PDB ID or protein name

1faq » RAF-1 proto-oncogene serine/threonine-protein kinase

1faq » RAF-1 proto-oncogene serine/threonine-protein kinase
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1faq » RAF-1 proto-oncogene serine/threonine-protein kinase
Depth 4.8 ± 1.1 Å
Tilt Angle 30 ± 14°
ΔGtransfer -7.3 kcal/mol
Links to 1faq PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution NMR
Other PDB entries representing this structure 1far
Number of subunits 1
Experimental Verification for 1faq » RAF-1 proto-oncogene serine/threonine-protein kinase
Membrane-binding affinity: -5.5 kcal/mol (from Kd in Table 1, Johnson and Cornell, 1999).
1 reference
Johnson JE, Cornell RB. 1999. Amphitropic proteins: regulation by reversible membrane interactions (review). Mol Membr Biol. 16:217-35. PubMed
Comments on 1faq » RAF-1 proto-oncogene serine/threonine-protein kinase
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. This protein also includes Ras-binding domain (RBD, residues 51-132) that interacts with G-protein Rap1A (PDB entries 1c1y, 1gua, and 1rfa).