- Protein Classification
- Protein Links
 | extracellular side |
| cytoplasmic side |
| 1dan » Coagulation factor VIIa | |
|---|---|
| Depth | 4.2 ± 6.0 Å |
| Tilt Angle | 25 ± 26° |
| ΔGtransfer | -4.9 kcal/mol |
| Links to 1dan | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | extracellular |
| Resolution | 2.0 Å |
| Other PDB entries of this protein | 1fak, 1o5d, 1w0y, 1w2k, 1wqv, 1wss, 1wtg, 1wun, 1wv7, 1z6j, 2a2q, 2aei, 2aer, 2b7d, 2b8o, 2c4f, 2ec9, 2f9b, 2fir, 2flb, 2flr, 2zp0, 2zwl, 2zzu, 3ela |
| Number of subunits | 4 |
| Experimental Verification for 1dan » Coagulation factor VIIa |
|---|
| The elongated complex must be approximately perpendicular to the membrane based on a fluorescence study by McCallum et al. (1996). |
| 2 references |
|---|
| Zwaal RF, Comfurius P, Bevers EM. 1998. Lipid-protein interactions in blood coagulation. Biochim Biophys Acta. 1376:433-453. PubMed |
| McCallum CD, Hapak RC, Neuenschwander PF, Morrissey JH, Johnson AE. 1996. The location of the active site of blood coagulation factor VIIa above the membrane surface and its reorientation upon association with tissue factor. A fluorescence energy transfer study. J Biol Chem. 271:28168-75. PubMed |
| Comments on 1dan » Coagulation factor VIIa |
|---|
| Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. |
