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• Protein Classification

• Types (3 types)
• Classes (11 classes)
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1h2s » Sensory rhodopsin II, tetramer

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.01. Rhodopsin-like receptors and pumps (4 families) 3.E.1 (TCDB)
• Family: 1.1.01.01. Microbial and algal rhodopsins (20 proteins) 3.E.1 (TCDB)
• Species: Natronomonas pharaonis (3 proteins)
• Localization: Archaebacterial membrane (56 proteins)

1h2s » Sensory rhodopsin II, tetramer
Hydrophobic Thickness	30.5 ± 1.1 Å
Tilt Angle	0 ± 0°
ΔGtransfer	-123.4 kcal/mol
Links to 1h2s	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus extracellular)
Resolution	1.93 Å
Other PDB entries representing this structure	2f93, 2f95, 4gyc
Number of TM Secondary Structures	18

4 transmembrane subunits
A - Tilt: 8° - Segments: 1(3-24), 2(38-57), 3(70-87), 4(98-117), 5(122-141), 6(163-180), 7(190-211)
B - Tilt: 3° - Segments: 1(24-41), 2(60-81)
C - Tilt: 3° - Segments: 1(24-41), 2(60-81)
D - Tilt: 8° - Segments: 1(3-24), 2(38-57), 3(70-87), 4(98-117), 5(122-141), 6(163-180), 7(190-211)

Experimental Verification for 1h2s » Sensory rhodopsin II, tetramer
Accessibilities of eight residues to paramagnetic quenchers (Wegener et al. 2000) are consistent with locations of the calculated membrane boundaries.

1 reference
Wegener AA, Chizhov I, Engelhard M, and Steinhoff HJ (2000) Time-resolved detection of transient movement of helix F in spin-labelled pharaonis sensory rhodopsin II. J. Mol. Biol. 301: 881-891. PubMed

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA