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• Protein Classification

• Types (3 types)
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1b12 » Type 1 signal peptidase, complex with inhibitor

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.63. Peptidase SF (1 family)
• Family: 1.1.63.01. Peptidase S26 (4 proteins)
• Species: Escherichia coli (178 proteins)
• Localization: Bacterial Gram-negative inner membrane (269 proteins)

1b12 » Type 1 signal peptidase, complex with inhibitor
Hydrophobic Thickness	5.4 ± 1.8 Å
Tilt Angle	88 ± 7°
ΔGtransfer	-5.1 kcal/mol
Links to 1b12	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	out
Resolution	1.9 Å
Other PDB entries of this protein	none
Number of TM subunits	1

Experimental Verification for 1b12 » Type 1 signal peptidase, complex with inhibitor
This is a two-pass TM protein (UniProt). See comments for 1kn9.

1 reference
Paetzel M, Dalbey RE, Strynadka NC. 1998. Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor. Nature. 396:186-90. PubMed

Comments on 1b12 » Type 1 signal peptidase, complex with inhibitor
Consistent with membrane binding mode proposed by Paetzel et al. (1998).

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA