PDB ID or protein name

1d7p » C2 domain of coagulation factor VIII

1d7p » C2 domain of coagulation factor VIII
Magnify 1d7p » C2 domain of coagulation factor VIIIEnlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1d7p » C2 domain of coagulation factor VIII
Depth 4.8 ± 2.0 Å
Tilt Angle 28 ± 10°
ΔGtransfer -8.8 kcal/mol
Links to 1d7p PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology extracellular
Resolution 1.5 Å
Other PDB entries representing this structure 1iqd, 3hnb, 3hny, 3hob, 4ki5, 4xzu
Number of subunits 1
Experimental Verification for 1d7p » C2 domain of coagulation factor VIII
Residues M2199, F2200, L2251 and L2252 are involved in hydrophobic interactions with the membrane (Gilbert et al. 2002) in agreement with the set of calculated membrane core embedded residues M2199, F2200, L2251 and L2252. Maximal membrane binding affinity is -11.2 kcal/mol (Gilbert et al. 2002).
1 reference
Gilbert, G.E., Kaufman, R.J., Arena, A.A., Miao, H., and Pipe, S.W. 2002. Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs. J. Biol. Chem. 277:6374-6381. PubMed
Comments on 1d7p » C2 domain of coagulation factor VIII
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. C2 domain is responsible for phospholipid-binding.