PDB ID or protein name

1h8p » Collagen-binding type II domain of seminal plasma protein PDC-109

1h8p » Collagen-binding type II domain of seminal plasma protein PDC-109
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1h8p » Collagen-binding type II domain of seminal plasma protein PDC-109
Depth 10.5 ± 0.9 Å
Tilt Angle 87 ± 7°
ΔGtransfer -16.6 kcal/mol
Links to 1h8p PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.8 Å
Other PDB entries representing this structure 1pdc
Number of subunits 2
Experimental Verification for 1h8p » Collagen-binding type II domain of seminal plasma protein PDC-109
Penetrates up to the level of C-14 into the hydrophobic interior of the membrane (Ramakrishnan et al. 2001). Membrane binding can be modulated by cholesterol ( Swamy et al. 2002). Consistent with orientation proposed by Wah et al. (2002).
3 references
Ramakrishnan, M., Anbazhagan, V., Pratap, T.V., and Marsh, D., Swamy MJ. 2001. Membrane insertion and lipid-protein interactions of bovine seminal plasma protein PDC-109 investigated by spin-label electron spin resonance spectroscopy. Biophys. J. 81:2215- PubMed
Swamy MJ, Marsh D, Anbazhagan V, Ramakrishnan M. 2002. Effect of cholesterol on the interaction of seminal plasma protein, PDC-109 with phosphatidylcholine membranes. FEBS Lett. 528: 230-234. PubMed
Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ. 2002. Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex. Structure. 10: 505-514. PubMed
Comments on 1h8p » Collagen-binding type II domain of seminal plasma protein PDC-109
Major component of seminal plasma. Could enhance the fertilizing capacity of bull spermatozoa upon interaction with heparin-like glycosaminoglycans present in the female genital tract. Exhibits both simulatory and inhibitory actions on the release of pituitary gonadotropins. The dimer has translational rather than C2 symmetry.