PDB ID or protein name

1nr6 » Cytochrome P450 2C5

1nr6 » Cytochrome P450 2C5
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1nr6 » Cytochrome P450 2C5
Hydrophobic Thickness 10.6 ± 1.0 Å
Tilt Angle 54 ± 18°
ΔGtransfer -9.1 kcal/mol
Links to 1nr6 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.1 Å
Other PDB entries representing this structure 1n6b
Number of TM subunits 1
Experimental Verification for 1nr6 » Cytochrome P450 2C5
Crystallization with detergent (CYMAL-5). This cytochrome has a tentative N-terminal TMH, consistent with the calculated orientation.
Comments on 1nr6 » Cytochrome P450 2C5
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.