PDB ID or protein name

Endoplasmic reticulum membrane (125 proteins)

Family Protein Name PDB ID Species Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
1.1.09.01. Calcium ATPase, E2 state, Ca-free, conformation 3 2ear Oryctolagus cuniculus 1 10 30.0 ± 1.2 19 ± 1 -58.4
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 4 3b9r Oryctolagus cuniculus 1 10 26.8 ± 0.0 25 ± 0 -44.1
1.1.09.01. Calcium ATPase, E1-2Ca state, conformation 3 1su4 Oryctolagus cuniculus 1 10 30.0 ± 2.7 26 ± 1 -68.6
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 2 2by4 Oryctolagus cuniculus 1 10 29.8 ± 1.3 24 ± 1 -63.7
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 3 3b9b Oryctolagus cuniculus 1 10 29.9 ± 1.6 16 ± 2 -58.1
1.1.09.01. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 3tlm Bos taurus 1 10 26.8 ± 0.0 22 ± 0 -57.4
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 8 2zbg Oryctolagus cuniculus 1 10 30.0 ± 1.7 21 ± 0 -66.5
1.1.09.01. Calcium ATPase, E1P-ADP state 2zbd Oryctolagus cuniculus 1 10 31.8 ± 1.4 22 ± 2 -70.6
1.1.09.01. Calcium ATPase, E1-2Ca state, conformation 2 3ba6 Oryctolagus cuniculus 1 10 29.8 ± 0.7 19 ± 0 -59.4
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 1 2agv Oryctolagus cuniculus 1 10 29.7 ± 2.2 20 ± 2 -61.5
1.1.09.01. Calcium ATPase, E1 Ca2+ state, complex with sarcolipin 4h1w Oryctolagus cuniculus 2 11 27.6 ± 1.0 27 ± 1 -67.6
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 2 3ar8 Oryctolagus cuniculus 1 10 28.6 ± 1.8 19 ± 0 -60.6
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 6 2zbe Oryctolagus cuniculus 1 10 28.0 ± 0.7 16 ± 0 -55.4
1.1.09.01. Calcium ATPase, E1-ATP state 1t5s Oryctolagus cuniculus 1 10 29.7 ± 1.6 22 ± 1 -58.6
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 7 3n5k Oryctolagus cuniculus 1 10 28.4 ± 1.3 22 ± 2 -64.8
1.1.09.01. Calcium ATPase, E1 Mg2+ state, complex with sarcolipin 3w5a Oryctolagus cuniculus 2 11 26.8 ± 0.7 30 ± 0 -67.4
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 5 1kju Oryctolagus cuniculus 1 10 33.8 ± 0.2 26 ± 1 -68.6
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 1 1wpg Oryctolagus cuniculus 1 10 30.6 ± 1.1 20 ± 0 -70.4
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 6 1xp5 Oryctolagus cuniculus 1 10 27.4 ± 1.1 25 ± 0 -58.5
1.1.09.01. Calcium ATPase, E2 state, Ca-free, conformation 7 3ar9 Oryctolagus cuniculus 1 10 29.0 ± 0.9 20 ± 0 -73.8
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 4 3fps Oryctolagus cuniculus 1 10 30.0 ± 0.9 16 ± 0 -53.5
