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• Protein Classification

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1mii » alpha-conotoxin MII

• Type: 3. Peptides (4 classes)
• Class: 3.1. Alpha-helical peptides (32 superfamilies)
• Superfamily: 3.1.20. Alpha-conotoxins (1 family)
• Family: 3.1.20.01. Alpha-conotoxin (18 proteins)
• Species: Conus magus (2 proteins)
• Localization: Secreted (681 proteins)

1mii » alpha-conotoxin MII
Hydrophobic Thickness or Depth	2.7 ± 1.8 Å
Tilt Angle	45 ± 19°
ΔGtransfer	-4.2 kcal/mol
Links to 1mii	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	out
Resolution	NMR
Other PDB entries of this protein	1m2c, 2ajw, 2ak0
Number of subunits	1

Experimental Verification for 1mii » alpha-conotoxin MII
Detected membrane-binding site interacts with acetylcholine receptor. See structures of the complexes (2br8 and 2c9t).

Comments on 1mii » alpha-conotoxin MII
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. In contrast to other alpha-conotoxins, this peptide has no detectable activity at the muscle subtype of receptor, but instead, it potently targets neuronal nAChR.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA