PDB ID or protein name

1cjy » Cytosolic phospholipase A2, group IVA

1cjy » Cytosolic phospholipase A2, group IVA
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Topology in Vesicle membrane
Topologylumenal side
cytoplasmic side
1cjy » Cytosolic phospholipase A2, group IVA
Depth 5.8 ± 1.0 Å
Tilt Angle 70 ± 9°
ΔGtransfer -9.9 kcal/mol
Links to 1cjy PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.5 Å
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 1cjy » Cytosolic phospholipase A2, group IVA
Mutations of residues I399, L400 and L552 slightly affect membrane binding (Das and Cho 2002). However, these residues are completely buried in the protein interior. This is probably an indirect effect (authors suggest conformational changes). Maximal membrane binding afinity: -11 kcal/mol (Stahelin and Cho 2001).
2 references
Das S, Cho W. 2002. Roles of catalytic domain residues in interfacial binding and activation of group IV cytosolic phospholipase A2. J Biol Chem. 277:23838-46. PubMed
Stahelin RV, Cho W. 2001. Roles of calcium ions in the membrane binding of C2 domains. Biochem J. 359:679-85. PubMed
Comments on 1cjy » Cytosolic phospholipase A2, group IVA
Orientation of an isolated C2 domain (1rlw) is nearly the same.