PDB ID or protein name

1g5m » Apoptosis regulator Bcl-2

1g5m » Apoptosis regulator Bcl-2
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Topology in Mitochondrial outer membrane
Topologyintermembrane space side
cytoplasmic side
1g5m » Apoptosis regulator Bcl-2
Hydrophobic Thickness 4.2 ± 1.4 Å
Tilt Angle 33 ± 11°
ΔGtransfer -6.6 kcal/mol
Links to 1g5m PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution NMR
Other PDB entries representing this structure 1gjh, 1ysw
Number of TM subunits 1
Experimental Verification for 1g5m » Apoptosis regulator Bcl-2
This structure includes residues 3-207. Missing C-terminal segment includes potential TM helix 212-233. The protein undergoes major conformational changes upon association with membranes.
Comments on 1g5m » Apoptosis regulator Bcl-2
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif (residues 10-30), has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity. Structure without BH4 motif is 1ysw (residues 45-207). 1gjh is a different isoform.