1.1.09.01. Calcium ATPase, E1-2Ca state, conformation 1 3ar2 Oryctolagus cuniculus 1 10 29.6 ± 0.9 25 ± 0 -70.9
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 5 3fpb Oryctolagus cuniculus 1 10 27.0 ± 2.3 23 ± 0 -64.9
1.1.09.01. Calcium ATPase, E1-2Ca state, conformation 4 2c9m Oryctolagus cuniculus 1 10 29.8 ± 1.2 27 ± 1 -54.3
1.1.11.01. Protein translocase Sec61, complex with ribosome 2wwb Canis lupus familiaris 3 12 26.3 ± 0.5 13 ± 0 -60.5
1.1.56.01. Steryl-sulfatase 1p49 Homo sapiens 1 2 29.6 ± 1.1 23 ± 0 -34.6
1.1.61.01. Microsomal glutathione S-transferase 1 2h8a Rattus norvegicus 3 12 29.7 ± 0.7 0 ± 1 -47.7
1.1.61.01. Microsomal prostaglandin E synthase 1 3dww Homo sapiens 3 12 31.9 ± 1.1 2 ± 1 -97.3
1.1.61.01. FLAP protein (5-lipoxygenase activator) 2q7r Homo sapiens 3 12 30.3 ± 1.3 0 ± 1 -70.8
1.1.61.01. Leukotriene C4 synthase 2uuh Homo sapiens 3 12 29.4 ± 1.1 0 ± 0 -55.2
1.1.70.01. CAAX prenyl protease 1 homolog 4aw6 Homo sapiens 1 7 30.8 ± 1.3 13 ± 1 -75.9
1.1.70.01. CaaX Protease Ste24p 4il3 Saccharomyces mikatae 1 7 29.8 ± 1.4 8 ± 0 -63.3
1.1.78.01. Reticulon-4 2ko2 Mus musculus 1 0 2.5 ± 0.3 83 ± 1 -6.2
1.2.07.01. Protein spitz 3ca7 Drosophila melanogaster 1 0 3.3 ± 2.8 87 ± 3 -4.3
1.2.15.02. Signal recognition particle receptor 1nrj Saccharomyces cerevisiae 2 0 3.9 ± 1.4 82 ± 11 -5.5
1.2.22.01. Fatty acid amide hydrolase 1mt5 Rattus norvegicus 2 0 11.1 ± 0.2 89 ± 0 -21.9
1.2.25.01. Phospholamban, monomer 2kb7 Homo sapiens 1 1 32.0 ± 2.2 15 ± 2 -34.6
1.2.25.01. Sarcolipin 1jdm Homo sapiens 1 1 29.6 ± 2.4 3 ± 7 -28.5
1.2.25.01. Phospholamban, cytoplasmic helix 1plp Homo sapiens 1 0 4.0 ± 1.3 80 ± 4 -7.2
1.2.25.01. Phospholamban 1zll Homo sapiens 5 5 30.5 ± 1.4 0 ± 2 -76.0
1.2.25.01. Phospholamban 1n7l Oryctolagus cuniculus 1 1 29.8 ± 3.6 34 ± 12 -32.3
1.2.25.01. Phosholamban 1fjk Sus scrofa 1 1 30.1 ± 3.2 38 ± 6 -28.3
1.2.25.02. Na,K-ATPase regulatory protein FXYD1 (phospholemman) 2jo1 Homo sapiens 1 1 30.6 ± 2.5 11 ± 4 -27.8
1.2.25.02. Na,K-ATPase regulatory protein FXYD1 (phospholemman) 2jp3 Rattus norvegicus 1 1 31.8 ± 3.2 18 ± 7 -20.2
1.2.32.01. Cytochrome P450 2B4, open state 2 1po5 Oryctolagus cuniculus 1 0 3.5 ± 1.4 79 ± 9 -7.2
1.2.32.01. Cytochrome P450 2C9 1og5 Homo sapiens 1 0 7.6 ± 1.0 79 ± 6 -13.7
1.2.32.01. Cytochrome P450 2E1 3e6i Homo sapiens 1 0 8.3 ± 2.0 49 ± 8 -14.2
1.2.32.01. Cytochrome P450 2C5, different conformation 1dt6 Oryctolagus cuniculus 1 0 7.3 ± 1.0 13 ± 7 -8.8
