PDB ID or protein name

1h6i » Aquaporin-1, structure 1

1h6i » Aquaporin-1, structure 1
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1h6i » Aquaporin-1, structure 1
Hydrophobic Thickness 30.8 ± 1.1 Å
Tilt Angle 0 ± 0°
ΔGtransfer -135.6 kcal/mol
Links to 1h6i PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus cytoplasmic)
Resolution 3.54 Å
Other PDB entries representing this structure 1fqy, 1ih5
Number of TM Secondary Structures 32
4 transmembrane subunits
A - Tilt: 8° - Segments: 1(11-32), 2(50-68), 3(77-87), 4(92-113), 5(135-156), 6(168-186), 7(193-202), 8(210-231)
B - Tilt: 8° - Segments: 1(11-32), 2(50-68), 3(77-87), 4(92-113), 5(135-156), 6(168-186), 7(193-202), 8(210-231)
C - Tilt: 8° - Segments: 1(11-32), 2(50-68), 3(77-87), 4(92-113), 5(135-156), 6(168-186), 7(193-202), 8(210-231)
D - Tilt: 8° - Segments: 1(11-32), 2(50-68), 3(77-87), 4(92-113), 5(135-156), 6(168-186), 7(193-202), 8(210-231)
Comments on 1h6i » Aquaporin-1, structure 1
Hydrophobic thickness is underestimated, perhaps due to a relatively poor quality of this EM-based structure. Some loops are turned "inside out", as can see from comparison with the higher resolution structure of bovine homologue (1j4n).