PDB ID or protein name

1okh » Viscotoxin A3

1okh » Viscotoxin A3
Magnify 1okh » Viscotoxin A3Enlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Secreted
Topologyout side
in side
1okh » Viscotoxin A3
Depth 4.6 ± 1.3 Å
Tilt Angle 32 ± 19°
ΔGtransfer -4.9 kcal/mol
Links to 1okh PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.7 Å
Other PDB entries representing this structure 1ed0
Number of subunits 1
Experimental Verification for 1okh » Viscotoxin A3
Interacts with lipid bilayers (see the references). It possibly forms ion channels (Giudici et al. 2006).
4 references
Coulon A, Berkane E, Sautereau AM, Urech K, Rouge P, Lopez A. 2002. Modes of membrane interaction of a natural cysteine-rich peptide: viscotoxin A3. Biochim Biophys Acta. 1559: 145-159. PubMed
Coulon A, Mosbah A, Lopez A, Sautereau AM, Schaller G, Urech K, Rouge P, Darbon H. 2003. Comparative membrane interaction study of viscotoxins A3, A2 and B from mistletoe (Viscum album) and connections with their structures. Biochem J. 374: 71-8. PubMed
Giudici M, Pascual R, de la Canal L, Pfuller K, Pfuller U, Villalain J. 2003. Interaction of viscotoxins A3 and B with membrane model systems: implications to their mechanism of action. Biophys J. 85: 971-81. PubMed
Giudici M, Poveda JA, Molina ML, de la Canal L, Gonzalez-Ros JM, Pfuller K, Pfuller U, Villalain J. 2006. Antifungal effects and mechanism of action of viscotoxin A3. FEBS J. 273: 72-83. PubMed