1.2.32.01. Cytochrome P450 19A1 (aromatase, estrogen synthetase) 3eqm Homo sapiens 1 0 6.1 ± 1.2 58 ± 8 -12.4
1.2.32.01. Cholesterol 7-alpha-monooxygenase (P450 7A1) 3dax Homo sapiens 1 0 1.8 ± 1.9 69 ± 8 -3.9
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3l4d Leishmania infantum 1 0 8.4 ± 1.8 66 ± 9 -12.6
1.2.32.01. Cytochrome P450 2C8 1pq2 Homo sapiens 1 0 3.8 ± 1.8 65 ± 9 -8.6
1.2.32.01. Cholesterol 7-alpha-monooxygenase (P450 7A1), different conformation 3sn5 Homo sapiens 1 0 6.0 ± 1.9 73 ± 4 -6.5
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 2 2wx2 Trypanosoma cruzi 1 0 5.9 ± 5.9 63 ± 2 -6.2
1.2.32.01. Cytochrome P450 2C9, different conformation 1r9o Homo sapiens 1 0 4.0 ± 1.1 59 ± 8 -10.1
1.2.32.01. Cytochrome P450 2B6 3ibd Homo sapiens 1 0 4.7 ± 1.0 57 ± 3 -10.8
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 1 2wuz Trypanosoma cruzi 1 0 4.0 ± 1.1 75 ± 11 -9.9
1.2.32.01. Steroid 21-hydroxylase (P450 C21) 3qz1 Bos taurus 1 0 5.9 ± 1.6 72 ± 3 -10.4
1.2.32.01. Cytochrome P450 2B4, closed state 3 3g5n Oryctolagus cuniculus 1 0 5.7 ± 1.8 65 ± 3 -12.1
1.2.32.01. Cytochrome P450 2B4, closed state 1 1suo Oryctolagus cuniculus 1 0 4.6 ± 1.3 57 ± 4 -14.2
1.2.32.01. Prostacyclin synthase (cytochrome P450 8A1) 3b6h Homo sapiens 1 0 5.0 ± 1.6 64 ± 18 -6.3
1.2.32.01. Cytochrome P450 3A4, conformation 2 3nxu Homo sapiens 1 0 9.3 ± 1.0 52 ± 12 -17.5
1.2.32.01. Cytochrome P450 2B4, open state 1 2bdm Oryctolagus cuniculus 1 0 10.6 ± 1.0 48 ± 15 -16.2
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3g1q Trypanosoma brucei 1 0 8.1 ± 1.5 62 ± 12 -10.8
1.2.32.01. Cytochrome P450 2B4, open state 3 3r1b Oryctolagus cuniculus 1 0 5.7 ± 0.0 43 ± 5 -9.8
1.2.32.01. Cytochrome P450 2B4, closed state 2 2q6n Oryctolagus cuniculus 1 0 5.5 ± 0.4 55 ± 2 -13.0
1.2.32.01. Cytochrome P450 2C5 1nr6 Oryctolagus cuniculus 1 0 10.6 ± 1.0 54 ± 18 -9.1
1.2.32.01. Cytochrome P450 1A2 2hi4 Homo sapiens 1 0 6.9 ± 1.0 66 ± 9 -16.2
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 2 3mdm Homo sapiens 1 0 3.8 ± 1.3 51 ± 8 -5.9
1.2.32.01. Cytochrome P450 2D6, conformation 3 3qm4 Homo sapiens 1 0 9.0 ± 1.4 35 ± 11 -9.3
1.2.32.01. Cytochrome P450 2A6 1z10 Homo sapiens 1 0 5.0 ± 1.7 44 ± 18 -9.5
1.2.32.01. Cytochrome P450 2D6, conformation 1 2f9q Homo sapiens 1 0 7.0 ± 1.8 29 ± 10 -12.0
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 1 2q9f Homo sapiens 1 0 2.8 ± 1.0 86 ± 7 -5.8
1.2.32.01. Cytochrome P450 2B6, different conformation 3ua5 Homo sapiens 1 0 4.7 ± 1.1 55 ± 3 -12.9
1.2.32.01. Cytochrome P450 2A13 2p85 Homo sapiens 1 0 4.9 ± 0.4 47 ± 2 -10.0
