PDB ID or protein name

1dm5 » Annexin XII

1dm5 » Annexin XII
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1dm5 » Annexin XII
Depth 2.7 ± 1.0 Å
Tilt Angle 90 ± 7°
ΔGtransfer -10.2 kcal/mol
Links to 1dm5 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.9 Å
Other PDB entries representing this structure 1aei
Number of subunits 3
Experimental Verification for 1dm5 » Annexin XII
Residues E142, S144 and G145 of annexin B12 are positioned just beyond the calculated hydrophobic boundary (subunit C of the trimer) and their side-chains are directed toward the membrane, which is consistent with spin-labeling studies (Isas et al. 2004).
1 reference
Isas, J.M., Langen, R., Hubbell, W.L., and Haigler, H.T. 2004. Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12. J. Biol. Chem. 279:32492-32498. PubMed
Comments on 1dm5 » Annexin XII
This protein undergoes major conformational changes upon association with membranes.