- Protein Classification
- Protein Links
| 1h0j » Cardiotoxin III (cytotoxin 3) | |
|---|---|
| Depth | 7.1 ± 0.9 Å |
| Tilt Angle | 59 ± 7° |
| ΔGtransfer | -11.3 kcal/mol |
| Links to 1h0j | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | out |
| Resolution | 1.9 Å |
| Other PDB entries of this protein | 1i02, 1xt3, 2bhi, 2crs, 2crt |
| Number of subunits | 1 |
| Experimental Verification for 1h0j » Cardiotoxin III (cytotoxin 3) |
|---|
| The protein was crystallized with detergent. It binds to membrane in a tilted orientation, in agreement with FTIR data for lipid monolayers (Huang et al. 2003). Also consistent with results of simulations (Efremov et al. 2004). |
| 2 references |
|---|
| Efremov RG, Nolde DE, Konshina AG, Syrtcev NP, Arseniev AS. 2004. Peptides and proteins in membranes: what can we learn via computer simulations? Curr Med Chem. 11: 2421-2442. PubMed |
| Huang, W.N., Sue, S.C., Wang, D.S., Wu, P.L., and Wu, W.G. 2003. Peripheral binding mode and penetration depth of cobra cardiotoxin on phospholipid membranes as studied by a combined FTIR and computer simulation approach. Biochemistry. 42:7457-7466. PubMed |
| Comments on 1h0j » Cardiotoxin III (cytotoxin 3) |
|---|
| Shows cytolytic activity (By similarity), and inhibits protein kinases C. Can cause leakage in vesicles. |