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 3 3ksw Trypanosoma cruzi 1 0 8.0 ± 6.7 61 ± 6 -9.1
1.2.32.01. Cytochrome P450 3A4, conformation 1 1tqn Homo sapiens 1 0 8.7 ± 1.0 67 ± 11 -18.5
1.2.32.01. Cytochrome P450 2R1 3czh Homo sapiens 1 0 8.3 ± 1.5 48 ± 13 -13.2
1.2.32.01. Steroid 17-alpha-hydroxylase/17,20 lyase (P450 17A1) 3swz Homo sapiens 1 0 4.2 ± 1.6 56 ± 3 -8.4
1.2.32.01. Cytochrome P450 2D6, conformation 2 3tda Homo sapiens 1 0 8.0 ± 0.7 35 ± 7 -12.5
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3ld6 Homo sapiens 1 0 8.9 ± 0.6 57 ± 2 -16.8
1.2.32.01. Cytochrome P450 1B1 3pm0 Homo sapiens 1 0 3.8 ± 0.7 79 ± 1 -7.0
1.2.32.01. Cytochrome P450 1A1 4i8v Homo sapiens 1 0 7.1 ± 1.0 64 ± 3 -15.1
1.2.34.01. Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4 (OST4) 2lat Homo sapiens 1 1 31.8 ± 3.5 23 ± 16 -21.3
1.2.34.01. Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4 (OST4) 1rkl Saccharomyces cerevisiae 1 1 24.8 ± 3.2 22 ± 8 -18.4
1.2.39.01. Endoplasmic reticulum aminopeptidase 2 3se6 Homo sapiens 1 0 2.5 ± 1.8 60 ± 21 -4.5
1.2.39.01. Endoplasmic reticulum aminopeptidase 1 3mdj Homo sapiens 1 0 1.9 ± 3.6 63 ± 10 -4.6
1.2.39.01. Endoplasmic reticulum aminopeptidase 1, different conformation 2yd0 Homo sapiens 1 0 4.1 ± 2.2 59 ± 8 -4.6
1.2.42.01. Glideosome-associated protein 50 3tgh Plasmodium falciparum 1 0 4.2 ± 3.4 69 ± 3 -4.3
2.1.04.01. Prostaglandin H2 synthase-1 1q4g Ovis aries 2 0 8.9 ± 0.4 90 ± 1 -43.4
2.1.04.01. Alpha-dioxygenase 1 4hhr Arabidopsis thaliana 1 0 10.8 ± 0.1 68 ± 2 -31.4
2.1.04.01. Prostaglandin H2 synthase-2 (cyclooxygenase) 1cx2 Mus musculus 2 0 9.7 ± 0.4 89 ± 3 -37.4
2.1.05.01. Lanosterol synthase 1w6k Homo sapiens 1 0 7.6 ± 1.0 77 ± 4 -17.8
2.1.17.01. Small hydrophilic endoplasmic reticulum-associated protein (Sherp) 2x43 Leishmania major 1 0 4.1 ± 0.3 82 ± 2 -9.0
2.1.36.01. Endoplasmic reticulum oxidoreductin, a mutant 3m31 Saccharomyces cerevisiae 1 0 1.9 ± 1.2 27 ± 9 -6.2
2.1.36.01. Endoplasmic reticulum oxidoreductin 1rp4 Saccharomyces cerevisiae 1 0 2.0 ± 1.8 16 ± 9 -4.7
2.1.59.01. Squalene synthase, conformation 1 3v66 Homo sapiens 1 0 3.1 ± 0.8 83 ± 6 -5.1
2.1.59.01. Squalene synthase, conformation 2 3vjc Homo sapiens 1 0 7.3 ± 0.9 62 ± 4 -6.9
2.2.02.02. Hepatitis C virus NS3 protease 2o8m Hepatitis C virus 4 0 5.0 ± 1.3 72 ± 8 -9.0
2.2.02.02. HCV serine protease NS3 3p8n Hepatitis C virus 2 0 8.7 ± 1.7 56 ± 8 -9.9
2.2.02.03. Serine protease/helicase NS3 2whx Dengue virus 2 0 4.4 ± 2.3 68 ± 9 -5.6
