PDB ID or protein name

1nzn » Mitochondria fission 1 protein, crystal structure

1nzn » Mitochondria fission 1 protein, crystal structure
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Topology in Mitochondrial outer membrane
Topologyintermembrane space side
cytoplasmic side
1nzn » Mitochondria fission 1 protein, crystal structure
Hydrophobic Thickness 6.1 ± 1.4 Å
Tilt Angle 72 ± 8°
ΔGtransfer -9.3 kcal/mol
Links to 1nzn PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.0 Å
Other PDB entries representing this structure none
Number of TM subunits 1
Experimental Verification for 1nzn » Mitochondria fission 1 protein, crystal structure
Additional membrane-anchoring elements: C-terminal segment 123-147 (missing in the crystal structure) presumably forms a TM helix, which is geometrically possible in this membrane-association mode. The C-terminal TM helix was unfolded in aqueous solution, even in the presence of bicelles (Suzuki et al. 2003)
2 references
Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M. 2005. A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell. 16: 5077-86. PubMed
Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N. 2003. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J Mol Biol. 334: 445-458. PubMed
Comments on 1nzn » Mitochondria fission 1 protein, crystal structure
Function - see Koch et al. (2005).