PDB ID or protein name

1czs » C2 domain of coagulation factor V

1czs » C2 domain of coagulation factor V
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1czs » C2 domain of coagulation factor V
Depth 3.4 ± 1.6 Å
Tilt Angle 13 ± 15°
ΔGtransfer -6.2 kcal/mol
Links to 1czs PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology extracellular
Resolution 1.90 Å
Other PDB entries representing this structure 1czt, 1czv
Number of subunits 1
Experimental Verification for 1czs » C2 domain of coagulation factor V
W26, W27, L79, and S80 penetrate the bilayer core in the calculated orientation. W26 and W27 are important for membrane binding according to mutagenesis studies (Kim et al. 2000). Residues are numbered as in PDB file.
2 references
Kim SW, Quinn-Allen MA, Camp JT, Macedo-Ribeiro S, Fuentes-Prior P, Bode W, Kane WH. 2000. Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesis. Biochemistry. 39:1951-8. PubMed
Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P. Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature. 1999 Nov 25;402(6760):434-9. PubMed