2.2.02.03. Flavivirin protease NS2B 2wv9 Murray valley encephalitis virus 1 0 1.6 ± 2.4 69 ± 8 -4.7
2.2.06.01. Prostaglandin-H2 D-isomerase 2ktd Mus musculus 1 0 0.0 ± 1.4 73 ± 14 -2.2
2.2.06.02. Prostaglandin-H2 D-isomerase 3o22 Homo sapiens 1 0 0.7 ± 1.2 78 ± 13 -2.4
2.2.54.01. Non-structural protein 5A 3fqm Hepatitis C virus 1 0 4.9 ± 1.1 77 ± 7 -7.5
2.3.04.01. Corticosteroid 11-beta-dehydrogenase, isozyme 1 3g49 Cavia porcellus 2 0 7.0 ± 0.5 90 ± 1 -15.9
2.3.04.01. Corticosteroid 11-beta-dehydrogenase, isozyme 1 1xu7 Homo sapiens 2 0 7.9 ± 0.2 89 ± 1 -20.2
2.3.04.01. Corticosteroid 11-beta-dehydrogenase, isozyme 1 1y5m Mus musculus 2 0 4.6 ± 0.4 89 ± 2 -19.3
2.3.05.05. Secretory pathway GDP dissociation inhibitor 2bcg Saccharomyces cerevisiae 2 0 3.5 ± 1.0 70 ± 6 -8.5
2.3.06.15. Polyneuridine-aldehyde esterase 2wfm Rauvolfia serpentina (Serpentwood) 1 0 2.5 ± 1.7 88 ± 3 -4.6
2.3.14.01. Phosphatidylinositol transfer protein PDR16 4fmm Saccharomyces cerevisiae 1 0 9.9 ± 2.6 78 ± 19 -13.9
2.3.16.05. ATPase Get3, complex with Get1 cytosolic domain 3sja Saccharomyces cerevisiae 4 0 6.4 ± 1.6 89 ± 45 -8.1
2.3.16.05. ATPase Get3, homodimer 3a36 Saccharomyces cerevisiae 2 0 5.6 ± 3.0 66 ± 10 -6.6
2.3.16.08. Interferon-inducible GTPase 1 1tpz Mus musculus 1 0 2.5 ± 2.0 37 ± 7 -5.0
2.4.06.01. Acyl-coenzyme A thioesterase 11 3fo5 Homo sapiens 1 0 2.3 ± 1.4 57 ± 7 -3.9
2.4.41.01. Hepatitis C virus non-structural protein NS2 2hd0 Hepatitis C virus 2 0 6.7 ± 0.6 85 ± 0 -11.8
3.1.07.05. Nonstructural protein 5a 2ajo Bovine viral diarrhea virus 1 0 5.0 ± 1.0 86 ± 15 -11.8
3.1.07.05. Nonstructural protein 4b, segment 1938-1965 of polyprotein 2kdr Hepatitis C virus 1 1 22.4 ± 2.0 48 ± 2 -19.1
3.1.07.05. Nonstructural protein 5a, segment 1973-2003 of polyprotein 1r7g Human hepatitis C virus 1 0 5.3 ± 0.9 90 ± 5 -15.1
3.1.07.05. Nonstructural protein 4b, segment 1751-1780 of polyprotein 2jxf Hepatitis C virus 1 0 5.6 ± 3.6 85 ± 2 -10.6
3.1.07.06. NS2 protease, segment 869-908 of polyprotein 2kwz Hepatitis C virus 1 1 29.8 ± 1.6 59 ± 7 -15.7
3.1.07.06. NS2 protease, segment 810-837 of polyprotein 2jy0 Hepatitis C virus 1 1 23.8 ± 2.9 14 ± 4 -11.4
3.1.07.06. NS2 protease, segment 836-868 of polyprotein 2kwt Hepatitis C virus 1 0 9.5 ± 3.6 81 ± 3 -15.7
3.1.07.08. Peptide of outer capsid glycoprotein VP7 (266-326) 2lm7 Rotavirus A 1 0 10.2 ± 1.5 76 ± 0 -13.6
3.1.09.01. ICP47 protein, active domain (1-34) 1qlo Human herpesvirus 1 0 8.6 ± 0.8 58 ± 8 -10.2