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• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

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1gwy » Sticholysin II

• Type: 2. Monotopic/peripheral (4 classes)
• Class: 2.2. All beta monotopic/peripheral (57 superfamilies)
• Superfamily: 2.2.32. Anemone pore-forming cytolysin (1 family) 1.C.38 (TCDB)
• Family: 2.2.32.01. Anemone pore-forming cytolysin (5 proteins) 1.C.38 (TCDB)
• Species: Stoichactis helianthus (4 proteins)
• Localization: Secreted (681 proteins)

1gwy » Sticholysin II
Depth	3.4 ± 1.9 Å
Tilt Angle	35 ± 15°
ΔGtransfer	-5.0 kcal/mol
Links to 1gwy	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	out
Resolution	1.7 Å
Other PDB entries of this protein	1o71, 1o72, 2l2b, 2l38
Number of subunits	1

Experimental Verification for 1gwy » Sticholysin II
St I and St II bind to biological and model membranes containing sphingomyelin, forming oligomeric pores that lead to leakage of internal contents (Alvarez et al. 2003)

1 reference
Alvarez C, Casallanovo F, Shida CS, Nogueira LV, Martinez D, Tejuca M, Pazos IF, Lanio ME, Menestrina G, Lissi E, Schreier S. 2003. Binding of sea anemone pore-forming toxins sticholysins I and II to interfaces. Chem Phys Lipids. 122:97-105. PubMed

Comments on 1gwy » Sticholysin II
This protein undergoes major conformational transitions and oligomerization upon association with membranes.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA