1 0 10.6 ± 1.0 54 ± 18 -9.1
1.2.32.01. Cytochrome P450 2B4, closed state 1 1suo Oryctolagus cuniculus Endoplasm. reticulum 1 0 4.6 ± 1.3 57 ± 4 -14.2
1.2.32.01. Cytochrome P450 2C8 1pq2 Homo sapiens Endoplasm. reticulum 1 0 3.8 ± 1.8 65 ± 9 -8.6
1.2.32.01. Cytochrome P450 2C9 1og5 Homo sapiens Endoplasm. reticulum 1 0 7.6 ± 1.0 79 ± 6 -13.7
1.2.32.01. Cytochrome P450 3A4, conformation 1 1tqn Homo sapiens Endoplasm. reticulum 1 0 8.7 ± 1.0 67 ± 11 -18.5
1.2.32.01. Cytochrome P450 2A6 1z10 Homo sapiens Endoplasm. reticulum 1 0 5.0 ± 1.7 44 ± 18 -9.5
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 2 2wx2 Trypanosoma cruzi Endoplasm. reticulum 1 0 5.9 ± 5.9 63 ± 2 -6.2
1.2.32.01. Cytochrome P450 2B4, open state 2 1po5 Oryctolagus cuniculus Endoplasm. reticulum 1 0 3.5 ± 1.4 79 ± 9 -7.2
1.2.32.01. Cholesterol 7-alpha-monooxygenase (P450 7A1), different conformation 3sn5 Homo sapiens Endoplasm. reticulum 1 0 6.0 ± 1.9 73 ± 4 -6.5
1.2.32.01. Cytochrome P450 2D6, conformation 1 2f9q Homo sapiens Endoplasm. reticulum 1 0 7.0 ± 1.8 29 ± 10 -12.0
1.2.32.01. Cytochrome P450 2B4, open state 1 2bdm Oryctolagus cuniculus Endoplasm. reticulum 1 0 10.6 ± 1.0 48 ± 15 -16.2
1.2.32.01. Cytochrome P450 2C9, different conformation 1r9o Homo sapiens Endoplasm. reticulum 1 0 4.0 ± 1.1 59 ± 8 -10.1
1.2.32.01. Cytochrome P450 2C5, different conformation 1dt6 Oryctolagus cuniculus Endoplasm. reticulum 1 0 7.3 ± 1.0 13 ± 7 -8.8
1.2.32.01. Cytochrome P450 1A2 2hi4 Homo sapiens Endoplasm. reticulum 1 0 6.9 ± 1.0 66 ± 9 -16.2
1.2.32.01. Prostacyclin synthase (cytochrome P450 8A1) 3b6h Homo sapiens Endoplasm. reticulum 1 0 5.0 ± 1.6 64 ± 18 -6.3
1.2.32.01. Cytochrome P450 2E1 3e6i Homo sapiens Endoplasm. reticulum 1 0 8.3 ± 2.0 49 ± 8 -14.2
1.2.32.01. Cytochrome P450 2R1 3czh Homo sapiens Endoplasm. reticulum 1 0 8.3 ± 1.5 48 ± 13 -13.2
1.2.32.01. Plant cytochrome P450 74A (allene oxide synthase) 3dan Parthenium argentatum Vacuole 1 0 7.5 ± 0.4 64 ± 2 -24.1
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 1 2q9f Homo sapiens Endoplasm. reticulum 1 0 2.8 ± 1.0 86 ± 7 -5.8
1.2.32.01. Cytochrome P450 19A1 (aromatase, estrogen synthetase) 3eqm Homo sapiens Endoplasm. reticulum 1 0 6.1 ± 1.2 58 ± 8 -12.4
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3ld6 Homo sapiens Endoplasm. reticulum 1 0 8.9 ± 0.6 57 ± 2 -16.8
1.2.32.01. Cytochrome P450 120a1, different conformation 2ve3 Synechocystis sp. Thylakoid 1 0 5.2 ± 1.5 52 ± 15 -6.8
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3g1q Trypanosoma brucei Endoplasm. reticulum 1 0 8.1 ± 1.5 62 ± 12 -10.8
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 1 2wuz Trypanosoma cruzi Endoplasm. reticulum 1 0 4.0 ± 1.1 75 ± 11 -9.9
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3l4d Leishmania infantum Endoplasm. reticulum 1 0 8.4 ± 1.8 66 ± 9 -12.6
1.2.32.01. Cytochrome P450 24a1 (1,25-dihydroxyvitamin D(3) 24-hydroxylase) 3k9v Rattus norvegicus Mitochon. inner 1 0 6.6 ± 1.0 49 ± 6 -9.6
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 2 3mdm Homo sapiens Endoplasm. reticulum 1 0 3.8 ± 1.3 51 ± 8 -5.9
1.2.32.01. Cytochrome P450 3A4, conformation 2 3nxu Homo sapiens Endoplasm. reticulum 1 0 9.3 ± 1.0 52 ± 12 -17.5
1.2.32.01. Cholesterol side-chain cleavage enzyme (P450 11A1), complex with adrenodoxin 3n9y Homo sapiens Mitochon. inner 1 0 4.1 ± 0.6 49 ± 5 -6.2
