PDB ID or protein name

1ocu » PX domain of sorting nexin GRD19, ligand-bound

1ocu » PX domain of sorting nexin GRD19, ligand-bound
Magnify 1ocu » PX domain of sorting nexin GRD19, ligand-boundEnlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Endosome membrane
Topologylumenal side
cytoplasmic side
1ocu » PX domain of sorting nexin GRD19, ligand-bound
Depth 15.3 ± 0.8 Å
Tilt Angle 88 ± 6°
ΔGtransfer -34.9 kcal/mol
Links to 1ocu PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.3 Å
Other PDB entries representing this structure none
Number of subunits 2
Experimental Verification for 1ocu » PX domain of sorting nexin GRD19, ligand-bound
This position was calculated for the complex with bound lipid. Lipid acyl chains were modelled. Calculated hydrocarbon boundary of the lipid bilayer corresponds to the carbonyl groups of the bound lipid. Spatial positions of the protein calculated with and without the bound lipid are almost identical. Transfer energy was calculated without contribution from the bound lipid.
1 reference
Cho W, Stahelin RV. 2005. Membrane-protein interactions in cell signaling and membrane trafficking. Annu Rev Biophys Biomol Struct. 34:119-51. PubMed
Comments on 1ocu » PX domain of sorting nexin GRD19, ligand-bound
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Subcellular localization of PX domains - see Cho and Stahelin (2005).