PDB ID or protein name

1hh4 » Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2

1hh4 » Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1hh4 » Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2
Depth 4.0 ± 0.6 Å
Tilt Angle 88 ± 6°
ΔGtransfer -7.2 kcal/mol
Links to 1hh4 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.7 Å
Other PDB entries of this protein 1fso, 1fst, 1ft0, 1ft3, 1kmt, 1qvy, 1rho, 2bxw
Number of subunits 2
Experimental Verification for 1hh4 » Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2
The inhibitor is bound to RAC2 protein (Ras-related C3 botulinum toxin substrate 2). RAC2 has S-geranylgeranyl cysteine 189. The geranylgeranyl residue can be buried in the membrane if the C-terminus of RAC2 is extended or unfolded (the C-terminal residues are missing in the crystal structure). The interaction with membrane is weak, since this is the inactive (GDP-bound) state. RAC2 is membrane-associated when activated.
Comments on 1hh4 » Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.