Superfamily » 1.2.22. Bcl-2 inhibitors of programmed cell death (1 family) <a href="http://www.tcdb.org/search/result.php?tc=1.A.21" class="external" target="_blank">1.A.21 (TCDB)</a> <a href="http://pfam.sanger.ac.uk/family/PF00452" class="external" target="_blank">PF00452</a>, <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF00452" class="external" target="_blank">PDBsum</a> - Orientations of Proteins in Membranes (OPM) database

Type:1. Transmembrane (3 classes)
Class:1.2. Alpha-helical bitopic (42 superfamilies)
Superfamily:1.2.22. Bcl-2 inhibitors of programmed cell death (1 family) 1.A.21 (TCDB) PF00452, PDBsum
Family:
1. 1.2.22.01.
  Bcl-2 inhibitors of programmed cell death 1.A.21 (TCDB) PF00452, PDBsum
  Activator of apoptosis harakiri, cytosolic helix
  
  Homo sapiens
  (2l58, 2l5b)
  
  Activator of apoptosis harakiri, transmembrane helix
  
  Homo sapiens
  (2l5b, 2l58)
  
  Apoptosis regulator Bcl-2
  
  Homo sapiens
  (1g5m, 1gjh, 1ysw)
  
  Bcl-2-like protein 1, complex with alpha-beta-foldamer
  
  Homo sapiens
  (4a1u, 1bxl, 1g5j, 1lxl, 1maz, 1r2d, 1r2e, 1r2g, 1r2h, 1r2i, 1ysg, 1ysi, 1ysn, 2b48, 2o1y, 2o2m, 2o2n, 2p1l, 2pon, 2yj1, 2yxj, 3cva, 3fdl, 3fdm, 3inq, 3io8, 3pl7, 3qkd, 3r85)

1.2.22. Bcl-2 inhibitors of programmed cell death (1 family) 1.A.21 (TCDB) PF00452, PDBsum (4 proteins)

Family	Protein Name	PDB ID	Species	Localization	Num. Subunits	Num. TM Sec. Structs.	Hydrophobic Thickness or Depth (Å)	Tilt Angle (°)	ΔG_transfer (kcal/mol)
1.2.22.01.	Apoptosis regulator Bcl-2	1g5m	Homo sapiens	Mitochon. outer	1	0	4.2 ± 1.4	33 ± 11	-6.6
1.2.22.01.	Activator of apoptosis harakiri, transmembrane helix	2l5b	Homo sapiens	Mitochon. outer	1	1	29.8 ± 0.9	14 ± 11	-11.9
1.2.22.01.	Activator of apoptosis harakiri, cytosolic helix	2l58	Homo sapiens	Mitochon. outer	1	0	2.4 ± 4.0	88 ± 0	-8.5
1.2.22.01.	Bcl-2-like protein 1, complex with alpha-beta-foldamer	4a1u	Homo sapiens	Mitochon. outer	1	0	5.8 ± 0.3	26 ± 5	-5.7