PDB ID or protein name

1aj1 » Actagardine, structure in acetonitrile solution

1aj1 » Actagardine, structure in acetonitrile solution
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1aj1 » Actagardine, structure in acetonitrile solution
Hydrophobic Thickness or Depth 3.0 ± 1.1 Å
Tilt Angle 90 ± 11°
ΔGtransfer -5.7 kcal/mol
Links to 1aj1 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries representing this structure none
Number of subunits 1
1 reference
Zimmermann N, Jung G. 1997. The three-dimensional solution structure of the lantibiotic murein-biosynthesis-inhibitor actagardine determined by NMR. Eur J Biochem. 246: 809-819. PubMed
Comments on 1aj1 » Actagardine, structure in acetonitrile solution
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. The 14-19 beta-methyllanthionine thioether bond is oxidized to a sulfoxide. This is followed by membrane translocation and cleavage of the modified precursor.