PDB ID or protein name

1gmi » Protein kinase C epsilon

1gmi » Protein kinase C epsilon
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1gmi » Protein kinase C epsilon
Depth 2.9 ± 1.2 Å
Tilt Angle 46 ± 15°
ΔGtransfer -5.9 kcal/mol
Links to 1gmi PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.7 Å
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 1gmi » Protein kinase C epsilon
Residue I89 and partially V29 and P31 penetrate the bilayer core. According to muatgenesis studies, the most important residue for membrane binding is I89 (Corbalan-Garcia et al. 2003). The binding is also affected by replacing Y91 and in the triple mutant W23A/R26A/R32A. These residues are in the membrane interfacial region in the calculated orientation.
1 reference
Corbalan-Garcia S, Sanchez-Carrillo S, Garcia-Garcia J, Gomez-Fernandez JC. 2003. Characterization of the membrane binding mode of the C2 domain of PKC epsilon. Biochemistry. 42:11661-8. PubMed