PDB ID or protein name

1mii » alpha-conotoxin MII

1mii » alpha-conotoxin MII
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Topology in Secreted
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1mii » alpha-conotoxin MII
Hydrophobic Thickness or Depth 2.7 ± 1.8 Å
Tilt Angle 45 ± 19°
ΔGtransfer -4.2 kcal/mol
Links to 1mii PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries representing this structure 1m2c, 2ajw, 2ak0
Number of subunits 1
Experimental Verification for 1mii » alpha-conotoxin MII
Detected membrane-binding site interacts with acetylcholine receptor. See structures of the complexes (2br8 and 2c9t).
Comments on 1mii » alpha-conotoxin MII
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. In contrast to other alpha-conotoxins, this peptide has no detectable activity at the muscle subtype of receptor, but instead, it potently targets neuronal nAChR.