PDB ID or protein name

1hrk » Ferrochelatase, conformation 1

1hrk » Ferrochelatase, conformation 1
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Topology in Mitochondrial inner membrane
Topologyintermembrane space side
matrix space side
1hrk » Ferrochelatase, conformation 1
Depth 2.7 ± 0.1 Å
Tilt Angle 90 ± 0°
ΔGtransfer -9.9 kcal/mol
Links to 1hrk PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology matrix space
Resolution 2.0 Å
Other PDB entries representing this structure 2hrc, 2hre, 2pnj, 2po5, 2po7, 2qd1, 2qd3, 2qd4, 3aqi, 3hcp, 3w1w, 4f4d, 4kla, 4klc, 4kmm, 4mk4
Number of subunits 2
Experimental Verification for 1hrk » Ferrochelatase, conformation 1
Membrane-associated protein. Crystallization with detergent (SODIUM CHOLATE). Results are consitent with orientation proposed by Wu et al. (2001).
1 reference
Wu CK, Dailey HA, Rose JP, Burden A, Sellers VM, Wang BC. 2001. The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis. Nat Struct Biol. 8:156-60. PubMed
Comments on 1hrk » Ferrochelatase, conformation 1
Catalyzes the ferrous insertion into protoporphyrin IX: protoporphyrin + Fe(2+) = protoheme + 2 H(+).