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1aj1 » Actagardine, structure in acetonitrile solution

• Type: 3. Peptides (4 classes)
• Class: 3.4. Peptides of nonregular structure (9 superfamilies)
• Superfamily: 3.4.02. Lantibiotic peptides (class I bacteriocins) (6 families) 1.C.20 (TCDB)
• Family: 3.4.02.01. Actagardine (1 protein)
• Species: Actinoplanes liguriae (1 protein)
• Localization: Secreted (681 proteins)

1aj1 » Actagardine, structure in acetonitrile solution
Hydrophobic Thickness or Depth	3.0 ± 1.1 Å
Tilt Angle	90 ± 11°
ΔGtransfer	-5.7 kcal/mol
Links to 1aj1	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	out
Resolution	NMR
Other PDB entries of this protein	none
Number of subunits	1

1 reference
Zimmermann N, Jung G. 1997. The three-dimensional solution structure of the lantibiotic murein-biosynthesis-inhibitor actagardine determined by NMR. Eur J Biochem. 246: 809-819. PubMed

Comments on 1aj1 » Actagardine, structure in acetonitrile solution
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. The 14-19 beta-methyllanthionine thioether bond is oxidized to a sulfoxide. This is followed by membrane translocation and cleavage of the modified precursor.

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University of Michigan, Ann Arbor, MI 48109 USA