• HOME
• ABOUT OPM
• DOWNLOAD OPM FILES
• CONTACT US
• PPM SERVER
• LIPID COMPOSITION ATLAS

• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

• Protein Links

• PDB Sum,
• PDB,
• OCA,
• MPKS,
• PDBTM,
• MPDB,
• CGDB

1nr6 » Cytochrome P450 2C5

• Type: 1. Transmembrane (3 classes)
• Class: 1.2. Alpha-helical bitopic (42 superfamilies)
• Superfamily: 1.2.32. Cytochrome P450 (1 family)
• Family: 1.2.32.01. Cytochrome P450 (49 proteins)
• Species: Oryctolagus cuniculus (37 proteins)
• Localization: Endoplasmic reticulum membrane (125 proteins)

1nr6 » Cytochrome P450 2C5
Hydrophobic Thickness	10.6 ± 1.0 Å
Tilt Angle	54 ± 18°
ΔGtransfer	-9.1 kcal/mol
Links to 1nr6	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	cytoplasmic
Resolution	2.1 Å
Other PDB entries of this protein	1n6b
Number of TM subunits	1

Experimental Verification for 1nr6 » Cytochrome P450 2C5
Crystallization with detergent (CYMAL-5). This cytochrome has a tentative N-terminal TMH, consistent with the calculated orientation.

Comments on 1nr6 » Cytochrome P450 2C5

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA