PDB ID or protein name

1og5 » Cytochrome P450 2C9, structure 1

1og5 » Cytochrome P450 2C9, structure 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1og5 » Cytochrome P450 2C9, structure 1
Hydrophobic Thickness 7.6 ± 1.0 Å
Tilt Angle 79 ± 6°
ΔGtransfer -13.7 kcal/mol
Links to 1og5 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.5 Å
Other PDB entries representing this structure 1og2, 4nz2
Number of TM subunits 1
Experimental Verification for 1og5 » Cytochrome P450 2C9, structure 1
Crystallization with detergent (CYMAL-5). This cytochrome has a tentative N-terminal TMH, consistent with the calculated orientation.
Comments on 1og5 » Cytochrome P450 2C9, structure 1
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.