PDB ID or protein name

1a25 » Protein kinase C beta, C2 domain

1a25 » Protein kinase C beta, C2 domain
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1a25 » Protein kinase C beta, C2 domain
Depth 3.1 ± 1.0 Å
Tilt Angle 44 ± 18°
ΔGtransfer -2.8 kcal/mol
Links to 1a25 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.7 Å
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 1a25 » Protein kinase C beta, C2 domain
Maximal membrane binding affinity: -4.1 kcal/mol (Johnston and Cornell 1999) or -7.5 kcal/mol (Nalefski et al. 2001).
2 references
Johnson JE, Cornell RB. 1999. Amphitropic proteins: regulation by reversible membrane interactions (review). Mol Membr Biol. 16:217-35. PubMed
Nalefski EA, Wisner MA, Chen JZ, Sprang SR, Fukuda M, Mikoshiba K, Falke JJ. 2001. C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity. Biochemistry. 40:3089-100. PubMed