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• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

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1a25 » Protein kinase C beta

• Type: 2. Monotopic/peripheral (4 classes)
• Class: 2.2. All beta monotopic/peripheral (57 superfamilies)
• Superfamily: 2.2.11. C2 domain (1 family)
• Family: 2.2.11.01. C2 domain (34 proteins)
• Species: Rattus norvegicus (74 proteins)
• Localization: Eukaryotic plasma membrane (479 proteins)

1a25 » Protein kinase C beta
Depth	3.1 ± 1.0 Å
Tilt Angle	44 ± 18°
ΔGtransfer	-2.8 kcal/mol
Links to 1a25	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	cytoplasmic
Resolution	2.7 Å
Other PDB entries of this protein	none
Number of subunits	1

Experimental Verification for 1a25 » Protein kinase C beta
Maximal membrane binding affinity: -4.1 kcal/mol (Johnston and Cornell 1999) or -7.5 kcal/mol (Nalefski et al. 2001).

2 references
Johnson JE, Cornell RB. 1999. Amphitropic proteins: regulation by reversible membrane interactions (review). Mol Membr Biol. 16:217-35. PubMed
Nalefski EA, Wisner MA, Chen JZ, Sprang SR, Fukuda M, Mikoshiba K, Falke JJ. 2001. C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity. Biochemistry. 40:3089-100. PubMed

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA