PDB ID or protein name

1pen » alpha-conotoxin PNI1

1pen » alpha-conotoxin PNI1
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Topology in Secreted
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1pen » alpha-conotoxin PNI1
Hydrophobic Thickness or Depth 5.2 ± 1.7 Å
Tilt Angle 27 ± 19°
ΔGtransfer -3.8 kcal/mol
Links to 1pen PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.1 Å
Other PDB entries representing this structure 2br8
Number of subunits 1
Experimental Verification for 1pen » alpha-conotoxin PNI1
Detected membrane-interaction site is also involved in protein-protein binding: see complex with acetylcholine receptor, 2br8 (A10L substitution in conotoxin).
Comments on 1pen » alpha-conotoxin PNI1
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.