PDB ID or protein name

1o5w » Monoamine oxidase A

1o5w » Monoamine oxidase A
Magnify 1o5w » Monoamine oxidase AEnlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Mitochondrial outer membrane
Topologyintermembrane space side
cytoplasmic side
1o5w » Monoamine oxidase A
Hydrophobic Thickness 31.4 ± 3.4 Å
Tilt Angle 20 ± 3°
ΔGtransfer -23.1 kcal/mol
Links to 1o5w PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus cytoplasmic)
Resolution 3.2 Å
Other PDB entries representing this structure none
Number of TM Secondary Structures 1
1 transmembrane subunit
A - Tilt: 20° - Segments: 1(501-518)
Experimental Verification for 1o5w » Monoamine oxidase A
Membrane binding mode is similar to that proposed by Ma et al. (2004). Crystallization with detergent (DIMETHYLDECYLPHOSPHINE OXIDE/FOSCHOLINE-12).
1 reference
Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T. 2004. Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors. J Mol Biol. 338: 103-114. PubMed
Comments on 1o5w » Monoamine oxidase A
Monomer, homo- or heterodimer. Enzymatically active as monomer. Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAO-A preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.