PDB ID or protein name

1lqv » Coagulation factor XIV (protein C) in complex with its receptor

1lqv » Coagulation factor XIV (protein C) in complex with its receptor
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1lqv » Coagulation factor XIV (protein C) in complex with its receptor
Depth 3.4 ± 3.9 Å
Tilt Angle 53 ± 14°
ΔGtransfer -5.6 kcal/mol
Links to 1lqv PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology extracellular
Resolution 1.6 Å
Other PDB entries of this protein 3jtc
Number of subunits 2
Experimental Verification for 1lqv » Coagulation factor XIV (protein C) in complex with its receptor
The receptor is located above the membrane surface (Yegneswaran et al. 1997); it presumably has a TM helix 211-231.
2 references
Zwaal RF, Comfurius P, Bevers EM. 1998. Lipid-protein interactions in blood coagulation. Biochim Biophys Acta. 1376:433-453. PubMed
Yegneswaran, S., Wood, G.M., Esmon, C.T., and Johnson, A.E. 1997. Protein S alters the active site location of activated protein C above the membrane surface. A fluorescence resonance energy transfer study of topography. J. Biol. Chem. 272:25013-25021. PubMed
Comments on 1lqv » Coagulation factor XIV (protein C) in complex with its receptor
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.