PDB ID or protein name

1gwy » Sticholysin II

1gwy » Sticholysin II
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Topology in Secreted
Topologyout side
in side
1gwy » Sticholysin II
Hydrophobic Thickness 3.4 ± 1.9 Å
Tilt Angle 35 ± 15°
ΔGtransfer -5.0 kcal/mol
Links to 1gwy PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.7 Å
Other PDB entries representing this structure 1o71, 1o72, 2l2b, 2l38
Number of TM subunits 1
Experimental Verification for 1gwy » Sticholysin II
St I and St II bind to biological and model membranes containing sphingomyelin, forming oligomeric pores that lead to leakage of internal contents (Alvarez et al. 2003)
1 reference
Alvarez C, Casallanovo F, Shida CS, Nogueira LV, Martinez D, Tejuca M, Pazos IF, Lanio ME, Menestrina G, Lissi E, Schreier S. 2003. Binding of sea anemone pore-forming toxins sticholysins I and II to interfaces. Chem Phys Lipids. 122:97-105. PubMed
Comments on 1gwy » Sticholysin II
This protein undergoes major conformational transitions and oligomerization upon association with membranes.