PDB ID or protein name

1nu2 » Disabled homolog 1

1nu2 » Disabled homolog 1
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1nu2 » Disabled homolog 1
Depth 14.8 ± 1.1 Å
Tilt Angle 46 ± 12°
ΔGtransfer -17.6 kcal/mol
Links to 1nu2 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.9 Å
Other PDB entries representing this structure 1ntv, 1oqn
Number of subunits 1
Experimental Verification for 1nu2 » Disabled homolog 1
This position was calculated for the complex with bound lipid. Lipid acyl chains were modelled. Calculated hydrocarbon boundary of the lipid bilayer corresponds to the carbonyl groups of the bound lipid. Transfer energy was calculated without contribution from the bound lipid(orientation of the protein without bound lipid is different). Membrane penetration depth of the protein is poorly defined because it strongly depends on the bound lipid conformation (the protein can move away of the hydrophobic boundary).
Comments on 1nu2 » Disabled homolog 1
Adapter molecule functioning in neural development. Associates with the SH2 domains of Src, Fyn and Abl. Interacts with SIAH1.