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• Protein Classification

• Types (3 types)
• Classes (11 classes)
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1o5w » Monoamine oxidase A

• Type: 1. Transmembrane (3 classes)
• Class: 1.2. Alpha-helical bitopic (42 superfamilies)
• Superfamily: 1.2.33. Transmembrane proteins with NAD(P)-binding Rossmann-fold domains (2 families)
• Family: 1.2.33.02. Flavin containing amine oxidoreductase (8 proteins)
• Species: Rattus norvegicus (74 proteins)
• Localization: Mitochondrial outer membrane (20 proteins)

1o5w » Monoamine oxidase A
Hydrophobic Thickness	31.4 ± 3.4 Å
Tilt Angle	20 ± 3°
ΔGtransfer	-23.1 kcal/mol
Links to 1o5w	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus cytoplasmic)
Resolution	3.2 Å
Other PDB entries of this protein	none
Number of TM Secondary Structures	2

Experimental Verification for 1o5w » Monoamine oxidase A
Membrane binding mode is similar to that proposed by Ma et al. (2004). Crystallization with detergent (DIMETHYLDECYLPHOSPHINE OXIDE/FOSCHOLINE-12).

1 reference
Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T. 2004. Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors. J Mol Biol. 338: 103-114. PubMed

Comments on 1o5w » Monoamine oxidase A
Monomer, homo- or heterodimer. Enzymatically active as monomer. Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAO-A preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA