PDB ID or protein name

1fle » Elafin, complex with elastase from Pig

1fle » Elafin, complex with elastase from Pig
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Topology in Secreted
Topologyout side
in side
1fle » Elafin, complex with elastase from Pig
Depth 4.4 ± 2.0 Å
Tilt Angle 52 ± 11°
ΔGtransfer -6.3 kcal/mol
Links to 1fle PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.9 Å
Other PDB entries representing this structure 2rel
Number of subunits 2
Experimental Verification for 1fle » Elafin, complex with elastase from Pig
No direct experimental data. The calculated orientation is in agreement with probable formation of membrane-anchoring helix by N-terminal segment of elafin, which is missing in this crystal structure (Efremov et al. 2001).
1 reference
Efremov RG, Volynsky PE, Dauchez MAM, Nolde DE, Arseniev AS, Alix AJP. 2001. Assessment of conformation and energetics of the N-terminal part of elafin via computer simulations. Theor. Chem. Acc. 106: 55-61.
Comments on 1fle » Elafin, complex with elastase from Pig
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.