PDB ID or protein name

1c4e » Gurmarin

1c4e » Gurmarin
Magnify 1c4e » GurmarinEnlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Secreted
Topologyout side
in side
1c4e » Gurmarin
Depth 3.9 ± 2.6 Å
Tilt Angle 75 ± 16°
ΔGtransfer -4.8 kcal/mol
Links to 1c4e PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries representing this structure 1gur
Number of subunits 1
Experimental Verification for 1c4e » Gurmarin
No experimental data about interactions with lipid bilayers.
1 reference
Ota M, Shimizu Y, Tonosaki K, Ariyoshi Y. 1998. Role of hydrophobic amino acids in gurmarin, a sweetness-suppressing polypeptide. Biopolymers. 45: 231-238. PubMed
Comments on 1c4e » Gurmarin
Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. Tyr-13, Tyr-14, Trp-28, and Trp-29 are probably involved in interactions with receptor (Ota et al. 1998). Other sweetness-inhibiting substances (gymnemic acid, ziziphin); sweet proteins (monellin, thaumatin and mabinlin); and taste-modifying proteins (miraculin and curculin) were studied. Structures of monellin and thaumatin are in the PDB.