1.2.32.01. Cytochrome P450 2B6, conformation 1 3ibd Homo sapiens Endoplasm. reticulum 1 0 4.7 ± 1.0 57 ± 3 -10.8
1.2.32.01. Cholesterol 7-alpha-monooxygenase (P450 7A1) 3dax Homo sapiens Endoplasm. reticulum 1 0 1.8 ± 1.9 69 ± 8 -3.9
1.2.32.01. Cholesterol side-chain cleavage enzyme (P450 11A1) 3mzs Bos taurus Mitochon. inner 1 0 3.2 ± 0.3 33 ± 1 -6.7
1.2.32.01. Cytochrome P450 1B1 3pm0 Homo sapiens Endoplasm. reticulum 1 0 3.8 ± 0.7 79 ± 1 -7.0
1.2.32.01. Cytochrome P450 2A13 2p85 Homo sapiens Endoplasm. reticulum 1 0 4.9 ± 0.4 47 ± 2 -10.0
1.2.32.01. Cytochrome P450 2B4, open state 3 3r1b Oryctolagus cuniculus Endoplasm. reticulum 1 0 5.7 ± 0.0 43 ± 5 -9.8
1.2.32.01. Steroid 17-alpha-hydroxylase/17,20 lyase (P450 17A1) 3swz Homo sapiens Endoplasm. reticulum 1 0 4.2 ± 1.6 56 ± 3 -8.4
1.2.32.01. Fatty-acid peroxygenase 1izo Bacillus subtilis Bact. Gram-pos plas. 1 0 1.2 ± 0.3 76 ± 1 -5.5
1.2.32.01. Cytochrome P450 1n97 Thermus thermophilus Bact. Gram-neg inner 1 0 5.2 ± 0.3 43 ± 5 -9.9
1.2.32.01. Plant cytochrome P450 74A (allene oxide synthase) 3dsk Arabidopsis thaliana Thylakoid 1 0 5.7 ± 0.5 67 ± 3 -20.0
1.2.32.01. Steroid 21-hydroxylase (P450 C21) 3qz1 Bos taurus Endoplasm. reticulum 1 0 5.9 ± 1.6 72 ± 3 -10.4
1.2.32.01. Cytochrome P450 2D6, conformation 3 3qm4 Homo sapiens Endoplasm. reticulum 1 0 9.0 ± 1.4 35 ± 11 -9.3
1.2.32.01. Cytochrome P450 2D6, conformation 2 3tda Homo sapiens Endoplasm. reticulum 1 0 8.0 ± 0.7 35 ± 7 -12.5
1.2.32.01. Cytochrome P450 2B6, conformation 2 3ua5 Homo sapiens Endoplasm. reticulum 1 0 4.7 ± 1.1 55 ± 3 -12.9
1.2.32.01. Cytochrome P450 11B2, mitochondrial 4dvq Homo sapiens Mitochon. inner 1 0 4.8 ± 0.6 48 ± 4 -9.1
1.2.32.01. Cytochrome P450 1A1 4i8v Homo sapiens Endoplasm. reticulum 1 0 7.1 ± 1.0 64 ± 3 -15.1
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 3 3ksw Trypanosoma cruzi Endoplasm. reticulum 1 0 8.0 ± 6.7 61 ± 6 -9.1
1.2.32.01. Cytochrome P450 2B4, closed state 2 2q6n Oryctolagus cuniculus Endoplasm. reticulum 1 0 5.5 ± 0.4 55 ± 2 -13.0
1.2.32.01. Cytochrome P450 2B4, closed state 3 3g5n Oryctolagus cuniculus Endoplasm. reticulum 1 0 5.7 ± 1.8 65 ± 3 -12.1
1.2.32.01. Cytochrome P450 120a1 2ve4 Synechocystis sp. Thylakoid 1 0 6.3 ± 0.9 47 ± 8 -8.6
1.2.32.01. Cytochrome P450 2B6, conformation 3 4i91 Homo sapiens Endoplasm. reticulum 1 0 4.7 ± 2.9 59 ± 11 -11.3
1.2.32.01. Prostaglandin I2 synthase 3b98 Danio rerio Endoplasm. reticulum 1 0 4.4 ± 1.3 65 ± 6 -4.7
1.2.32.01. Cytochrome P450 2C19 4gqs Homo sapiens Archaebac. 1 0 6.4 ± 2.1 71 ± 5 -9.5
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 4 3zg2 Trypanosoma cruzi Endoplasm. reticulum 1 0 5.8 ± 1.0 62 ± 4 -9.0
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 3 4j14 Homo sapiens Endoplasm. reticulum 1 0 3.4 ± 1.4 35 ± 19 -4.0
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 5 4by0 Trypanosoma cruzi Eukaryo. plasma 1 0 4.8 ± 2.6 88 ± 7 -1.6
1.2.32.01. Lanosterol 14-alpha demethylase (CYP51) 4lxj Saccharomyces cerevisiae Endoplasm. reticulum 1 1 29.8 ± 0.6 41 ± 0 -32.2
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 6 4coh Trypanosoma cruzi Endoplasm. reticulum 1 0 6.3 ± 1.3 56 ± 6 -7.3
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 7 4bmm Trypanosoma cruzi Endoplasm. reticulum 1 0 8.8 ± 3.3 36 ± 30 -10.9